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Monocyte Chemoattractant Proteins

Chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.
Also Known As:
Chemoattractant Protein, Monocyte; Chemoattractant Proteins, Monocyte; Chemotactic Protein, Monocyte; Chemotactic Proteins, Monocyte; Protein, Monocyte Chemoattractant; Protein, Monocyte Chemotactic; Monocyte Chemoattractant Protein; Monocyte Chemotactic Protein; Monocyte Chemotactic Proteins
Networked: 700 relevant articles (10 outcomes, 62 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kolattukudy, Pappachan E: 7 articles (01/2021 - 02/2007)
2. Mukaida, Naofumi: 6 articles (07/2012 - 11/2002)
3. Guglielmotti, Angelo: 6 articles (01/2012 - 06/2005)
4. Egashira, Kensuke: 6 articles (04/2009 - 02/2003)
5. Jin, Zhuqing: 4 articles (01/2021 - 05/2013)
6. Liang, Jian: 4 articles (01/2021 - 12/2011)
7. Ishiwata, Yoshiro: 4 articles (07/2004 - 02/2003)
8. Matsushima, Kouji: 4 articles (07/2004 - 02/2003)
9. Jura, Jolanta: 3 articles (11/2021 - 03/2016)
10. Durbas, Małgorzata: 3 articles (01/2021 - 03/2016)

Related Diseases

1. Inflammation (Inflammations)
2. Infections
3. Uveitis
01/01/2010 - "Recent studies in Caucasian uveitis patients have shown an association with the -2518 A/G polymorphism of the monocyte chemoattractant protein (MCP)-1 gene. "
11/04/2011 - "Here we found anti-inflammatory effects of a novel peptide (GC31) from CTLD of TM in endotoxin-induced uveitis, which was characterized by a reduction of leukocyte counts, protein concentration, tumor necrosis factor (TNF)-α and monocyte chemoattractant protein (MCP)-1 levels in aqueous humor. "
06/01/2001 - "To determine the location of the CC chemokines macrophage inflammatory protein (MIP)-1alpha, monocyte chemoattractant protein (MCP)-1, and regulated on activation of normal T-cell-expressed and secreted (RANTES) during disease progression in experimental autoimmune uveitis (EAU) and their relationship with the presence of the T helper cell (Th)1-type cytokine IFNgamma. "
01/01/2011 - "We assessed the anti-inflammatory effect of PAPep on endotoxin-induced uveitis (EIU) in rats and demonstrated that intravitreal pretreatment of PAPep concentration-dependently attenuated clinical manifestation of EIU rats, reduced protein leakage and cell infiltration into the aqueous humor (AqH), suppressed tumor necrosis factor (TNF)-α, interleukin (IL)-6, intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein (MCP)-1 production in ocular tissues, and improved histopathologic manifestation of EIU. "
01/01/2014 - "Neutralizing rat anti-VEGF antibodies significantly decreased ocular VEGF levels but did not decrease the endotoxin-induced uveitis (EIU) clinical score or the number of infiltrating cells and cytokines in ocular media (interleukin [IL]-1β, IL-6, tumor necrosis factor [TNF]-α, and monocyte chemoattractant protein [MCP]-1). "
4. Endometriosis
5. Vascular System Injuries
11/01/2011 - "We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth muscle cell proliferation and migration and neointimal macrophage content, effects associated with the inhibition of MCP-1/CCL2 production. "
01/01/2012 - "Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial. "
11/01/2007 - "The effect of a calcium channel blocker (CCB) on the expression of monocyte chemoattractant protein (MCP)-1 was explored in inflammatory vascular injury, focusing on the role of nuclear factor (NF)-kappaB. "
01/01/2006 - "That adipose tissue releases a wide range of adipokines, growth factors, enzymes, and enzyme substrates linked to vascular injury provides a plausible explanation for the role of fat in vascular disease: tumor necrosis factor-alpha, leptin, resistin, interleukin-1, -6, -8, and -18, serum amyloid A, monocyte chemoattractant protein I, macrophage inhibitory factor, aortic carboxypeptidase, hepa-rin-binding epidermal growth factor-like growth factor, vascular endothelial growth factor, transforming growth factor beta, angiotensinogen, cathepsin S, estradiol, cortisol, mineralocorticoid releasing factor, and calcitonin peptides are probable fat-derived prothrombotic, proinflammatory, and proatherosclerotic agents acting in a paracrine and/or endocrine manner. "

Related Drugs and Biologics

1. Interleukins
2. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3. Cytokines
4. Proteins (Proteins, Gene)
5. Interleukin-6 (Interleukin 6)
6. Interferons
7. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8. Interferon-gamma (Interferon, gamma)
9. C-Reactive Protein
10. Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1. Punctures
2. Ligation
3. Laser Therapy (Surgery, Laser)
4. Tooth Movement Techniques
5. Lasers (Laser)