Galanin

A neuropeptide of 29-30 amino acids depending on the species. Galanin is widely distributed throughout the BRAIN; SPINAL CORD; and INTESTINES. There are various subtypes of GALANIN RECEPTORS implicating roles of galanin in regulating FOOD INTAKE; pain perception; memory; and other neuroendocrine functions.

Also Known As:

Networked: 931 relevant articles (23 outcomes, 159 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fang, Penghua: 31 articles (05/2022 - 06/2011)
2.	Zhang, Zhenwen: 29 articles (05/2022 - 08/2012)
3.	Shi, Mingyi: 29 articles (01/2020 - 12/2009)
4.	Hökfelt, Tomas: 28 articles (02/2020 - 04/2002)
5.	Bo, Ping: 25 articles (01/2020 - 08/2012)
6.	Wynick, David: 21 articles (06/2015 - 09/2001)
7.	Kofler, Barbara: 20 articles (12/2021 - 02/2002)
8.	Yu, Mei: 16 articles (12/2020 - 12/2011)
9.	Zhu, Yan: 14 articles (01/2019 - 09/2012)
10.	Hökfelt, T: 13 articles (06/2008 - 06/2000)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 12/21/1998 - "Thus, stable galanin agonists may be useful in the treatment of inflammatory and neuropathic pain." 02/05/2021 - "This study focused on the involvement of GalR2 in galanin-induced antinociceptive effect in NAc of neuropathic pain rats. " 01/01/2019 - "The present study aimed to explore the antinociceptive effect induced by galanin in rats with neuropathic pain and the underlying mechanism. " 09/01/2016 - "Various studies have reported that galanin can promote axonal regeneration of dorsal root ganglion neurons in vitro and inhibit neuropathic pain. " 12/01/2020 - "Beneficial effects of galanin system on diabetic peripheral neuropathic pain and its complications."
2.	Insulin Resistance 12/01/2015 - "Studies also implicated that combination of aerobic exercise and activation of galanin system may make more significant improvement in insulin sensitivity than that of either one did. " 06/01/2022 - "This study laid the foundation for exploring the relationship between galanin and insulin sensitivity." 01/01/2016 - "Our previous studies testified the beneficial effect of central galanin on insulin sensitivity of type 2 diabetic rats. " 12/01/2014 - "Our previous studies had found that galanin might facilitate insulin sensitivity via activation of its central receptors. " 12/01/2013 - "This review provides a comprehensive aggregation of the current literature available, bringing together data gleaned from our recent studies highlighting the role of galanin in regulating insulin sensitivity. "
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2021 - "However, recent studies have confirmed that the number of galanin-immunoreactive INH neurons is larger in men than women and decreases with age and have reported further loss with Alzheimer disease. " 09/01/2010 - "Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats." 04/01/1994 - "These studies reveal increased concentrations of galanin in the cerebral cortex of Alzheimer's disease, similar to previous findings in basal forebrain tissue. " 01/01/1989 - "In the present study for the first time galanin immunoreactivity in the human Ch2 region is morphologically investigated and related to the severity of hippocampal plaques and neurofibrillary tangles in Alzheimer's disease. " 12/01/1988 - "In the present study, galanin-like immunoreactivity was measured in the postmortem cerebral cortex and hippocampus of 10 controls and 14 patients who had had Alzheimer's disease. "
4.	Hyperalgesia 02/01/1999 - "GMAP relieved mechanical allodynia much less than galanin. " 01/01/2017 - "In the chronic phase, injured rats showed well-established mechanical and cold allodynia and significant increases in galanin, NPY, GalR1 and Y1R mRNAs, while maintaining reduced GalR2 expression. " 01/01/2015 - "Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways." 01/01/2014 - "A role of supraspinal galanin in behavioural hyperalgesia in the rat." 10/21/2010 - "Phenotypic analysis revealed markedly attenuated allodynia when galanin is overexpressed and an increase in allodynia following galanin suppression. "
5.	Stomach Neoplasms (Stomach Cancer) 03/01/2019 - "Galanin expression is down-regulated in patients with gastric cancer." 01/01/2018 - "Here, we describe the epigenetic silencing of galanin in human gastric cancer. " 01/01/2018 - "However, the exact role of galanin in gastric cancer is unclear. " 01/01/2018 - "Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells." 06/15/1994 - "Prolonged administration of galanin at 4 micrograms/kg body weight, but not at 2 micrograms/kg body weight, significantly decreased the incidence of gastric cancers in experimental week 52. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Neuropeptides
3.	Substance P
4.	Neuropeptide Y
5.	Calcitonin Gene-Related Peptide
6.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
7.	Acetylcholine (Acetylcholine Chloride)
8.	Adrenocorticotropic Hormone (ACTH)
9.	Norepinephrine (Noradrenaline)
10.	Kainic Acid (Kainate)

Related Therapies and Procedures

1.	Denervation
2.	Therapeutics
3.	Axotomy
4.	Ligation
5.	Subcutaneous Injections