Macrolides

A group of macrocyclic compounds formed by chain extension of multiple PROPIONATES and cyclized into a large (typically 12, 14, 16) membered lactone. They are often glycosylated. Many of them are ANTIBIOTICS.

Also Known As:

Networked: 1197 relevant articles (137 outcomes, 129 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rubin, Bruce K: 8 articles (06/2012 - 12/2003)
2.	Kohno, Shigeru: 7 articles (10/2015 - 04/2004)
3.	Kudoh, Shoji: 7 articles (12/2013 - 01/2002)
4.	Sunazuka, Toshiaki: 5 articles (10/2015 - 01/2006)
5.	Yamaya, Mutsuo: 5 articles (10/2015 - 03/2009)
6.	Mukae, Hiroshi: 5 articles (01/2014 - 04/2004)
7.	Azuma, Arata: 5 articles (12/2013 - 06/2002)
8.	Jahnz-Rózyk, Karina: 5 articles (04/2010 - 11/2007)
9.	Omura, Satoshi: 4 articles (10/2015 - 01/2006)
10.	Yanagihara, Katsunori: 4 articles (10/2015 - 01/2010)

Related Diseases

1.	Infection 05/01/2011 - "The main aim of their use is to treat infection, but anti-inflammatory properties of macrolides are also beneficial in selected diseases. " 07/01/2006 - "If a good outcome cannot be attained using the beta-lactam antimicrobial agent for otorhinolaryngological infection, it should be sought using a macrolides antimicrobial agent or the new quinolone antimicrobial agent for adults and with the macrolides antimicrobial agent for pediatric cases." 12/01/1996 - "Although therapy of many NTM infections remains difficult with somewhat unpredictable results, the introduction of newer drugs, particularly the macrolides, has appreciably improved a previously dismal outlook for successful therapy." 11/01/1993 - "Newer products with improved features have recently been discovered and developed, maintaining or significantly expanding the role of macrolides in the management of infection. " 06/01/2011 - "Combined maternal and single IA administration of macrolides may be a more effective regimen for treatment of intrauterine, but not fetal, infection."
2.	Asthma (Bronchial Asthma) 01/01/2010 - "In some of the studies on eradication with macrolides promising results have been gained in terms of asthma control, but in most of the cases improvement was only temporary." 01/01/2005 - "To determine whether macrolides are effective in the management of patients with chronic asthma. " 01/01/2005 - "To determine whether macrolides are effective in the management of patients with chronic asthma. " 01/01/2002 - "To determine whether macrolides are effective in the management of patients with chronic asthma. " 07/01/2012 - "Macrolides have antimicrobial and anti-inflammatory properties that may be useful in the treatment of chronic asthma. "
3.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/2004 - "Macrolides have broad antibacterial spectrum and proven efficacy in the management of respiratory tract infections. " 07/01/1996 - "Recently, low dose and long term use of Macrolides (Mls) has been reported to be effective in treatment of chronic lower respiratory tract infections, however its mechanism is still obscure. " 03/01/1995 - "Many respiratory infections are caused by obligate or facultative intracellular pathogens, which may be eradicated as a result of intracellular penetration and accumulation of macrolides, as shown in several models of phagocytic cells, and of intracellular antibacterial activities. " 04/01/2012 - "This study suggests that aerosol formulation of macrolides is an effective pulmonary drug delivery system for the treatment of respiratory infections." 11/01/2008 - "The potential indications for treatment lower respiratory tract infections with macrolides were presented in this study."
4.	Inflammation 03/01/2004 - "The main question regarding the future prospects of this class of drugs is whether some macrolides are beneficial in such settings because they modulate host inflammatory responses (and cellular targets) or rather because they eliminate a latent, unidentified pathogen which triggers chronic inflammation. " 01/01/2012 - "These secondary anti-inflammatory activities of macrolides appear to be particularly effective in attenuating neutrophil-mediated inflammation. " 03/01/2009 - "The long-term, low-dose therapy with the 14-membered macrolides is well known to be effective for treatment of chronic airway inflammation. " 11/01/2005 - "While, to date, several evidences have indicated that the mechanisms by which 14-membered ring macrolides reduce inflammation are not simply bactericidal, these results suggest another new mechanism of efficacy of macrolides in treating chronic rhinosinusitis." 03/01/2012 - "Although the methods and experimental model systems used in these studies are very heterogeneous, macrolides in general tempered inflammation caused by viable and non-viable bacteria or their products. "
5.	Pneumonia (Pneumonitis) 05/01/2007 - "In this study, we determined whether the ability of macrolides to regulate inflammatory processes is beneficial for innate resistance to macrolide-resistant pneumococci in a murine pneumonia model. " 04/01/2014 - "CRP was the only significant factor in predicting the efficacy of macrolides in patients with MRMP pneumonia. " 01/01/2014 - "The macrolides therapy might be beneficial for the patients with macrolide-resistant Mp pneumonia via not bacteriological but immunomodulative effects. " 04/01/2014 - "Serum CRP could be a useful marker for predicting the efficacy of macrolides and helping clinicians make better clinical decisions in children with MRMP pneumonia." 10/01/2015 - "Infants ≤29 completed weeks with signs and symptoms suggesting ureaplasma pneumonia who received macrolides comprised the study group. "

Related Drugs and Biologics

1.	Diffuse panbronchiolitis
2.	Anti-Bacterial Agents (Antibiotics)
3.	Azithromycin (Zithromax)
4.	Clarithromycin (Biaxin)
5.	Erythromycin (Erycette)
6.	Penicillins (Penicillin)
7.	Tetracyclines
8.	Quinolones
9.	Fluoroquinolones
10.	Cephalosporins (Cephalosporin Antibiotics)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Highly Active Antiretroviral Therapy (HAART)
3.	Aftercare (After-Treatment)
4.	Chest Tubes (Chest Tube)
5.	Length of Stay