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Interstitial Cystitis (Interstitial Cystitis, Chronic)

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A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.

Also Known As:

Interstitial Cystitis, Chronic; Cystitis, Interstitial; Chronic Interstitial Cystitis; Painful Bladder Syndrome; Chronic Interstitial Cystitides; Cystitides, Chronic Interstitial; Cystitides, Interstitial; Interstitial Cystitides; Interstitial Cystitides, Chronic; Cystitis, Chronic Interstitial

Networked: 951 relevant articles (106 outcomes, 134 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Interstitial Cystitis (Interstitial Cystitis, Chronic)
2.	Pain (Aches)
3.	Pelvic Pain
4.	Overactive Urinary Bladder (Overactive Bladder)
5.	Inflammation

Experts

1.	Kuo, Hann-Chorng: 30 articles (10/2015 - 01/2003)
2.	Parsons, C Lowell: 30 articles (04/2015 - 01/2002)
3.	Nickel, J Curtis: 17 articles (03/2015 - 03/2002)
4.	Yoshimura, Naoki: 14 articles (04/2014 - 01/2002)
5.	Chancellor, Michael B: 13 articles (12/2014 - 05/2002)
6.	Liu, Hsin-Tzu: 11 articles (05/2015 - 09/2007)
7.	Tyagi, Pradeep: 11 articles (05/2015 - 07/2006)
8.	Peters, Kenneth M: 10 articles (05/2015 - 08/2004)
9.	Theoharides, T C: 10 articles (12/2008 - 12/2000)
10.	van Ophoven, Arndt: 9 articles (12/2008 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Interstitial Cystitis:

1.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2015 - "To evaluate the clinical efficacy of bladder hydrodistention and intravesical sodium hyaluronate in the treatment of interstitial cystitis (IC). " 09/01/2006 - "In both studies uronate, glycosaminoglycan profile and hyaluronic acid levels significantly correlated with interstitial cystitis severity (p <0.001). " 07/01/2002 - "To study the clinical effect of diagnostic overdistension plus hyaluronic acid (HA) instillations in interstitial cystitis and the association of the clinical response with the intensity of intercellular adhesion molecule (ICAM)-1 expression. " 05/01/1997 - "On the assumption that interstitial cystitis (IC) is the result of a defective mucous lining of the bladder epithelium, a study was carried out to investigate the activity of hyaluronic acid (HA) in the treatment of IC. " 01/01/1997 - "Since interstitial cystitis (IC) might result from a defective glycosaminoglycan layer of the bladder epithelium, we conducted a trial of hyaluronic acid (HA), used intravesically, to test its activity in the treatment of this disease. "
2.	Pentosan Sulfuric Polyester (Pentosan Polysulfate)FDA Link 12/01/2008 - "Re: Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial: E. " 07/01/2008 - "Re: Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. " 01/01/2008 - "We examined the safety and the efficacy of a combination of intravesical and oral pentosan polysulfate sodium in comparison to only oral pentosan polysulfate sodium in treating interstitial cystitis. " 01/01/2008 - "Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial." 07/01/1997 - "To determine the efficacy of pentosan polysulfate (Elmiron) compared to placebo in the treatment of interstitial cystitis. "
3.	Heparin (Liquaemin)FDA LinkGeneric 05/01/2001 - "Although intravesical heparin instillation is effective in relieving symptoms in patients with frequency urgency syndrome and interstitial cystitis (IC), its efficacy has not been evaluated by urodynamic study. " 05/01/1994 - "In over half of the patients studied, intravesical heparin controls the symptoms of interstitial cystitis with continued improvement even after one year of therapy." 05/01/1994 - "To control the symptoms of interstitial cystitis with chronic self-administered intravesical heparin and determine whether the drug's continued use can sustain remission. " 09/01/2011 - "A total of 86 females with interstitial cystitis (IC) aged 26-52 years with the disease history over 2.7 years were exposed to intravesical electrostimulation in combination with electromagnetophoresis of heparin-containing mixture of medicines. " 10/01/2005 - "The subcutaneous administration of heparin appeared to be predominantly of value for patients with interstitial cystitis and an initial minor response to PPS."
4.	Amitriptyline (Elavil)FDA LinkGeneric 01/01/2009 - "From the existing studies amitriptyline may be effective in interstitial cystitis but publication bias should be considered as an alternative explanation. " 01/01/2010 - "We have conducted a prospective open-label study to examine the safety and efficacy of the long-term administration of the tricyclic antidepressant amitriptyline in patients with interstitial cystitis (IC). " 11/01/2005 - "We performed a prospective, open label study to examine the safety and efficacy of the long-term administration of the tricyclic antidepressant amitriptyline in patients with interstitial cystitis (IC). " 08/01/2004 - "We conducted a prospective study to examine the safety and efficacy of the tricyclic antidepressant amitriptyline in patients with interstitial cystitis (IC). " 01/01/2010 - "Long-term results of amitriptyline treatment for interstitial cystitis."
5.	Lidocaine (Xylocaine)FDA LinkGeneric 06/01/2001 - "Alkalinized intravesical lidocaine to treat interstitial cystitis: absorption kinetics in normal and interstitial cystitis bladders." 06/01/2001 - "Healthy volunteers and patients with interstitial cystitis had similar lidocaine absorption profiles with a peak of 1.06 microg/ml. (range 0.66 to 1.71) and 1.3 (range 0.2 to 2.0) at about 30 minutes. " 10/01/1996 - "Electromotive administration of intravesical lidocaine in patients with interstitial cystitis." 01/01/1989 - "Intravesical lidocaine in severe interstitial cystitis. " 05/01/2012 - "In human patients with interstitial cystitis, intravesical instillation of alkalinized lidocaine sometimes is associated with sustained amelioration of symptoms beyond the acute treatment phase. "
6.	Arginine (L-Arginine)FDA Link 03/01/2000 - "A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis." 02/01/1999 - "This randomized, double-blind, placebo controlled study further investigates the efficacy of L-arginine treatment for interstitial cystitis. " 09/01/1997 - "Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine." 11/01/2000 - "Re: A randomized double-blind trial of oral l-arginine for treatment of interstitial cystitis." 02/01/1999 - "A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis."
7.	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 07/01/1981 - "DMSO appears to be useful in the management of carefully selected patients with suspected early interstitial cystitis." 12/01/2000 - "A total of 21 patients, including 11 with classic and 10 with nonulcer interstitial cystitis, randomly underwent treatments with intravesical BCG or dimethyl sulfoxide and, if not improved, were treated with the other substance after a washout period. " 07/01/1988 - "To evaluate the effectiveness of dimethyl sulfoxide in the treatment of patients with biopsies suggestive of interstitial cystitis, 33 patients underwent a controlled crossover trial. " 07/01/1988 - "A controlled study of dimethyl sulfoxide in interstitial cystitis." 11/01/2012 - "Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail."
8.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 08/01/2003 - "The application of cyclophosphamide to rats was used to induce interstitial cystitis. " 01/01/2014 - "We investigated whether extracorporeal shock wave (ECSW) therapy can attenuate cyclophosphamide (CYP)-induced acute interstitial cystitis (AIC) in rats. " 11/02/2012 - "Cyclophosphamide (CYP) induces an interstitial cystitis-like inflammation. " 01/01/2014 - "Extracorporeal shock wave therapy ameliorates cyclophosphamide-induced rat acute interstitial cystitis though inhibiting inflammation and oxidative stress-in vitro and in vivo experiment studies." 07/01/1990 - "Diversion was performed for diverse conditions, including radiation cystitis, cyclophosphamide cystitis, interstitial cystitis, incontinence and trauma. "
9.	Cyclosporine (Ciclosporin)FDA LinkGeneric 07/01/2006 - "Is ciclosporin an effective treatment for interstitial cystitis?" 06/01/2004 - "Cyclosporine A treatment was safe and effective in treating interstitial cystitis. " 05/01/2012 - "Interstitial cystitis: a rare manifestation of primary Sjögren's syndrome, successfully treated with low dose cyclosporine." 12/01/2005 - "In a previous retrospective analysis, cyclosporine A (CyA) was highly efficient in treating patients with interstitial cystitis. " 06/01/2004 - "We evaluated patients with interstitial cystitis who had been on cyclosporine A treatment for at least a year. "
10.	PotassiumIBA 08/01/2009 - "The potassium sensitivity test: a new gold standard for diagnosing and understanding the pathophysiology of interstitial cystitis." 03/01/2003 - "Patients with a clinical diagnosis of interstitial cystitis and a positive result on the Parsons potassium test were enrolled in the study. " 01/01/2003 - "Urodynamic study and potassium sensitivity test for women with frequency-urgency syndrome and interstitial cystitis." 01/01/2010 - "Their mean PUF score was 7. Thirty-three (78.5%) of the patients who underwent cystoscopic hydrodistention had glomerulations consistent with NIH criteria for interstitial cystitis, and 26 of these patients tested positive for potassium sensitivity. " 01/01/2008 - "An association between positive potassium sensitivity test (PST), epithelial permeability dysfunction (EPD) and painful bladder syndrome/IC (PBS/IC) has been reported but limited attention has been given to these relationships in the epidemiologic area. "

Therapies and Procedures

1.	Intravesical Administration 04/01/2006 - "The results of this pilot study indicate that BTX-A intravesical injections are effective in the short-term management of painful bladder syndrome. " 03/01/1998 - "A psychometric analysis of the University of Wisconsin Interstitial Cystitis Scale was conducted on 30 females previously enrolled in a phase II double-blind randomized controlled trial evaluating the efficacy of six weekly intravesical instillations of TICE BCG. " 02/01/2013 - "Is there enough evidence for the use of intravesical instillations of glycosaminoglycan analogues in interstitial cystitis?" 08/01/2012 - "In male Sprague-Dawley rats, interstitial cystitis was induced by intravesical instillation of protamine sulphate (2 mg in 200 μl saline for 30 min; n = 6). " 08/01/2006 - "Localization of the FGF-10 receptor to the superficial urothelial layer is clinically significant because intravesical administration of FGF-10 may provide the clinician a means to control the turnover of transitional epithelium in bladder disorders such as interstitial cystitis."
2.	Hyperbaric Oxygenation 05/01/2011 - "[Hyperbaric oxygenation in the treatment of patients with interstitial cystitis: clinical and morphological rationale]." 01/01/2010 - "[Hyperbaric oxygenation in combined treatment of interstitial cystitis]." 06/01/2007 - "Hyperbaric oxygen therapy for interstitial cystitis resistant to conventional treatments." 10/01/2006 - "A total of 30 treatment sessions of hyperbaric oxygenation appear to be a safe, effective and feasible therapeutic approach to interstitial cystitis. " 05/01/2011 - "We studied efficacy of hyperbaric oxygenation (HBO) in 8 patients with interstitial cystitis/painful bladder syndrome (IC/PBS). "
3.	Cystectomy 05/01/1998 - "Our study confirms that supratrigonal cystectomy with ileocystoplasty results in a good outcome in classic interstitial cystitis. " 09/01/2005 - "To point out the efficacy of supra trigonal cystectomy with orthotopic substitution iliocystoplasty in the treatment of advanced interstitial cystitis (IC). " 06/01/2014 - "Re: cystectomy for ulcerative interstitial cystitis: sequelae and patients' perceptions of improvement." 10/01/2013 - "To evaluate the outcomes after cystectomy for ulcerative interstitial cystitis (IC). " 10/01/2013 - "Cystectomy for ulcerative interstitial cystitis: sequelae and patients' perceptions of improvement."
4.	Transcutaneous Electric Nerve Stimulation (TENS) 02/01/1994 - "Long-term treatment of interstitial cystitis by transcutaneous electrical stimulation provides a conservative means of bringing the disease to remission. " 05/01/1985 - "Conservative management of chronic interstitial cystitis: transcutaneous electrical nerve stimulation and transurethral resection." 02/01/1994 - "Transcutaneous electrical nerve stimulation in classic and nonulcer interstitial cystitis." 01/01/1993 - "A prospective study on the symptomatic effect of traditional Chinese acupuncture treatment and transcutaneous nerve stimulation (TENS) of the tibial nerve in patients with interstitial cystitis is presented. " 04/01/1987 - "Transcutaneous electrical nerve stimulation in interstitial cystitis. "
5.	Electrocoagulation (Electrocautery) 01/01/2015 - "To characterize electrocautery (EC) as a valid treatment option in interstitial cystitis (IC) patients with Hunner ulcers (HUs). " 04/01/2014 - "Therapeutic efficacy of narrow band imaging-assisted transurethral electrocoagulation for ulcer-type interstitial cystitis/painful bladder syndrome." 04/01/2014 - "Editorial comment to Therapeutic efficacy of narrow band imaging-assisted transurethral electrocoagulation for ulcer-type painful bladder syndrome/interstitial cystitis." 04/01/2014 - "Our results showed that narrow band imaging-assisted transurethral electrocoagulation could be a valuable therapeutic alternative in patients with ulcer-type interstitial cystitis/painful bladder syndrome, with good efficacy and reduction of recurrence rate." 04/01/2014 - "A single-center, prospective clinical trial was carried out aiming to show the effectiveness of narrow band imaging-assisted transurethral electrocoagulation for ulcer-type interstitial cystitis/painful bladder syndrome. "