Ischemic Optic Neuropathy (Anterior Ischemic Optic Neuropathy)

Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)
Also Known As:
Anterior Ischemic Optic Neuropathy; Posterior Ischemic Optic Neuropathy; Optic Neuropathy, Ischemic; Optic Neuropathy, Anterior Ischemic; Optic Neuropathy, Posterior Ischemic; Ischemia, Optic Nerve; Ischemias, Optic Nerve; Ischemic Optic Neuropathies; Nerve Ischemia, Optic; Nerve Ischemias, Optic; Neuropathies, Ischemic Optic; Neuropathy, Ischemic Optic; Optic Nerve Ischemias; Optic Neuropathies, Ischemic; Optic Nerve Ischemia
Networked: 507 relevant articles (20 outcomes, 59 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Optic Nerve Diseases (Optic Neuropathy)
2. Giant Cell Arteritis (Horton Disease)
3. Retinal Artery Occlusion
4. Ischemic Optic Neuropathy (Anterior Ischemic Optic Neuropathy)
5. Glaucoma


1. Bernstein, Steven L: 6 articles (12/2015 - 01/2007)
2. Savino, Peter J: 6 articles (04/2010 - 03/2003)
3. Miller, Neil R: 5 articles (12/2015 - 04/2010)
4. Guo, Yan: 5 articles (12/2015 - 01/2007)
5. Lee, Andrew G: 5 articles (10/2014 - 01/2007)
6. Nao-I, Nobuhisa: 5 articles (07/2013 - 05/2013)
7. Chuman, Hideki: 5 articles (07/2013 - 05/2013)
8. Lee, Michael S: 5 articles (04/2009 - 09/2002)
9. Foroozan, Rod: 5 articles (12/2008 - 03/2003)
10. Dickersin, Kay: 5 articles (10/2008 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ischemic Optic Neuropathy:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
2. SteroidsIBA
3. OxygenIBA
4. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
5. ranibizumab (Lucentis)FDA Link
6. Granulocyte Colony-Stimulating Factor (G-CSF)IBA
7. Arginine (L-Arginine)FDA Link
8. MethylprednisoloneFDA LinkGeneric
9. Alprostadil (Muse)FDA LinkGeneric
10. Endothelial Growth FactorsIBA

Therapies and Procedures

1. Decompression
2. Hemodilution
3. Intravitreal Injections
4. Hyperbaric Oxygenation
5. Blood Component Removal (Apheresis)