Myosin Light Chains (Myosin Essential Light Chain)

The smaller subunits of MYOSINS that bind near the head groups of MYOSIN HEAVY CHAINS. The myosin light chains have a molecular weight of about 20 KDa and there are usually one essential and one regulatory pair of light chains associated with each heavy chain. Many myosin light chains that bind calcium are considered "calmodulin-like" proteins.

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Networked: 313 relevant articles (2 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Szczesna-Cordary, Danuta: 12 articles (01/2015 - 07/2005)
2.	Li, Tao: 7 articles (04/2014 - 01/2008)
3.	Xu, Jing: 7 articles (04/2014 - 01/2008)
4.	Sawicki, Grzegorz: 7 articles (11/2013 - 07/2005)
5.	Kazmierczak, Katarzyna: 6 articles (01/2015 - 10/2010)
6.	Liu, Liangming: 6 articles (04/2014 - 01/2008)
7.	Cadete, Virgilio J J: 6 articles (11/2013 - 05/2011)
8.	Sawicka, Jolanta: 6 articles (11/2013 - 07/2005)
9.	Moore, Jeffrey R: 5 articles (12/2014 - 04/2010)
10.	Muthu, Priya: 5 articles (12/2014 - 02/2012)

Related Diseases

1.	Hypothyroidism 08/01/1992 - "In hypothyroidism, it may be related to decreased clearance of normal LCI concentration or increased myosin light chain from damaged skeletal muscle. " 03/01/1982 - "Hypothyroidism caused fast to slow changes in fiber type composition (99% decrease in proportion of type II fibers), ATPase activities (down 20-30%), myosin light chain pattern (54% less fast light chains), calcium uptake by SR (down 60%), LDH activity (down 11%), and isozyme pattern (9% decrease in M-subunits). "
2.	AIDS-Related Complex (ARC) 07/01/2008 - "Additionally, quantification of phosphorylated myosin light chain levels in ARC-treated or Y-27632-treated cells implies that ARC is more effective than Y-27632 in suppressing the phosphorylation of at least one of the substrates of ROCK. " 08/01/2014 - "Enhanced TW myosin light chain phosphorylation, arc formation, and brush border fanning coincided with intermicrovillous bacterial penetration, which were inhibited by ML-7 and neutralizing anti-IFN-γ but not Y27632. "
3.	Anoxia (Hypoxia) 07/01/2007 - "The aim of the present study was to examine the contribution of endothelial myosin light chain (MLC) phosphorylation to hypoxia-induced blood-brain barrier (BBB) opening. " 06/01/2015 - "In human PASMC, inhibition of TRPV4 blocked the hypoxia-induced Ca influx and myosin light chain phosphorylation. " 04/26/2013 - "In both normoxia and hypoxia, PASMC HIF-1α maintains low pulmonary vascular tone by decreasing myosin light chain phosphorylation. " 04/26/2013 - "Moreover, myosin light chain phosphorylation, a determinant of SMC tone, was higher in PASMCs isolated from SM22α-HIF-1α(-/-) mice compared with wild-type PASMCs, during both normoxia and after acute hypoxia. " 04/26/2013 - "Hypoxia-inducible factor-1α in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation."
4.	Neoplasms (Cancer) 07/01/2013 - "In a previous study we injected nude mice with CCL13-HBx cells and identified in contrast to non-HBx transfected cells a differentially phosphorylated myosin light chain (p-MLC) by two-dimensional PAGE and mass spectrometry of the tumor material. " 07/22/2010 - "In this study, we show that cancer cells often failed at cytokinesis because of decreased phosphorylation of the myosin regulatory light chain (MLC), a key regulatory component of cortical contraction during division. " 01/01/2013 - "Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells." 07/22/2010 - "Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells." 02/26/2010 - "Blocking myosin regulatory light chain phosphorylation with small molecule inhibitors alters the shape, adhesion, and migration of many types of smooth muscle and cancer cells. "
5.	Infection 05/01/2013 - "In this study, we focused on phosphorylation of Penaeus monodon myosin regulatory light chain (PmMRLC) that is induced at an early hour post YHV infection and is concomitant with cellular actin remodeling. " 01/01/2015 - "SeV infection increases cellular stiffness and myosin light chain phosphorylation at two hour post infection. " 05/01/2013 - "Phosphorylation is required for myosin regulatory light chain (PmMRLC) to control yellow head virus infection in shrimp hemocytes." 12/01/1997 - "Infection of epithelial cells with enteropathogenic Escherichia coli (EPEC) induces phosphorylation of the 20-kilodalton myosin light chain (MLC20). " 06/01/1996 - "Phosphorylation of myosin light chain at distinct sites and its association with the cytoskeleton during enteropathogenic Escherichia coli infection."

Related Drugs and Biologics

1.	Y 27632
2.	Protein Kinase C
3.	Myosin-Light-Chain Phosphatase
4.	rho-Associated Kinases
5.	Protein Isoforms (Isoforms)
6.	Myosin-Light-Chain Kinase
7.	Proteins (Proteins, Gene)
8.	Tropomyosin
9.	Myosin Heavy Chains (Myosin Heavy Chain)
10.	myosin-binding protein C

Related Therapies and Procedures

1.	Vertical Dimension (Occlusion Vertical Dimension)
2.	Positive-Pressure Respiration (PEEP)
3.	Ligation
4.	Intraperitoneal Injections
5.	Injections