CD14 Antigens

Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.

Also Known As:

Networked: 92 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Yang: 3 articles (01/2015 - 08/2005)
2.	Fassbender, Klaus: 3 articles (01/2015 - 08/2005)
3.	Walter, Silke: 3 articles (01/2015 - 08/2005)
4.	de Gruijl, Tanja D: 2 articles (10/2015 - 01/2015)
5.	Jordanova, Ekaterina S: 2 articles (10/2015 - 01/2015)
6.	Heeren, A Marijne: 2 articles (10/2015 - 01/2015)
7.	Kenter, Gemma G: 2 articles (10/2015 - 01/2015)
8.	Altosaar, Illimar: 2 articles (03/2006 - 11/2005)
9.	Blais, David R: 2 articles (03/2006 - 11/2005)
10.	Letiembre, Maryse: 2 articles (01/2006 - 08/2005)

Related Diseases

1.	Inflammation 05/01/2010 - "IPE cells express a functional LPS receptor complex and are capable of promoting ocular inflammation through secretion of an array of proinflammatory mediators. " 02/01/2009 - "Since zebrafish are in intimate contact with microorganisms, the high resistance of fish to LPS suggests that there must be a tight control of the LPS receptor cluster in order to avoid an excess of inflammation. " 10/01/2008 - "Being an adhesion molecule, CD18 is pivotal in inflammation and, moreover, exiting data suggest that CD18 is a lipopolysaccharide (LPS) receptor. " 01/01/2004 - "[Expression of the lipopolysaccharide receptors in the rat liver cells in inflammation and in norm]." 01/01/1999 - "The fact that these myeloid-derived cells have the ability to express the LPS receptor CD14 in the brain may well explain the transcriptional activation of the cytokine in response to the bacterial endotoxin, but not to systemic localized inflammation."
2.	Endotoxemia 11/01/1995 - "Furthermore, the alpha-form of the soluble CD14 LPS receptor in pig serum showed a marked decrease in LPS-treated animals, and this decrease was reduced by MTP-PE pretreatment at 24 h before endotoxemia was induced. " 05/01/2000 - "The present data provide the evidence that microglial-derived TNF-alpha is responsible for the production of the LPS receptor CD14 during endotoxemia. " 09/15/2002 - "There is a robust and transient innate immune response in the brain during endotoxemia, which is associated with a cascade of NF-kappaB signaling events and transcriptional activation of genes that encode TNF-alpha and the LPS receptor CD14. "
3.	Shock 02/01/1996 - "Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo." 12/01/2013 - "Activation of the LPS receptor complex by native lipid A induces robust cytokine production, leukocyte activation, and inflammation, which is beneficial for clearing bacterial infections at the local level but can cause severe systemic inflammation and shock at higher challenge doses. "
4.	Bacterial Infections (Bacterial Infection) 02/01/2009 - "We determined previously that hepatic P450 mRNAs are selectively regulated in a mouse model of enteropathogenic bacterial infection, and that this regulation was not dependent on the lipopolysaccharide (LPS) receptor protein toll-like receptor 4 (TLR4). " 12/01/2013 - "Activation of the LPS receptor complex by native lipid A induces robust cytokine production, leukocyte activation, and inflammation, which is beneficial for clearing bacterial infections at the local level but can cause severe systemic inflammation and shock at higher challenge doses. "
5.	Chromosome Aberrations (Chromosome Abnormalities) 06/15/1996 - "Factors associated with an increased likelihood of shorter remission duration were CD7 expression on leukemic cells (P=0.007) and an abnormal karyotype (P=0.010; those predicting shorter EFS were a chromosomal status other than normal (P=0.002) and detection of CD14 antigen (P=0.008). "

Related Drugs and Biologics

1.	Lipid A
2.	Toll-Like Receptor 4
3.	Cytokines
4.	Toll-Like Receptors (Toll-Like Receptor)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Antigens
7.	Interleukin-1beta (Interleukin 1 beta)
8.	Transforming Growth Factor beta1 (TGF beta 1)
9.	Scavenger Receptors (Scavenger Receptor)
10.	Superoxide Dismutase

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Renal Dialysis (Hemodialysis)