Opioid Peptides (Opioid Peptide)

The endogenous peptides with opiate-like activity. The three major classes currently recognized are the ENKEPHALINS, the DYNORPHINS, and the ENDORPHINS. Each of these families derives from different precursors, proenkephalin, prodynorphin, and PRO-OPIOMELANOCORTIN, respectively. There are also at least three classes of OPIOID RECEPTORS, but the peptide families do not map to the receptors in a simple way.

Also Known As:

Networked: 1161 relevant articles (26 outcomes, 140 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mousa, Shaaban A: 17 articles (01/2014 - 05/2002)
2.	Stein, Christoph: 17 articles (12/2012 - 05/2002)
3.	Schäfer, Michael: 16 articles (08/2013 - 05/2002)
4.	Bodnar, Richard J: 13 articles (12/2014 - 12/2002)
5.	Rittner, Heike L: 11 articles (01/2014 - 10/2003)
6.	Brack, Alexander: 11 articles (01/2014 - 10/2003)
7.	Machelska, Halina: 11 articles (12/2012 - 05/2002)
8.	Labuz, Dominika: 7 articles (12/2012 - 08/2003)
9.	Zagon, Ian S: 6 articles (03/2015 - 11/2009)
10.	Rittner, H L: 6 articles (01/2011 - 08/2001)

Related Diseases

1.	Pain (Aches) 04/22/2004 - "These results have shown that opioid peptides are effective also after local treatment, and that their peripheral use may be of therapeutic interest in long-term management of chronic pain." 11/01/2003 - "We hypothesized that targeted and localized expression of endogenous opioid peptide in the bladder could be useful for the treatment of bladder pain. " 09/01/2010 - "These white blood cells also contribute to protection against inflammatory pain by releasing opioid peptides. " 12/01/2013 - "This study explores publication trends in clinical and experimental studies of EA (1975-2011) for pain and non-pain research; EA use for different clinical conditions (1974-2012); and the relation of EA research, including stimulation frequency, to opioid peptide mechanisms. " 10/01/2003 - "Recent studies have revealed that N2O exerts its antinociceptive effect by inducing opioid peptide release in the brain stem, thereby activating the descending noradrenergic inhibitory neurons, which modulate pain processing in the spinal cord. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/2004 - "Opioid peptides, which can induce mammalian hibernation, may provide protection against subcellular and molecular changes during hypothermic myocardial ischemia. " 05/01/2004 - "The data support the previous notion that endogenous opioid peptides are involved in the pathophysiology of ischemic heart disease." 05/01/2004 - "There is substantial evidence indicating that endogenous opioid peptides are involved in the pathophysiology of myocardial ischemia and reperfusion. " 03/01/1994 - "These findings suggest that endogenous opiates do not play an important role in modulating symptoms in myocardial ischemia. " 03/01/1994 - "Reexamination of the role of endogenous opiates in silent myocardial ischemia."
3.	Neuralgia (Stump Neuralgia) 05/01/2009 - "Our research team found an effective strategy in treating neuropathic pain that resulted from interactions between leukocyte-derived opioid peptides and their receptors on peripheral sensory neurons. " 01/01/1995 - "The increase in immunoreactivity for the opioid peptide Met-ink, however, was only seen in the late phase of CCI, and may be specific for conditions associated with neuropathic pain and its resolution." 11/05/2015 - "In conclusion, intrathecal μ opioid peptide (MOP) and NOP receptor agonists relieved chemotherapy-induced neuropathic pain. " 03/11/2005 - "It was reported that electroacupuncture (EA) had potent analgesic effect on neuropathic pain by activating various endogenous transmitters such as the opioid peptides. " 07/15/2004 - "It was reported that electroacupuncture (EA) has analgesic effect on neuropathic pain, and the analgesic effect was mediated by the endogenous opioid peptides. "
4.	Body Weight (Weight, Body) 07/01/1984 - "None of the opioid peptides was effective when injected peripherally in doses of 400 pmol/g body weight. " 07/01/1997 - "It is concluded that in the lal munia, endogenous opioid peptides are important constituents of the neuroendocrine mechanisms that influence development of the testes and body weight." 09/01/1989 - "The possible role of endogenous opiates in the regulation of food intake was investigated by studying their influence on body weight of rat pups. " 09/01/1985 - "Opioid peptides in the brain are postulated to mediate the hunger component of the control of food intake and regulation of body weight and concentrations are increased in the pituitaries of genetically obese rodents. " 02/01/1982 - "The elevation of the opioid peptide content of the hypothalamus was temporally associated with a slowing in the rate of body weight increase. "
5.	Ischemia 05/01/2004 - "Additionally, endogenous opioid peptides released during ischemia also enhance ischemic tolerance. " 04/01/2004 - "Opioid peptide response to spinal cord stimulation in chronic critical limb ischemia." 09/01/2003 - "To examine the receptor specificity and the mechanism of opioid peptide-induced protection, we examined freshly isolated adult rabbit cardiomyocytes subjected to simulated ischemia. " 06/01/1991 - "Shorter sampling intervals (5 min) indicated that release of opioid peptide material into the extracellular environment occurs within the first 5 min of ischemia resulting from severance of the blood supply to the brain. " 03/01/1992 - "[Change in the opioid peptide level in the heart and blood plasma during acute myocardia ischemia complicated by ventricular fibrillation]."

Related Drugs and Biologics

1.	Enkephalins
2.	Morphine (MS Contin)
3.	beta-Endorphin (Endorphin, beta)
4.	Endorphins
5.	Opioid Analgesics (Opioids)
6.	Opioid Receptors (Opioid Receptor)
7.	Pro-Opiomelanocortin (Proopiomelanocortin)
8.	N-Methylaspartate (NMDA)
9.	Peptides
10.	Catecholamines

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Drug Therapy (Chemotherapy)
3.	Analgesia
4.	Transplantation (Transplant Recipients)
5.	Spinal Injections