Excitatory Amino Acids

Endogenous amino acids released by neurons as excitatory neurotransmitters. Glutamic acid is the most common excitatory neurotransmitter in the brain. Aspartic acid has been regarded as an excitatory transmitter for many years, but the extent of its role as a transmitter is unclear.

Also Known As:

Networked: 1301 relevant articles (29 outcomes, 144 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wong, Chih-Shung: 9 articles (04/2016 - 06/2002)
2.	Wen, Zhi-Hong: 7 articles (12/2013 - 03/2002)
3.	Jean, Y-H: 5 articles (11/2015 - 06/2007)
4.	Wen, Z-H: 5 articles (11/2015 - 06/2007)
5.	Saransaari, Pirjo: 5 articles (01/2013 - 09/2003)
6.	Chang, Yi-Chen: 5 articles (05/2006 - 06/2002)
7.	Wang, Jing: 4 articles (01/2022 - 01/2018)
8.	Guo, Xiaoli: 4 articles (01/2019 - 07/2015)
9.	Harada, Chikako: 4 articles (01/2019 - 07/2015)
10.	Harada, Takayuki: 4 articles (01/2019 - 07/2015)

Related Diseases

1.	Ischemia 03/01/2005 - "This methodology provides the possibility of evaluating the protection against the outflow of excitatory amino acids and against an acute motor disturbance, i.e.contralateral turning to the ischemic side in the first hours after ischemia in awake rats. " 01/01/2018 - "Several studies have demonstrated that excitatory amino acid carrier-1 (EAAC1) gene deletion exacerbates hippocampal and cortical neuronal death after ischemia. " 10/01/1991 - "Although considerable evidence supports a role for excitatory amino acids in the pathogenesis of ischemic neuronal injury, few in vivo studies have examined the effect of increasing durations of ischemia on the extracellular concentrations of these agents. " 12/01/2017 - "In the ST, ischemia was also able to cause an increase in excitatory amino acids that was reversed more efficiently by the treatments with MEM10/24H and EEEV200. " 01/15/2012 - "At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis. "
2.	Brain Ischemia (Cerebral Ischemia) 09/01/1991 - "Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. " 10/19/2001 - "This study suggested that altered brain energy metabolites and excitatory amino acids occurred during cerebral ischemia and and HBO regulated these striatal metabolites, which might contribute to the protective effect of HBO in cerebral ischemia." 04/01/1996 - "To study the changes of excitatory amino acid (EAA) in patients with cerebral ischemia. " 09/01/1995 - "Recently, studies have demonstrated in vitro, that D-2 agonist, at the level of striatum and retina, may represent a powerful signal to inhibit release of excitatory amino acids implicated in cerebral ischemia. " 12/24/1991 - "Previous studies have demonstrated that microdialysis is capable of detecting an abrupt and massive increase in extracellular K+ concentration ([K+]e) and a concomitant increase in extracellular concentration of excitatory amino acids (EAAs) during cerebral ischemia in the rat hippocampus in vivo. "
3.	Hypoxia (Hypoxemia) 09/27/2023 - "Identification of Non-excitatory Amino Acids and Transporters Mediating the Irreversible Synaptic Silencing After Hypoxia." 01/01/2021 - "Hypoxia-induced depression of synaptic transmission becomes irreversible by intracellular accumulation of non-excitatory amino acids." 01/01/2021 - "Genetic interactions regulate hypoxia tolerance conferred by activating Notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster." 01/01/2020 - "Sustained Hypoxia Alters nTS Glutamatergic Signaling and Expression and Function of Excitatory Amino Acid Transporters." 01/01/2020 - "Loss of excitatory amino acid transporter restraint following chronic intermittent hypoxia contributes to synaptic alterations in nucleus tractus solitarii."
4.	Hypothermia 10/01/2015 - "It is concluded that NO modulates the thermoregulatory response of NRM to hypothermia and may interact with excitatory amino acids in central skin blood flow regulation." 01/15/2013 - "Excitatory amino acid changes in the brains of rhesus monkeys following selective cerebral deep hypothermia and blood flow occlusion." 07/01/1996 - "By contrast, hypothermia reduced the release of all excitatory amino acids. " 05/01/1996 - "Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization." 02/01/2002 - "The objective of this study was to assess the effect of therapeutic moderate hypothermia on excitatory amino acids and metabolism by applying cerebral microdialysis in patients suffering from space-occupying middle cerebral artery infarction. "
5.	Seizures (Absence Seizure) 09/01/1992 - "These neurochemical findings were discussed in relation to previous studies of age-related alterations in excitatory amino acids (EAAs) and the role of EAA and NE in modulating limbic seizures. " 08/20/2015 - "An increase in the release of excitatory amino acids has consistently been observed in the hippocampus during seizures, both in humans and animals. " 09/01/2014 - "AE did not prevent QA-induced seizures; however, it prevented cellular death and disruption of excitatory amino acid transport. " 02/27/2013 - "Especially, dysfunction of excitatory amino acid transporter type 3 (EAAT3) can lead to seizures. " 01/01/2013 - "Hyperactivity of excitatory amino acid systems, insufficient GABAA receptor-mediated neurotransmission, and disturbances in intrinsic properties of neuronal membranes are still regarded as the most important mechanisms of seizures. "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Free Radicals
3.	N-Methylaspartate (NMDA)
4.	Excitatory Amino Acids
5.	Excitatory Amino Acid Antagonists
6.	AMPA Receptors (AMPA Receptor)
7.	Valproic Acid (Depakote)
8.	Aspartic Acid (Aspartate)
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Neurotransmitter Agents (Neurotransmitter)

Related Therapies and Procedures

1.	Therapeutics
2.	Catheters
3.	Tourniquets
4.	Sutures (Suture)
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)