Chemokine CCL5

A CC-type chemokine that is a chemoattractant for EOSINOPHILS; MONOCYTES; and LYMPHOCYTES. It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. Chemokine CCL5 is specific for CCR1 RECEPTORS; CCR3 RECEPTORS; and CCR5 RECEPTORS. The acronym RANTES refers to Regulated on Activation, Normal T Expressed and Secreted.

Also Known As:

Networked: 2424 relevant articles (53 outcomes, 318 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lechner, Johann: 11 articles (01/2021 - 01/2013)
2.	Ben-Baruch, Adit: 11 articles (01/2020 - 02/2002)
3.	Weber, Christian: 11 articles (03/2014 - 09/2002)
4.	von Baehr, Volker: 10 articles (01/2021 - 01/2013)
5.	Conti, P: 9 articles (10/2016 - 07/2000)
6.	Tang, Chih-Hsin: 8 articles (06/2016 - 03/2009)
7.	Nomura, Shosaku: 8 articles (11/2014 - 07/2002)
8.	Zhang, Yan: 7 articles (11/2016 - 03/2002)
9.	Nelson, Peter J: 7 articles (04/2015 - 06/2003)
10.	Herder, Christian: 7 articles (01/2011 - 12/2005)

Related Diseases

1.	Infections 01/01/2021 - "In vitro, RANTES was protective against HAV infection but resulted in upregulated TNF-α expression. " 01/01/2016 - "This meta-analysis suggests that RANTES -403G/A and -28C/G polymorphisms confer possible protection against HIV-1 infection, whereas In1.1T/C polymorphism may increase risk of HIV-1 infection, especially in Asians. " 04/06/2016 - "Only a few studies on improving the early diagnosis of severe neonatal infections have focused on the role of serum RANTES concentration (sRC). " 12/01/2012 - "[Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China]." 04/10/2012 - "Despite the high prevalence of HBV infections in Saudi Arabia, no studies have been made concerning a possible relationship between RANTES gene polymorphisms and susceptibility to and progression of HBV infection. "
2.	Inflammation (Inflammations) 01/01/2016 - "Contrary to reports suggesting a distinct T helper 2-associated inflammatory profile in AAA, this current study suggests a more-generalized pattern of inflammation, albeit with some potentially distinct features, including elevated plasma eotaxin and decreased plasma RANTES. " 04/01/2006 - "Preclinical toxicity studies carried out with Swiss Webster mouse and New Zealand White rabbit vaginal irritation models demonstrated minimal inflammation and minimal adverse changes in cervicovaginal tissue integrity after short-term (10 min) and long-term (24 h) exposure to formulations containing up to 1 mg/ml of -2 RANTES. " 10/01/2000 - "Our studies highlight a hitherto unappreciated role for RANTES in neutrophil trafficking during inflammation. " 11/08/2023 - "The MAP3K19-/- mice exhibited worsened eosinophilic inflammation and an increased production of RANTES in the airway epithelium compared with the wild-type mice. " 08/09/2019 - "RANTES concentrations also correlated significantly with hepatic pathology scores of inflammation (r = 0.417, p = 0.008). "
3.	Asthma (Bronchial Asthma) 12/01/2000 - "Patients with asthma attacks exhibited higher RANTES levels than those in remission. " 10/22/2021 - "Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. " 10/01/2014 - "Genetic studies have revealed that the regulated upon activation normal T-cell expressed and secreted (RANTES) -28C/G and -403G/A polymorphisms are associated with asthma risk, but contradictory findings have also been reported. " 01/01/2014 - "The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis. " 01/01/2014 - "A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. "
4.	Neoplasms (Cancer) 02/01/2001 - "Plasma RANTES levels were found to be higher in order of stages IV, III, II, and I of each cancer except for stage I. A marked increase in plasma RANTES level (> 10,000 pg/ml) was found in 27% of patients with progressive malignancy but in none of those in clinical remission. " 04/01/2015 - "Therapeutic application of (131)I in RANTES-NIS-MSC-treated mice resulted in a significant delay in tumor growth and improved overall survival. " 03/01/2013 - "Administration of a therapeutic dose of (131)I or (188)Re (55.5 MBq) in RANTES-NIS-MSC-treated mice resulted in a significant delay in tumor growth and improved survival without significant differences between (131)I and (188)Re. " 04/01/2015 - "Although RANTES/CCL5-NIS targeting has shown efficacy in the treatment of primary tumors, it was not clear if it would also be effective in controlling the growth of metastatic disease. " 10/15/2015 - "The tumor-promoting chemokine CCL5 has been implicated in malignant transformation of breast epithelial cells, with studies to date focusing mainly on basal-type breast cancers. "
5.	Necrosis 03/01/2019 - "Inhibition of tumour necrosis factor-α, interleukin-1β, and RANTES expression was observed in astrocytes treated with c9,t11CLA and t10,c12CLA. " 01/01/2011 - "In stretched K10(R156H) cells, higher p38 activation, higher release of tumour necrosis factor-α and RANTES but reduced interleukin-1β secretion compared with K10(wt) cells was observed. " 04/01/2000 - "Here we demonstrate that NO very efficiently suppressed interleukin-1beta- and tumour-necrosis-factor-alpha-induced RANTES expression in keratinocytes. " 06/01/2011 - "In this study, we aimed to analyze gene expression of chemokines including CCL5/RANTES, CXCL10/IP-10, CXCL13/BCA-1, and receptors of CCR5, CXCR3, CXCR5 in peripheral blood mononuclear cells (PBMCs) during acute renal allograft rejection Gene expression of all these chemokines and receptors in PBMCs were analyzed by real-time PCR from 14 stable recipients, 32 biopsy-proven acute rejection (AR), and 5 acute tubular necrosis (ATN). " 05/01/2012 - "In the co-culture model, CyP alone partially inhibited IL-1β secretion, but did not prevent tumour necrosis factor (TNF)-α secretion, whereas penicillin alone inhibited IL-1β and TNF-α but conversely did not reduce MCP-1 and RANTES secretion. "

Related Drugs and Biologics

1.	Chemokines
2.	Cytokines
3.	Interleukin-8 (Interleukin 8)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
6.	Chemokine CCL4
7.	CC Chemokines
8.	Interleukin-4 (Interleukin 4)
9.	Immunoglobulin E (IgE)
10.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Intravenous Infusions
3.	Therapeutics
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Injections