Myelin P2 Protein

A positively charged protein found in peripheral nervous system MYELIN. Sensitive immunological techniques have demonstrated that P2 is expressed in small amounts of central nervous system myelin sheaths of some species. It is an antigen for experimental allergic neuritis (NEURITIS, EXPERIMENTAL ALLERGIC), the peripheral nervous system counterpart of experimental allergic encephalomyelitis. (From Siegel et al., Basic Neurochemistry, 5th ed, p133)

Also Known As:

Networked: 22 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Berciano, J: 2 articles (07/2022 - 07/2018)
2.	Gold, R: 2 articles (12/2002 - 11/2001)
3.	Bellone, Emilia: 1 article (01/2020)
4.	Fossa, Paola: 1 article (01/2020)
5.	Gemelli, Chiara: 1 article (01/2020)
6.	Geroldi, Alessandro: 1 article (01/2020)
7.	Grandis, Marina: 1 article (01/2020)
8.	Lanteri, Paola: 1 article (01/2020)
9.	Mandich, Paola: 1 article (01/2020)
10.	Origone, Paola: 1 article (01/2020)

Related Diseases

1.	Experimental Autoimmune Neuritis 06/01/1992 - "Experimental allergic neuritis is mediated by CD4+ T cells reactive with myelin P2 protein. " 12/01/1984 - "The role of myelin P2 protein in the production of experimental allergic neuritis." 07/01/2022 - "We analysed histological, electrophysiological, and imaging findings from patients with AIDP and AMAN, and compared them to those of an animal model of myelin P2 protein-induced experimental allergic neuritis. " 07/26/2018 - "We analysed histological, electrophysiological, and imaging findings from patients with AIDP and AMAN, and compared them to those of an animal model of myelin P2 protein-induced experimental allergic neuritis. " 07/05/1996 - "The conformation of SP-26, the synthetic peptide (residues 53-78) of myelin P2 protein that causes experimental autoimmune neuritis (EAN) in the peripheral nervous system, has been investigated in D2O using Fourier transform infra-red spectroscopy. "
2.	Guillain-Barre Syndrome 12/01/2002 - "AT-EAN is a model of Guillain-Barré syndrome, induced by injection of activated T lymphocytes sensitized to myelin P2 protein. " 05/01/1975 - "Cellular hypersensitivity to basic myelin (P2) protein in the Guillain-Barré syndrome."
3.	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/01/2016 - "We performed whole exome sequencing on a patient with Charcot-Marie-Tooth disease type 1 and identified a de novo mutation in PMP2, the gene that encodes the myelin P2 protein. " 01/01/2020 - "Early onset demyelinating Charcot-Marie-Tooth disease caused by a novel in-frame isoleucine deletion in peripheral myelin protein 2."
4.	Cryptococcal Meningitis 09/01/2015 - "Overexpression of major histocompatibility complexes, class I, B (HLA-B), actin alpha 2 smooth muscle aorta (ACTA2) and caveolin 1 (CAV1) and downregulation of peripheral myelin protein 2 (PMP2) and alpha crystallin B chain (CRYAB) in cryptococcal meningitis were confirmed by IHC-based validation experiments. "
5.	Spinal Cord Diseases 07/01/1977 - "Lymphocytes from patients with acute transverse myelopathy (ATM) were shown to undergo a specific and significant transformation when cultured in vitro in the presence of either the central nervous myelin basic encephalitogenic protein (BE) or the peripheral nerve myelin P2 protein. "

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