CD34 Antigens (CD34 Antigen)

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.

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Networked: 154 relevant articles (3 outcomes, 18 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Chyczewski, Lech: 2 articles (03/2014 - 01/2004)
2.	Olszewska, Ewa: 2 articles (03/2014 - 01/2004)
3.	Qiu, Hui-Ying: 2 articles (10/2013 - 07/2009)
4.	Terada, Tadashi: 2 articles (03/2011 - 01/2009)
5.	Jeleń, Michał: 2 articles (02/2004 - 01/2004)
6.	Pati, Hara Prasad: 1 article (12/2014)
7.	Somasundaram, Venkatesan: 1 article (12/2014)
8.	Sazawal, Sudha: 1 article (12/2014)
9.	Ranjan, Ravi: 1 article (12/2014)
10.	Mishra, Pravas Chandra: 1 article (12/2014)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/01/1993 - "The expression of the CD34 antigen on the blast cells of acute myeloid leukemia (AML) has been regarded as an unfavorable prognostic factor for the achievement of complete remission (CR). " 06/04/2004 - "The expression of CD34 antigen in acute myelogenous leukemias is considered an unfavourable prognosis marker for response to anticancer drugs and duration of remission. " 07/01/1997 - "We can conclude that in leukemic hematopoiesis, CD34 antigen expression does not have the same significance as it does in normal hematopoiesis since clonogenic cells are not restricted to the CD34+ acute myeloid leukemia (AML) blast cell fraction. " 07/01/1997 - "In 141 adult patients with diagnosis of acute myeloid leukemia the overall expression and intensity of expression of CD34 antigen on leukemic cells was investigated. " 07/01/1997 - "The prognostic significance of CD34 antigen expression in acute myelogenous leukemia (AML) is controversial. "
2.	Neoplasms (Cancer) 01/01/2007 - "ER-negative tumors have significantly greater CD34 antigen expression compared to ER-positive tumors." 10/01/2001 - "Presently ultrastructural studies show absence of epithelial-mesothelial features, and reactivity of the tumor cells to CD34 antigen on immunohistochemical analysis suggests the mesenchymal origin of such tumors. " 03/01/1998 - "In this study, CTGF gene expression in mesenchymal tumors was investigated by in situ hybridization and CD34 antigen expression was studied by means of immunohistochemical staining. " 01/01/1994 - "In this study we evaluated the distribution of CD34 antigen in tumors of the central and peripheral nervous system. " 09/21/2012 - "Consecutive sections stained for the CD133 and CD34 antigens showed that the CD133+ and CD34+ VEGFR2 cells were mostly recruited to HCC tissue and concentrated in tumor microvessels. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/01/1999 - "[Study on the expression of myeloid markers and CD34 antigen in adult acute lymphoblastic leukemia]." 01/01/1998 - "Long-term follow-up of the rate of CD10, CD19 and CD34 antigens expression compared with the percentage of lymphocytes and blastic cells in 196 bone marrow specimens of 91 children with early B-cell acute lymphoblastic leukemia has been performed. " 01/01/1997 - "Expression of the CD34 antigen is a positive prognostic factor in childhood ALL. " 01/01/1997 - "Adult and childhood acute lymphoblastic leukemia: clinico-biological differences based on CD34 antigen expression." 01/01/1997 - "Beta-1-integrin expression in adult acute lymphoblastic leukemia: possible relationship with the stem cell antigen CD34."
4.	Carcinoma (Carcinomatosis) 09/01/2007 - "The presence or preservation of CD34 antigen in four totally male breast carcinomas may be considered as a novel finding that supports a relationship between these tumours and the progenitor CD34-positive stem cells, committed to the organogenesis of mammary gland. " 04/01/2005 - "45 invasive breast carcinomas were immunohistochemically stained with the endothelial antigen, CD34, and macrophage marker, CD68. " 05/01/1999 - "In order to determine whether tumor angiogenesis is a prognostic factor in gallbladder carcinoma patients, microvessels in selected areas (a 200x field, 0.74 mm2) in specimens resected from 40 patients with gallbladder carcinomas were identified by immunostaining endothelial cells for the endothelial antigen CD34 and counted. " 01/01/2007 - "The objective of this study was to evaluate angiogenesis according to CD34 antigen expression in estrogen receptor (ER)-positive and negative breast carcinomas. " 12/26/2006 - "277 specimens of gastric diseases, 56 specimens of chronic gastritis, 50 specimens of chronic atrophic gastritis, 59 specimens of intestinal metaplasia, 61 specimens of dysplasia, 57 specimens of gastric carcinoma with lymph node metastases, and 55 specimens of gastric carcinoma without lymph node metastases, obtained from pathological department, Sun Yat-sen university, underwent pathological examination and immunohistochemistry to detect the expression of CD34 antigen that is expressed only in the endothelial cells in tumor. "
5.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/01/1994 - "Flow cytometry studies have shown that high expression of CD34 antigen in patients with chronic myeloid leukemia (CML) is indicative of accelerated or blastic phases. " 01/01/1991 - "The expression of progenitor cell associated antigen CD34 was investigated in cells from 28 patients with chronic myeloid leukemia (CML). " 01/01/1991 - "Expression of hematopoietic progenitor cell associated antigen CD34 in chronic myeloid leukemia." 07/01/1992 - "Pluripotent hemopoietic stem cells, progenitors of all hemolymphopoietic lineages, and clonogenic cells from many patients with acute nonlymphocytic leukemia (ANLL) and chronic myeloid leukemia (CML) express the CD34 antigen on their surface. " 01/01/1996 - "The review gives the basic characteristics of the antigens CD34, CD33, CD7, Thy-1, HLA-DR, and nonstrain-limited antigens expressed on the hemopoietic precursors and provides data on the expression of these antigens on the blast cells of patients with chronic myeloid leukemia (CML). "

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9.	Antigens
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Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
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3.	Remission Induction
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5.	Heterologous Transplantation (Xenotransplantation)