Chemokines

Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif.

Also Known As:

Networked: 8631 relevant articles (120 outcomes, 784 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Van Damme, Jo: 38 articles (06/2015 - 07/2002)
2.	Weber, Christian: 30 articles (12/2015 - 04/2002)
3.	Struyf, Sofie: 29 articles (06/2015 - 07/2002)
4.	Strieter, Robert M: 29 articles (01/2014 - 04/2002)
5.	Luster, Andrew D: 28 articles (10/2015 - 04/2002)
6.	Aukrust, Pål: 27 articles (04/2014 - 04/2002)
7.	Mantovani, Alberto: 26 articles (03/2014 - 07/2002)
8.	Bhatia, Madhav: 24 articles (05/2012 - 01/2002)
9.	Ransohoff, Richard M: 21 articles (07/2015 - 04/2002)
10.	Proost, Paul: 20 articles (06/2014 - 07/2002)

Related Diseases

1.	Inflammation 12/15/1997 - "Although chemokines are clearly beneficial in wound healing, hemopoiesis, and the clearance of infectious organisms, the continued expression of chemokines is associated with chronic inflammation. " 08/01/2011 - "Receptor antagonists that block the binding of chemokines such as CXCL8 (IL-8) are effective in animals models of neutrophil-mediated inflammation. " 09/01/2009 - "Hence, this review was aimed to summarize possible roles of chemokines in the inflammation following SCI as well as to identify possible new therapeutical targets which can potentially be effective in ameliorating individual components of this inflammatory response. " 05/01/2000 - "By day 21, virus was cleared, inflammation reduced, and expression of all three chemokines subsided to baseline levels in the brains and spinal cords of resistant mice, and the brains of susceptible mice. " 09/01/2015 - "The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies. "
2.	Infection 02/15/2004 - "We then modeled partially effective postvaccination immune status 4 ways: use of PBMCs from highly exposed, uninfected individuals; depletion and partial reconstitution of autologous CD8+ cells from PBMCs from HIV-positive long-term nonprogressors; partial blocking of infection with chemokines; and variation in challenge virus dose. " 01/01/2013 - "During infections in neonates, the clearance of the parasite was preceded by a rapid recruitment of CD103+ DC mediated by CXCR3-binding chemokines produced by IEC in response to IFNγ. " 10/01/2006 - "In contrast, a significant reduction in CD4(+) T cell infiltration into the cornea was found in CXCL9 deficient mice following HSV-1 infection consistent with the absence of CXCL9 expression and reduction in expression of other chemokines including CCL3, CCL5, CXCL1, and CXCL10. " 03/17/2015 - "In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection." 03/01/2013 - "These data, along with improved phagocytosis by macrophages and increases in early/innate IL-1α, IFN-γ, and chemokines elicited in the lungs within 3 days of infection with the Δvad1 mutant, indicate that VAD1 expression reduces innate recognition of C. "
3.	Neoplasms (Cancer) 05/01/2005 - "Leukocyte recruitment under the pressure of chemokines may be beneficial for the host or for the tumor. " 01/01/2004 - "Leukocyte recruitment under the pressure of chemokines may be beneficial for the host or for the tumor. " 10/01/2015 - "DARC has been reported to inhibit the development of multiple cancers through clearance of angiogenic chemokines. " 09/15/2015 - "This study analyzed chemokines expressed by myeloma BM that are responsible for recruiting monocytes to the tumor bed. " 03/15/2015 - "In vitro study demonstrated that tumor-infiltrating miR-155(-/-) MDSCs showed greater migration ability and expressed higher level of multiple chemokines. "
4.	Asthma (Bronchial Asthma) 08/01/2015 - "5-LO-deficient mice exposed to intranasal rIL-13 also showed attenuated phenotypes of allergic asthma via significant reduction in Th2-specific chemokines, CCL7 and CCL17 production and decreased Th2 cells recruitment to the lungs. " 02/01/2008 - "The aim of the present study was to evaluate the role of Th1- and Th2- related chemokines in the pathogenesis of asthma exacerbation. " 01/01/2007 - "Chemokines and basement membrane changes characteristic of severe asthma are reported in a few studies. " 05/15/2005 - "In this study, we investigated (1) chemokine receptor expression by mast cells in the airway smooth muscle bundle in bronchial biopsies from subjects with asthma using immunohistology, (2) the concentration of chemokines in supernatants from stimulated ex vivo airway smooth muscle cells from subjects with and without asthma measured by enzyme-linked immunosorbent assay, and (3) mast cell migration toward these supernatants using chemotaxis assays. " 01/01/2003 - "Recent studies report that TARC and MDC may serve as pivotal chemokines for the development of Th2-dominated experimental allergen-induced asthma. "
5.	Arthritis (Polyarthritis) 01/01/2006 - "This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. " 07/01/2002 - "RA was chosen as a prototype to discuss these issues, as the majority of studies on the role of angiogenesis and chemokines in inflammatory diseases were carried out in arthritis. " 03/01/2013 - "There are several chemokines and their receptors involved in the pathogenesis of chronic inflammatory arthritis. " 09/01/2012 - "Fibroblasts were also the major early source of chemokines associated with polymorphonuclear leukocyte and monocyte/macrophage infiltration, thus providing a focal point for arthritis development. " 09/01/2011 - "Imbalance oxidative stress and chemokines are considered as a universal factors involved in the development of various clinical features seen in the patients with SLE and arthritis. "

Related Drugs and Biologics

1.	Cytokines
2.	Chemokine CCL5
3.	Chemokine Receptors
4.	Messenger RNA (mRNA)
5.	Interleukin-8 (Interleukin 8)
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
8.	Biological Markers (Surrogate Marker)
9.	Interleukins
10.	Interferons

Related Therapies and Procedures

1.	Immunotherapy
2.	Transplants (Transplant)
3.	Ligation
4.	Homologous Transplantation (Allograft)
5.	Drug Therapy (Chemotherapy)