HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Thyroid-Stimulating Immunoglobulins

Subscribe to New Research on Thyroid-Stimulating Immunoglobulins

Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.

Also Known As:

Immunoglobulins, Thyroid-Stimulating; Immunoglobulin, Thyroid-Stimulating; Thyroid Stimulating Antibody; Thyroid-Stimulating Immunoglobulin; Antibody, Thyroid Stimulating; Immunoglobulin, Thyroid Stimulating; Stimulating Antibody, Thyroid; Thyroid Stimulating Antibodies; Thyroid Stimulating Immunoglobulin; Thyroid Stimulating Immunoglobulins; Antibodies, Thyroid-Stimulating; Thyroid-Stimulating Antibodies

Networked: 457 relevant articles (22 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Blood Proteins: 4303
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Antibodies: 92632
        Autoantibodies: 18666
        Thyroid-Stimulating Immunoglobulins: 457
        Long-Acting Thyroid Stimulator: 273
        thyrotropin-binding inhibitory immunoglobulin: 187
        thyroid stimulation-blocking antibody: 66
        Thyroid-Stimulating Immunoglobulins: 457
        thyrotropin-binding inhibitory immunoglobulin: 187
        thyroid stimulation-blocking antibody: 66
    - Immunoproteins: 33
      - Immunoglobulins: 23980
        Antibodies: 92632
        Autoantibodies: 18666
        Thyroid-Stimulating Immunoglobulins: 457
        Long-Acting Thyroid Stimulator: 273
        thyrotropin-binding inhibitory immunoglobulin: 187
        thyroid stimulation-blocking antibody: 66
        Thyroid-Stimulating Immunoglobulins: 457
        thyrotropin-binding inhibitory immunoglobulin: 187
        thyroid stimulation-blocking antibody: 66
  - Globulins: 334
    - Serum Globulins: 75
      - Immunoglobulins: 23980
        Antibodies: 92632
        Autoantibodies: 18666
        Thyroid-Stimulating Immunoglobulins: 457
        Long-Acting Thyroid Stimulator: 273
        thyrotropin-binding inhibitory immunoglobulin: 187
        thyroid stimulation-blocking antibody: 66
        Thyroid-Stimulating Immunoglobulins: 457
        thyrotropin-binding inhibitory immunoglobulin: 187
        thyroid stimulation-blocking antibody: 66

Experts

1.	McLachlan, Sandra M: 8 articles (01/2015 - 01/2004)
2.	Rapoport, Basil: 8 articles (01/2015 - 01/2004)
3.	Chen, Chun-Rong: 5 articles (01/2015 - 01/2004)
4.	Banga, J Paul: 4 articles (06/2013 - 01/2003)
5.	Ochi, Yukio: 4 articles (01/2012 - 03/2002)
6.	Nagayama, Yuji: 4 articles (02/2006 - 01/2004)
7.	Kahaly, G J: 3 articles (07/2015 - 12/2010)
8.	Endo, Toyoshi: 3 articles (06/2013 - 12/2006)
9.	Kajita, Yoshihiro: 3 articles (01/2012 - 03/2002)
10.	Rapoport, B: 3 articles (04/2010 - 03/2004)

Related Diseases

1.	Graves Disease (Basedow Disease) 10/01/2002 - "Neonatal Graves' disease tends to resolve spontaneously within 3-12 weeks as maternal thyroid stimulating immunoglobulins are cleared from the circulation but subsequent development may be impaired by perceptual motor difficulties. " 08/01/2001 - "Spontaneous remission of Graves' disease during pregnancy is thought to be due to a reduction of thyroid-stimulating antibody activity. " 02/01/1999 - "Spontaneous remission of Graves' disease with a decrease of thyroid stimulating antibody (TSAb) activity is commonly observed in pregnancy. " 04/01/1987 - "Many reports of thyroid stimulating immunoglobulins (TSI) in relation to treatment of Graves' disease have been published and with variable results concerning prediction of permanent remission or relapse after therapy. " 06/01/1986 - "The data herein reported refer to 25 patients with Graves' disease in clinical remission, in whom we have attempted to correlate T cell subset imbalances, the presence of thyroid-stimulating antibodies (TSAb) and the outcome of the subsequent relapse. "
2.	Hyperthyroidism 10/31/1986 - "Thyroid-stimulating antibodies in patients with long-term remission of Graves' hyperthyroidism." 04/01/2014 - "Neonatal hyperthyroidism is usually a self-limited condition frequently associated with transplacental passage of thyroid stimulating antibodies secondary to maternal autoimmune disorders. " 01/01/2014 - "The neonate needs to be followed up closely as clinical signs of hyperthyroidism may occur as thyroid stimulating immunoglobulins continue to circulate in the neonate, while the serum levels of PTU decline. " 09/01/2011 - "Mice challenged with TSHR A-subunit plasmid resulted in high frequency (75%) of hyperthyroidism and thyroid-stimulating antibodies. " 03/01/2011 - "Accordingly, the relationship between TSH and serum thyroid stimulating immunoglobulin (TSI) was examined during follow-up of patients with Graves' hyperthyroidism. "
3.	Goiter 01/01/1996 - "Normal human thyroid tissue has been transplanted either as a control in experiments with benign and malignant goiter tissue, or for the study of thyroid tissue response to stimulators such as TSH or thyroid stimulating antibodies (TSAb). " 12/01/2004 - "Importantly, six of 30 mice had elevated T4 levels and goiter (5 of 6 with detectable thyroid-stimulating antibodies). " 01/01/2003 - "The fibroblast injection model in female AKR/N (H-2k) mice led to 70% of the animals developing thyroid-stimulating antibodies and their thyroid glands showed large goiters with histological features of thyroid cell activation characteristic of Graves' glands. " 01/01/1990 - "Intrathyroidal lymphocytes from non toxic multinodular goiter: no evidence for production of thyroid stimulating antibodies." 01/01/1990 - "Thyroid Stimulating Antibodies (TSAb) have been reported in sera of patients with nodular autonomous goiter, but their pathogenetic relevance is uncertain, since these findings could not be confirmed by others. "
4.	Graves Ophthalmopathy 12/01/1984 - "The application of a cytochemical bioassay to measure thyroid stimulating antibodies; a study of patients with euthyroid Graves' ophthalmopathy." 11/01/2011 - "Thyroid-stimulating immunoglobulins (TSIs) likely mediate Graves' ophthalmopathy (GO). " 11/01/2011 - "Clinical relevance of thyroid-stimulating immunoglobulins in graves' ophthalmopathy." 12/01/2006 - "A highly sensitive thyroid stimulating antibody assay based on stimulation of cAMP release from frozen porcine thyroid cells is also available, and is useful for the evaluation of Graves' ophthalmopathy. " 12/01/1997 - "Value of thyroid stimulating antibody in the diagnosis of thyroid associated ophthalmopathy of euthyroid patients."
5.	Thyrotoxicosis 01/01/2009 - "However, 8 weeks after the completion of therapy, he developed T3-Graves-like thyrotoxicosis, which was confirmed with a diffuse-uptake thyroid scan and positive thyroid stimulating immunoglobulin. " 09/01/2003 - "When a dosage reduction does not cause a decrease in fetal thyroid size, transplacental passage of thyroid-stimulating antibodies causing fetal thyrotoxicosis should be suspected." 06/01/2002 - "Pregnancies complicated by high values of maternal thyroid-stimulating immunoglobulin appear to be at risk of developing neonatal thyrotoxicosis." 06/01/2002 - "A maternal thyroid-stimulating immunoglobulin value at least 5 index units predicted neonatal thyrotoxicosis with a sensitivity of 100%, specificity of 76.0%, positive predictive value of 40.0%, and negative predictive value of 100%. " 06/01/2002 - "The relationship between maternal thyroid-stimulating immunoglobulin values and the development of thyrotoxicosis was examined. "

Related Drugs and Biologics

1.	Immunoglobulins (Immunoglobulin)
2.	Antithyroid Agents (Antithyroid Drugs)
3.	Thyrotropin Receptors (Thyrotropin Receptor)
4.	Antibodies
5.	Thyrotropin (Thyroid-Stimulating Hormone)
6.	Immunoglobulin G (IgG)
7.	Thyroglobulin
8.	Polyethylene Glycols (Polyethylene Glycol)
9.	anti-thyroglobulin
10.	Staphylococcal Protein A (A, Protein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Thyroidectomy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Investigational Therapies (Experimental Therapy)