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Myelin-Associated Glycoprotein (S-MAG)

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A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It has a structure that is similar to members of the Ig superfamily that participate in cell adhesion. (From Siegel et al., Basic Neurochemistry, 5th ed, p132)

Also Known As:

S-MAG; L-MAG; Large Myelin-Associated Glycoprotein Isoform; Pleural Glycoproteins; Small Myelin-Associated Glycoprotein Isoform; Glycoprotein, Myelin-Associated; Glycoproteins, Pleural; L MAG; Large Myelin Associated Glycoprotein Isoform; Myelin Associated Glycoprotein; Protein, MAG; S MAG; Small Myelin Associated Glycoprotein Isoform; MAG Protein

Networked: 307 relevant articles (7 outcomes, 34 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Steck, Andreas J: 5 articles (09/2015 - 03/2003)
2.	Kawagashira, Yuichi: 4 articles (09/2015 - 09/2010)
3.	Sobue, Gen: 4 articles (09/2015 - 09/2010)
4.	Koike, Haruki: 4 articles (09/2015 - 09/2010)
5.	Kusunoki, Susumu: 4 articles (02/2015 - 09/2010)
6.	Nobile-Orazio, E: 4 articles (02/2013 - 04/2000)
7.	Love, Seth: 3 articles (04/2015 - 07/2013)
8.	Iijima, Masahiro: 3 articles (01/2015 - 09/2010)
9.	Katsuno, Masahisa: 3 articles (01/2015 - 09/2010)
10.	Marklund, Niklas: 3 articles (01/2014 - 12/2006)

Related Diseases

1.	Polyneuropathies (Polyneuropathy) 02/01/2015 - "Anti-myelin-associated-glycoprotein (MAG) neuropathy is an intractable autoimmune polyneuropathy. " 10/01/2013 - "Anti-myelin-associated glycoprotein (MAG) neuropathy is a primary demyelinating sensorimotor polyneuropathy that can be very debilitating and is known to be resistant to treatment. " 09/01/2009 - "ELISA is more sensitive than Western blot to diagnose anti-myelin-associated glycoprotein related polyneuropathy, although a positive serology may be found in other forms of polyneuropathy as well." 02/01/2009 - "Anti-myelin-associated glycoprotein (MAG) neuropathy is an antibody-mediated polyneuropathy. " 01/01/2001 - "We describe an association of MBCL with anti-myelin-associated glycoprotein (MAG) polyneuropathy in a 53-year-old male. "
2.	Peripheral Nervous System Diseases (PNS Diseases) 03/01/2009 - "Patient A 56-year-old man with peripheral neuropathy diagnosed as anti-myelin-associated glycoprotein neuropathy. " 03/01/2003 - "We found one published case of Schnitzler's syndrome and myelin-associated glycoprotein reactive peripheral neuropathy. " 01/01/2009 - "Anti-myelin-associated glycoprotein peripheral neuropathy as the only presentation of low grade lymphoma: a case report." 01/01/2003 - "patients of any age with anti-Myelin Associated Glycoprotein antibody associated demyelinating peripheral neuropathy with monoclonal gammopathy of undetermined significance of any severity. " 03/01/1999 - "Autoimmune responses to the myelin-associated glycoprotein (MAG) are implicated in the immunopathogenesis of both multiple sclerosis (MS) and certain peripheral neuropathies. "
3.	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 04/01/2010 - "GBS, however, is still a serious disease with a mortality rate of 8% and 20% of the patients being unable to walk independently a year after onset For CIDP and related disorders such as multifocal motor neuropathy, and demyeinating neuropathy with anti-myelin-associated-glycoprotein (MAG) antibody, treatments should be based on individual pathophysiology. " 05/01/2009 - "Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN), and anti-myelin-associated glycoprotein (anti-MAG) neuropathy are three demyelinating acquired neuropathies, with distinct responses to immunotherapy. " 05/01/2012 - "The main chronic autoimmune neuropathies include chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy (MMN), and anti-myelin-associated glycoprotein (MAG) demyelinating neuropathy. " 03/01/2012 - "A demyelinating pattern was observed in 15 patients, 10 having anti-myelin-associated glycoprotein (anti-MAG) antibodies and 5 having neuropathy related to chronic inflammatory demyelinating polyradiculoneuropathy. " 06/01/2008 - "These features are useful in differential diagnosis of POEMS syndrome from chronic inflammatory demyelinating polyneuropathy (CIDP) and neuropathy associated with anti-myelin-associated glycoprotein antibody. "
4.	Inclusion Body Myositis 05/19/2004 - "In other controlled studies, IVIG produced a modest, variable, and transient but not statistically significant benefit in patients with inclusion body myositis and paraproteinemic anti-myelin-associated glycoprotein antibody demyelinating polyneuropathy. " 06/01/2004 - "In paraproteinemic IgM anti-MAG (myelin-associated glycoprotein) demyelinating polyneuropathies and inclusion body myositis (IBM), the benefit is variable, marginal, and not statistically significant. " 11/01/1999 - "The clinical efficacy of IVIg, based on controlled clinical trials conducted in patients with GBS, CIDP, multifocal motor neuropathy (MMN), DM, MG, LEMS, paraproteinemic IgM anti-myelin-associated glycoprotein (anti-MAG) demyelinating polyneuropathies, and inclusion body myositis is summarized and practical issues related to each disorder are addressed. "
5.	Brain Injuries (Brain Injury) 01/01/2014 - "Following traumatic brain injury (TBI) in the rat, pharmacological neutralisation of the MAIs Nogo-A and myelin-associated glycoprotein (MAG) resulted in improved functional outcome. " 01/01/2008 - "We have studied the effects of the fluid percussion injury (FPI) model of traumatic brain injury (TBI) on protein levels of two myelin-associated molecules, myelin-associated glycoprotein (MAG) and Nogo-A, in the adult rat. " 12/01/2006 - "Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody." 07/01/2010 - "Functional recovery is markedly restricted following traumatic brain injury (TBI), partly due to myelin-associated inhibitors including Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), that all bind to the Nogo-66 receptor-1 (NgR1). " 09/10/2003 - "Oligodendrocyte-myelin glycoprotein (OMgp) is expressed on the surface of oligodendrocytes and neurones and is thought to inhibit axonal regeneration after brain injury in adult, like Nogo and myelin-associated glycoprotein (MAG). "

Related Drugs and Biologics

1.	Immunoglobulin M (IgM)
2.	rituximab (Mabthera)
3.	Intravenous Immunoglobulins (IVIG)
4.	Antibodies
5.	sulfate-3-glucuronyl paragloboside
6.	paragloboside (neolactotetraosylceramide)
7.	Peroxidase (Myeloperoxidase)
8.	Antigens
9.	Proteins (Proteins, Gene)
10.	Paraffin

Related Therapies and Procedures

1.	Immunotherapy
2.	Plasmapheresis
3.	Immunomodulation
4.	Transplantation (Transplant Recipients)
5.	Plasma Exchange