Sneddon Syndrome (Syndrome, Sneddon)

A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of livedo reticularis, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60)

Also Known As:

Networked: 35 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Stroke (Strokes)
2.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
3.	Hypertension (High Blood Pressure)
4.	Dyslipidemias (Dyslipidemia)
5.	Venous Thrombosis (Deep-Vein Thrombosis)

Experts

1.	Boëlle, Pierre-Yves: 1 article (05/2015)
2.	Muresan, Ioan-Paul: 1 article (05/2015)
3.	Bottin, Laure: 1 article (05/2015)
4.	de Zuttere, Dominique: 1 article (05/2015)
5.	Alamowitch, Sonia: 1 article (05/2015)
6.	Francès, Camille: 1 article (05/2015)
7.	Giannelou, Angeliki: 1 article (12/2014)
8.	Zhou, Qing: 1 article (12/2014)
9.	Kastner, Daniel L: 1 article (12/2014)
10.	Grigorovici, Mirela: 1 article (07/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sneddon Syndrome:

1.	Antiphospholipid AntibodiesIBA 07/01/1999 - "We conducted this study to compare the clinical and pathologic features of patients with Sneddon syndrome according to the presence or absence of antiphospholipid antibodies. " 12/01/2009 - "We discuss the nosology of this entity and its association with non-antiphospholipid antibody-related Sneddon syndrome. " 07/01/1999 - "Antiphospholipid antibodies-negative and -positive patients with Sneddon syndrome belong to close but different subsets of Sneddon syndrome." 07/01/1999 - "Sneddon syndrome with or without antiphospholipid antibodies. " 07/01/1998 - "[Antiphospholipid antibodies in a female patient with the Sneddon syndrome]."
2.	AntibodiesIBA 08/27/2005 - "Antimitochondrial type M5 antibodies (AMA-M5) are among the immunological abnormalities associated with Sneddon syndrome. " 08/27/2005 - "[Sneddon syndrome with anti-mitochondrial type M5 antibodies]." 01/01/1996 - "Endothelial antibodies (EAB) were determined by enzyme immunoassay in 39 patients with Sneddon syndrome. " 06/01/1992 - "[Sneddon syndrome with detection of anti-phospholipid antibodies]." 06/01/1990 - "[Sneddon syndrome: cardiac pathology and anti-phospholipid antibodies]."
3.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 04/01/2010 - "Detection of lupus anticoagulant and successful anticoagulation in familial Sneddon syndrome." 01/01/1990 - "Cutaneous thrombosis, cerebrovascular thrombosis, and lupus anticoagulant--the Sneddon syndrome. " 07/01/1999 - "Antiphospholipid antibodies-positive Sneddon syndrome was defined by the presence of lupus anticoagulant or abnormal titers of anticardiolipin antibodies on repeated determinations. "
4.	Retinaldehyde (Retinal)IBA 01/01/2012 - "Transient retinal venous and arterial occlusive events in a case of sneddon syndrome." 02/01/1987 - "Simultaneous bilateral central retinal arterial occlusion in a patient with Sneddon syndrome: case history." 01/01/2007 - "Diffuse retinal arterial occlusion, neovascularization, and vitreous hemorrhage as the presenting sign of sneddon syndrome: a 7.5-year angiographic follow-up." 01/01/2012 - "In addition, this case reports for the first time unusual fluorescein angiographic findings of incomplete branch retinal arterial occlusions, possibly associated with endothelial damage in Sneddon syndrome."
5.	Immunoglobulin M (IgM)IBA 01/01/1989 - "We report three patients with a Sneddon syndrome in whom predominantly small (500-900 kD) IgM-containing serum immune complexes were detectable. " 01/01/1989 - "In combined immunological investigation of 24 patients with Sneddon syndrome, 16 showed the decreased content of T-lymphocytes and theophylline-sensitive cells, increased content of B-lymphocytes, increased levels of IgM and circulating immune complexes. "
6.	Cardiolipins (Cardiolipin)IBA 03/01/1995 - "Anti-cardiolipin syndrome, Sneddon's syndrome, shrunken lung syndrome, sicca complex, thyrotoxicosis and myasthenia gravis were also present in this small group of patients. " 10/01/1988 - "[Sneddon syndrome (its association with anti-cardiolipin antibodies)]."
7.	Antigen-Antibody Complex (Immune Complex)IBA 01/01/1989 - "We report three patients with a Sneddon syndrome in whom predominantly small (500-900 kD) IgM-containing serum immune complexes were detectable. " 01/01/1989 - "In combined immunological investigation of 24 patients with Sneddon syndrome, 16 showed the decreased content of T-lymphocytes and theophylline-sensitive cells, increased content of B-lymphocytes, increased levels of IgM and circulating immune complexes. "
8.	factor V LeidenIBA 01/01/2003 - "Factor V Leiden mutation in Sneddon syndrome." 07/01/2010 - "[Sneddon syndrome associated with urticarial vasculitis and factor V Leiden mutation]."
9.	Fluorescein (Funduscein)FDA LinkGeneric 01/01/2012 - "We report a case with venous and arterial occlusive events in Sneddon syndrome and describe the accompanying fluorescein angiographic findings. " 01/01/2012 - "In addition, this case reports for the first time unusual fluorescein angiographic findings of incomplete branch retinal arterial occlusions, possibly associated with endothelial damage in Sneddon syndrome."
10.	Anticardiolipin AntibodiesIBA 07/01/1999 - "Antiphospholipid antibodies-positive Sneddon syndrome was defined by the presence of lupus anticoagulant or abnormal titers of anticardiolipin antibodies on repeated determinations. "

Therapies and Procedures

1.	Thyroidectomy 09/01/2008 - "Perioperative management of Sneddon syndrome during thyroidectomy."