T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)

Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.

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Networked: 1675 relevant articles (97 outcomes, 164 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sette, Alessandro: 45 articles (07/2022 - 09/2003)
2.	Sidney, John: 28 articles (07/2022 - 07/2002)
3.	Peters, Bjoern: 22 articles (07/2022 - 09/2005)
4.	De Groot, Anne S: 19 articles (11/2022 - 03/2006)
5.	Moise, Leonard: 14 articles (11/2022 - 10/2009)
6.	Martin, William D: 14 articles (01/2021 - 10/2009)
7.	Sollid, Ludvig M: 14 articles (11/2019 - 09/2002)
8.	Celis, Esteban: 13 articles (12/2021 - 10/2004)
9.	Rammensee, Hans-Georg: 12 articles (01/2022 - 02/2002)
10.	Neumann-Haefelin, Christoph: 11 articles (10/2022 - 03/2006)

Related Diseases

1.	Infections 04/24/2020 - "In addition, high levels of recall memory T cells targeted to an immunodominant H2b-restricted CD8 T-cell epitope were detected in the immunized mice after the AdV5 challenge, and the magnitude of these responses correlated with the level of protection against pulmonary pathology caused by the AdV5 infection. " 09/01/2006 - "Because the functional impact of these genes during normal infection of C57BL/6 mice is surprisingly modest, we wanted to determine whether the VIPRs are equally effective against the entire spectrum of H-2(b)-restricted CD8 T cell epitopes. " 01/01/2018 - "In this study, we developed a CD4+ T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus (LCMV) infection. " 11/15/2012 - "It has been recently reported by our group that dendrimeric constructs combining B- and T-cell epitopes from classical swine fever virus (CSFV) provided partial protection against experimental infection. " 09/01/2007 - "Identification of prominent T-cell epitopes from FhSAP-2 offers the possibility of understanding how the CD4+ T-cell response is involved in protection against fasciolosis and how it is implicated in susceptibility to infection."
2.	Neoplasms (Cancer) 10/01/2015 - "Enhanced tumor immunity was associated with improved CD8(+) T cell expansion and reduced tolerization, and it was dependent on presentation of both CD4(+) and CD8(+) T cell epitopes by the same dendritic cell population. " 01/01/2022 - "Collectively, identification of the VSV-GP T cell epitopes enables monitoring of the full range of anti-viral T cell responses upon VSV-GP virotherapy in future studies with preclinical mouse models to more comprehensively delineate anti-viral from anti-tumor T cell responses. " 06/01/2009 - "In this study, we determined whether predicted T cell epitopes from FAK would be able to induce anti-tumor immune cellular responses. " 02/01/2008 - "Since the identified T cell epitopes constitute physiological targets in the immune response to HPV16 and HPV18 positive tumors they will be valuable for detailed studies on the interactions between the tumor and the immune system. " 09/26/1997 - "This study describes a simple method for long-term establishment of human ovarian tumor lines and prediction of T-cell epitopes that could be potentially useful in the generation of tumor-specific cytotoxic T lymphocytes (CTLs). "
3.	Malaria 09/28/2012 - "cruzi, which intrinsically bears the same CD8(+) T cell epitope significantly improved the survival of ANYNFTLV-expressing malaria-infected mice but not that of control malaria-infected ones. " 09/28/2012 - "The present study generated genetically engineered murine malaria, Plasmodium yoelii, which expresses a well-defined Trypanosoma cruzi-derived, H-2K(b)-restricted CD8(+) T cell epitope, ANYNFTLV. " 01/01/2021 - "Comparative analysis of the ex vivo IFN-gamma responses to CD8+ T cell epitopes within allelic forms of PfAMA1 in subjects with natural exposure to malaria." 07/01/2020 - "Many pathogens, including malaria, have polymorphic T cell epitope regions. " 01/07/2020 - "Currently, few T cell epitopes derived from Plasmodium falciparum, the major aetiologic agent of malaria in humans are known. "
4.	Human Influenza (Influenza) 01/01/2008 - "Transgenic mice expressing wild-type CD62L cleared a recombinant vaccinia virus expressing an influenza-derived CD8 T cell epitope as efficiently as C57BL/6 mice. " 02/01/2015 - "The objective of this study was to analyse the ability of diabetic mice to mobilize innate and CD8(+) T cell-mediated immune response to influenza A virus (IAV) with the live influenza A/Puerto Rico/8/1934 H1N1 (PR8) strain or with its immunodominant CD8(+) T cell epitopes. " 01/01/2012 - "In this study, we used this method to uncover several cross-specific MHC class I specific T cell epitopes naturally presented by influenza A-infected cells. " 01/01/2019 - "Class II-restricted T cell epitopes that were highly conserved across influenza subtypes were identified. " 01/01/2019 - "Highly conserved influenza T cell epitopes induce broadly protective immunity."
5.	Hypersensitivity (Allergy) 01/01/2018 - "Identification of T cell epitopes in allergy can be achieved by a variety of methods. " 10/29/2014 - "Mice immunized with a low dose of pCI-neo-sOVA-loaded CO₃Ap (10 μg) produced ex vivo splenocyte proliferation after stimulation with CD8 T-cell but not CD4 T-cell epitopes and a delayed-type-hypersensitivity reaction more efficiently than mice in the other groups. " 06/01/2013 - "Clinical development of ASIT for allergy has been instructive, but limited understanding of CD4 T cell epitope/determinant hierarchies hampers the rational design and monitoring of ASIT. " 07/01/2009 - "A synopsis of T-cell epitope mapping, with emphasis on the relevance to allergy is presented. " 09/15/2008 - "Three dimensional structure directs T-cell epitope dominance associated with allergy."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Vaccines
3.	Proteins (Proteins, Gene)
4.	Epitopes
5.	Antigens
6.	Protein Subunit Vaccines
7.	Antibodies
8.	Synthetic Vaccines (Recombinant Vaccines)
9.	Allergens
10.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Oral Administration
4.	Immunomodulation
5.	Intranasal Administration