Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)

Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)

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Networked: 864 relevant articles (11 outcomes, 101 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gerardy-Schahn, Rita: 14 articles (01/2015 - 08/2003)
2.	Schachner, Melitta: 12 articles (01/2014 - 10/2002)
3.	Mühlenhoff, Martina: 9 articles (10/2013 - 08/2004)
4.	Berezin, Vladimir: 9 articles (12/2012 - 01/2002)
5.	Maness, Patricia F: 8 articles (01/2014 - 05/2003)
6.	Kaur, Gurcharan: 8 articles (01/2014 - 05/2003)
7.	Bock, Elisabeth: 8 articles (12/2012 - 01/2002)
8.	Hildebrandt, Herbert: 7 articles (01/2015 - 08/2003)
9.	Horstkorte, Rüdiger: 7 articles (08/2012 - 03/2004)
10.	Terada, Tadashi: 6 articles (10/2014 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1998 - "This study was undertaken to evaluate polysialylated NCAM as a marker helpful in distinguishing between various embryonal tumors and other lesions suspicious of a malignancy. " 01/01/2011 - "In this tissue microarray-based immunohistochemical study, we confirmed the expression of NCAM in Wilms tumors, nephrogenic rests, and metanephric mesenchyme and its early derivatives in fetal renal cortex. " 11/01/2005 - "In the present study, we have aimed to clarify the hypothesis that NCAM-mediated inhibition of salivary gland tumor proliferation is caused by homophilic binding and involves the prevention of signal transduction for perineural invasion using HSG cells. " 05/01/2003 - "Furthermore, in such very few previous studies on NCAM expression in MCC, all the tumor cells were not necessarily demonstrated to express NCAM. " 05/15/1998 - "To the authors' knowledge, this study provides the first direct evidence that NCAM is down-regulated in the development of the malignancy of astrocytic tumors; and it is suggested that reduced NCAM expression might be involved in the development of biologic malignancy."
2.	Neoplasm Metastasis (Metastasis) 10/01/2013 - "Importantly, significant changes were demonstrated in the protein expression level of three metastatic-associated genes (NCAM, FOXG1, and ITGA4), and knockdown of one of the identified HOPX-regulated metastatic genes, ITGA4, showed marked inhibition of cell motility and metastasis formation. " 10/01/2012 - "Treatment with low-dose ZOL can reduce NCAM expression that may contribute toward reduced spinal cord metastasis, suggesting that NCAM is an alternative therapeutic target and that the low-dose ZOL treatment protocol is a reasonable approach for its treatment." 10/01/2012 - "Low-dose ZOL significantly reduced spinal cord metastasis probably through reduced NCAM expression in vivo. " 10/01/2011 - "Soluble NCAM status was a significant independent factor predictive of long-term survival in patients with HCC, and high levels of soluble NCAM were significantly related to intrahepatic metastasis. " 04/01/2010 - "This cells line, pretreated with an anti-NCAM antibody and inoculated intravenously (i.v.) into syngeneic mice, developed less and smaller lung metastases. "
3.	Schizophrenia (Dementia Praecox) 07/30/2010 - "In schizophrenia, a significant reduction in the ratio of the two major membrane-bound forms of NCAM (180 and 140) was observed in BA10. " 01/01/1997 - "To investigate the possible involvement of the NCAM gene in schizophrenia, we conducted a comprehensive genetic study, which included linkage analysis and an association study employing the Haplotype Relative Risk (HRR) design in nuclear families. " 01/01/1997 - "NCAM and schizophrenia: genetic studies." 01/01/2015 - "Post-mortem and genetic evidence suggests that dysregulation of polySia-NCAM is involved in schizophrenia (SZ). " 01/01/2015 - "A growing body of evidence links aberrant levels of NCAM and polySia as well as variation in the ST8SIA2 gene to neuropsychiatric disorders, including schizophrenia. "
4.	Brain Injuries (Brain Injury) 05/30/2008 - "The synthetic NCAM-derived peptide, FGL, modulates the transcriptional response to traumatic brain injury." 06/01/2008 - "The NCAM-derived P2 peptide facilitates recovery of cognitive and motor function and ameliorates neuropathology following traumatic brain injury." 07/01/2012 - "To study the effects of astragalan (AG) on the expression of the neural cell adhesion molecule(NCAM) and c-fos of hippocampus CA1 region after the ischemic brain injury in rats. " 04/01/1997 - "Previously, we have evaluated changes in the rate of synaptic remodeling in brain injury by calculating the ratio of the neural cell adhesion molecule (NCAM) to D3(SNAP-25). " 08/28/2000 - "The regional expression of proteins associated with axonal elongation, such as microtubule-associated protein 1B (MAP1B), its phosphorylated isoform (MAP1B-P), growth-associated protein 43 (GAP-43), and polysialylated neural cell-adhesion molecule (PSA-NCAM), was examined using immunohistochemistry from 24 hours to 2 months following lateral fluid percussion brain injury of moderate severity (2.4-2.6 atmospheres) in anesthetized rats. "
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2001 - "In this study we confirm the observation of some authors that NCAM expression occurs in some cases of non-small-cell lung carcinomas." 11/01/1998 - "Neural cell adhesion molecule expression: prognosis in 889 patients with resected non-small cell lung cancer." 06/01/1996 - "We investigated the clinical significance of expression of this NCAM isoform as a prognostic factor in a series of 96 non-small cell lung carcinomas resected with curative intent. " 10/01/1993 - "We therefore concluded that NCAM expression in non-small-cell lung cancer is correlated to nodal status and that it indicates a poor prognosis. " 10/01/1993 - "Patients with NCAM-positive non-small-cell lung cancer proved to have a shorter survival than those with NCAM-negative disease. "

Related Drugs and Biologics

1.	Synaptophysin
2.	Chromogranin A
3.	Kainic Acid (Kainate)
4.	Liposomes (Liposome)
5.	Doxorubicin (Adriamycin)
6.	P2 peptide
7.	Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)
8.	polysialic acid
9.	polysialyl neural cell adhesion molecule
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intraperitoneal Injections
3.	Heterologous Transplantation (Xenotransplantation)
4.	Immunotherapy
5.	Denervation