Chemokine CCL5

A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.

Also Known As:

Networked: 1849 relevant articles (40 outcomes, 248 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Weber, Christian: 11 articles (03/2014 - 09/2002)
2.	Ben-Baruch, Adit: 9 articles (01/2015 - 02/2002)
3.	Nomura, Shosaku: 8 articles (11/2014 - 07/2002)
4.	Conti, P: 8 articles (10/2014 - 07/2000)
5.	Nelson, Peter J: 7 articles (04/2015 - 06/2003)
6.	Tang, Chih-Hsin: 7 articles (02/2015 - 03/2009)
7.	Zhang, Yan: 6 articles (10/2015 - 03/2002)
8.	Pelli, Graziano: 6 articles (08/2012 - 02/2004)
9.	Mach, François: 6 articles (08/2012 - 02/2004)
10.	Proudfoot, Amanda E I: 6 articles (03/2008 - 03/2002)

Related Diseases

1.	Infection 12/01/2012 - "[Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China]." 01/01/2012 - "Despite the high prevalence of HBV infections in Saudi Arabia, no studies have been made concerning a possible relationship between RANTES gene polymorphisms and susceptibility to and progression of HBV infection. " 01/01/2012 - "Association studies have invariably indicated a lack of association between RANTES gene SNPs and HBV infection in ethnic populations, even though RANTES gene SNPs exhibit distinct ethnic distributions. " 07/01/2011 - "In this study, we demonstrate a crucial role for RANTES in the control of systemic chronic LCMV infection. " 01/01/2011 - "Previous studies have demonstrated that infection with porcine reproductive and respiratory syndrome virus (PRRSV) induces RANTES transcription in vitro and in vivo. "
2.	Inflammation 04/01/2006 - "Preclinical toxicity studies carried out with Swiss Webster mouse and New Zealand White rabbit vaginal irritation models demonstrated minimal inflammation and minimal adverse changes in cervicovaginal tissue integrity after short-term (10 min) and long-term (24 h) exposure to formulations containing up to 1 mg/ml of -2 RANTES. " 10/01/2000 - "Our studies highlight a hitherto unappreciated role for RANTES in neutrophil trafficking during inflammation. " 02/26/2015 - "The chemokine RANTES plays a key role in inflammation, cell recruitment and T cell activation. " 02/01/2015 - "Interaction between RANTES and its receptor C-C chemokine receptor (CCR) 5 is related to recruitment of macrophages to sites of inflammation. " 01/01/2015 - "As RANTES is discussed in the literature as a possible contributor to inflammatory diseases, and though it might have oncogenic effects, we hypothesize that FDOJ in areas of improper and incomplete wound healing in the jawbone might act as hyperactivated signaling pathways, while serving as an unknown source of "silent inflammation". "
3.	Neoplasms (Cancer) 02/01/2001 - "Plasma RANTES levels were found to be higher in order of stages IV, III, II, and I of each cancer except for stage I. A marked increase in plasma RANTES level (> 10,000 pg/ml) was found in 27% of patients with progressive malignancy but in none of those in clinical remission. " 04/01/2015 - "Therapeutic application of (131)I in RANTES-NIS-MSC-treated mice resulted in a significant delay in tumor growth and improved overall survival. " 03/01/2013 - "Administration of a therapeutic dose of (131)I or (188)Re (55.5 MBq) in RANTES-NIS-MSC-treated mice resulted in a significant delay in tumor growth and improved survival without significant differences between (131)I and (188)Re. " 04/01/2015 - "Although RANTES/CCL5-NIS targeting has shown efficacy in the treatment of primary tumors, it was not clear if it would also be effective in controlling the growth of metastatic disease. " 02/01/2001 - "In addition, in patients with progressive breast or cervical cancer, but not in patients thought to be cured of these tumors, the RANTES content was markedly increased in clinically normal tissue taken from near the operative site several months postoperatively, as well as in intact skin or mucosa taken perioperatively near the excised tumor. "
4.	Asthma (Bronchial Asthma) 12/01/2000 - "Patients with asthma attacks exhibited higher RANTES levels than those in remission. " 10/01/2014 - "Genetic studies have revealed that the regulated upon activation normal T-cell expressed and secreted (RANTES) -28C/G and -403G/A polymorphisms are associated with asthma risk, but contradictory findings have also been reported. " 01/01/2014 - "The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis. " 01/01/2014 - "A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. " 01/01/2012 - "The purpose of this study was to investigate the genetic influence of -403A and -28G alleles of the RANTES promoter region on the development of asthma in Lebanon. "
5.	Acquired Immunodeficiency Syndrome (AIDS) 08/01/1996 - "When expressed as a quantity per peripheral blood CD8+ lymphocyte, AIDS patients exhibited significantly greater levels of MIP-1 alpha, MIP-1 beta and RANTES than non-progressing HIV patients (P < 0.05). " 07/01/2008 - "In contrast, the RANTES haplotype H1, which lacks suspected deleterious single-nucleotide polymorphisms, was protective against AIDS. " 04/01/2008 - "Recent studies have reported that two single nucleotide polymorphisms (SNPs) in the RANTES gene promoter region, -403G/A and -28C/G, are associated with a slower rate of decline in CD4(+) T-cell number, whereas genetic polymorphisms within the CCR5 promoter are linked to acceleration of AIDS progression. " 01/01/2009 - "These results provide in vivo evidence of SIV evolution toward RANTES resistance in macaques rapidly progressing to AIDS. " 01/01/2009 - "In contrast, SIV isolates obtained from two singly-infected macaques, none of which progressed to AIDS, maintained HHV-6A/RANTES sensitivity, whereas the only AIDS progressor among singly-infected macaques developed an SIV variant with partial HHV-6A/RANTES resistance and increased replication capacity, associated with expanded coreceptor usage. "

Related Drugs and Biologics

1.	Chemokines
2.	Interleukin-8 (Interleukin 8)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Chemokine CCL4
5.	CC Chemokines
6.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
7.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
8.	Cytokines
9.	Interleukins
10.	Interleukin-5 (Interleukin 5)

Related Therapies and Procedures

1.	Homologous Transplantation (Allograft)
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Lung Transplantation
4.	Transplantation (Transplant Recipients)
5.	Injections