Galanin

A neuropeptide of 29-30 amino acids depending on the species. Galanin is widely distributed throughout the BRAIN; SPINAL CORD; and INTESTINES. There are various subtypes of GALANIN RECEPTORS implicating roles of galanin in regulating FOOD INTAKE; pain perception; memory; and other neuroendocrine functions.

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Networked: 715 relevant articles (14 outcomes, 101 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hökfelt, Tomas: 24 articles (07/2015 - 04/2002)
2.	Wynick, David: 17 articles (06/2015 - 11/2002)
3.	Shi, Mingyi: 14 articles (12/2015 - 08/2011)
4.	Zhang, Zhenwen: 13 articles (12/2015 - 08/2012)
5.	Fang, Penghua: 13 articles (12/2015 - 08/2011)
6.	Bo, Ping: 13 articles (12/2015 - 08/2012)
7.	Kofler, Barbara: 13 articles (01/2015 - 02/2002)
8.	Hökfelt, T: 13 articles (06/2008 - 06/2000)
9.	El-Salhy, Magdy: 10 articles (08/2005 - 01/2002)
10.	Holmes, Fiona E: 9 articles (06/2015 - 11/2002)

Related Diseases

1.	Seizures (Seizure) 04/17/2009 - "The results suggest that the protective effects of exercise against seizures are at least partially mediated by regulation of neural excitability through a process involving galanin." 01/01/2014 - "Our study shows that galanin-releasing ECB devices moderately suppress focal stimulation-induced recurrent seizures. " 04/01/2009 - "Thus, these studies clearly demonstrate the anti-seizure effectiveness of AAV vector-mediated expression and constitutive secretion of galanin." 06/01/2015 - "Given the availability of galanin agonists which inhibit seizures, our findings could potentially have direct implications for the development of anti-epileptic treatment. " 01/01/2015 - "Our previous efforts focused on improving blood-brain-barrier penetration and enhancing the metabolic stability of galanin analogs to protect against seizures. "
2.	Alzheimer Disease (Alzheimer's Disease) 09/01/2010 - "Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats." 04/01/1994 - "These studies reveal increased concentrations of galanin in the cerebral cortex of Alzheimer's disease, similar to previous findings in basal forebrain tissue. " 01/01/1989 - "In the present study for the first time galanin immunoreactivity in the human Ch2 region is morphologically investigated and related to the severity of hippocampal plaques and neurofibrillary tangles in Alzheimer's disease. " 12/01/1988 - "In the present study, galanin-like immunoreactivity was measured in the postmortem cerebral cortex and hippocampus of 10 controls and 14 patients who had had Alzheimer's disease. " 09/01/2010 - "It is recently reported that galanin plays a role in memory decline that is the primary behavioral symptom of Alzheimer's disease. "
3.	Neuralgia (Stump Neuralgia) 12/21/1998 - "Thus, stable galanin agonists may be useful in the treatment of inflammatory and neuropathic pain." 10/01/2015 - "Also, the effect of M617 was attenuated by M35, a GalR1/2 antagonist; at the same time, M35 reduced the galanin-induced antinociception, suggesting that GalR1 mediates antinociception induced by galanin in the NAc of rats with neuropathic pain. " 01/01/2012 - "Effects of exogenous galanin on neuropathic pain state and change of galanin and its receptors in DRG and SDH after sciatic nerve-pinch injury in rat." 01/01/2009 - "These results suggest that galanin and NPY play a role in modulating neuropathic pain in the gracile nucleus of the medulla." 01/01/2009 - "High doses of galanin inhibited neuropathic pain behaviors. "
4.	Hyperalgesia 02/01/1999 - "GMAP relieved mechanical allodynia much less than galanin. " 01/01/2015 - "Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways." 01/01/2014 - "A role of supraspinal galanin in behavioural hyperalgesia in the rat." 01/01/2010 - "Phenotypic analysis revealed markedly attenuated allodynia when galanin is overexpressed and an increase in allodynia following galanin suppression. " 06/01/2005 - "In apparent contradiction to these findings, galanin KO animals fail to develop allodynia and hyperalgesia after nerve injury. "
5.	Body Weight (Weight, Body) 08/01/2013 - "In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. " 08/01/2010 - "Our studies demonstrate that alarin, like other members of the galanin family, is a neuromediator of food intake and body weight." 11/01/2002 - "The aim of this study was to determine the effect of GALP on feeding, body weight and core body temperature after central administration in rats compared to the effects of galanin. " 08/01/2013 - "From these results we concluded that selection for body weight likely did not affect galanin function on induction of feeding in either lines, and that the effect of galanin is associated with arcuate nucleus activation in chicks. " 08/01/2013 - "Stimulation of food intake after central galanin is associated with arcuate nucleus activation and does not differ between genetically selected low and high body weight lines of chickens."

Related Drugs and Biologics

1.	Neuropeptide Y
2.	Neuropeptides
3.	Substance P
4.	Calcitonin Gene-Related Peptide
5.	Acetylcholine (Acetylcholine Chloride)
6.	Adrenocorticotropic Hormone (ACTH)
7.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
8.	Norepinephrine (Noradrenaline)
9.	Kainic Acid (Kainate)
10.	galantide (M 15)

Related Therapies and Procedures

1.	Denervation
2.	Axotomy
3.	Subcutaneous Injections
4.	Ligation
5.	Rhizotomy