Phosphotyrosine

An amino acid that occurs in endogenous proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis.

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Networked: 354 relevant articles (5 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Moran, Michael F: 4 articles (01/2015 - 11/2009)
2.	McMurray, John S: 3 articles (11/2015 - 01/2012)
3.	Pandey, Akhilesh: 3 articles (10/2015 - 01/2015)
4.	Taylor, Paul: 3 articles (01/2015 - 11/2009)
5.	Morlacchi, Pietro: 2 articles (11/2015 - 01/2014)
6.	Mandal, Pijus K: 2 articles (11/2015 - 01/2012)
7.	Way, Michael: 2 articles (11/2015 - 06/2013)
8.	Zhang, Zhen: 2 articles (10/2015 - 07/2015)
9.	Barbhuiya, Mustafa A: 2 articles (10/2015 - 01/2015)
10.	Renuse, Santosh: 2 articles (10/2015 - 01/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2001 - "At the same time, a highly significant reduction in the number of the phosphotyrosine-positive tumor cells was observed (40.9% from 64.9%; P < 0.0001). " 09/01/2013 - "In this study, a prodrug delivery strategy was used to introduce an enzymatically stable, phosphotyrosine peptidomimetic into tumor cells. " 02/15/2014 - "We present here the first report of PID1 (Phosphotyrosine Interaction Domain containing 1; NYGGF4) in cancer. " 12/01/2013 - "Phosphoproteomics in particular has allowed for the efficient surveying of phosphotyrosine signaling pathways involved in various diseases states, most prominently in cancer. " 10/08/2013 - "Phosphotyrosine phosphorylation is a key protein modification driving cellular response also involved in disease/cancer molecular pathways."
2.	Insulin Resistance 07/01/2013 - "NYGGF4, also known as phosphotyrosine interaction domain containing 1(PID1), is a recently discovered gene which is involved in obesity-related insulin resistance (IR) and mitochondrial dysfunction. " 02/15/2013 - "Phosphotyrosine interaction domain containing 1 (PID1) is an important mediator in the development of obesity-related insulin resistance in humans and animals. " 07/27/2012 - "Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes." 09/01/2008 - "Our results confirm the role of Galpha(i2) in development of insulin resistance by crosstalk between the reduced level of inhibitory G-protein and insulin receptor mediated most likely by activation of phosphotyrosine protein dephosphorylation." 11/01/2004 - "Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance."
3.	Leukemia 01/01/2009 - "Flow cytometric analysis of phosphotyrosine levels is a reliable and convenient adjuvant technique for diagnosis of Bcr-Abl-positive leukemias and shows promise for serial evaluation of patients undergoing treatment." 08/01/1988 - "The cellular phosphotyrosine content of the HL-60 promyelocytic leukemia markedly decreased during the induced granulocytic and monocytic maturation of these cells. " 01/01/1988 - "Finally, similar alterations in phosphotyrosine regulation were exhibited during anthracycline-induced differentiation of the murine myelomonocytic leukemia cell line WEHI-3B D+, supporting the concept that the phenomena measured represent a general response to inducers of the granulocytic differentiation of leukemia cells." 10/15/1986 - "About 1.5% of phosphorylated amino acid residues of HL-60 promyelocytic leukemia cells are phosphotyrosine. " 07/01/1985 - "Peripheral blood cells and bone marrow cells from patients with various types of leukemia, but not those from healthy persons, were brightly immunofluorescent (IF) after staining with monoclonal antibody reactive to O-phosphotyrosine. "
4.	Tics (Tic) 03/01/2008 - "Here, we show a label-free method for relative quantification based on the TIC from peptide MS/MS spectra collected from data-dependent runs can be used effectively as a quantitative measure and expands the dynamic range over isotope labeling experiments allowing for abundance differences up to approximately 60:1 in a screen for proteins that bind to phosphotyrosine residues." 05/01/1992 - "When the neutrophils were treated with Triton X-100 (Sigma Chemical Co, St Louis, MO) to evaluate cytoskeletal associations of proteins, the 150 phosphotyrosine protein partitioned with the Triton X-100 insoluble cytoskeleton (TICS), and the 70-Kd protein partitioned with both the TICS and Triton X-100 soluble proteins. "
5.	Type B Niemann-Pick Disease 03/01/2013 - "Cholesterol trapping in Niemann-Pick disease type B fibroblasts can be relieved by expressing the phosphotyrosine binding domain of GULP."

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Proteins (Proteins, Gene)
3.	Glucose (Dextrose)
4.	Cholesterol
5.	Myostatin
6.	Insulin Receptor
7.	Monoclonal Antibodies
8.	Tyrosine (L-Tyrosine)
9.	Antibodies
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Ligation
2.	Castration
3.	Aftercare (After-Treatment)