CD18 Antigens

Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.

Also Known As:

Networked: 85 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fagerholm, Susanna C: 2 articles (09/2015 - 01/2015)
2.	Morrison, Vicky L: 2 articles (09/2015 - 01/2015)
3.	Peters, Thorsten: 2 articles (07/2008 - 01/2002)
4.	Scharffetter-Kochanek, Karin: 2 articles (07/2008 - 01/2002)
5.	Banerjee, Ena Ray: 2 articles (08/2007 - 04/2007)
6.	Papayannopoulou, Thalia: 2 articles (08/2007 - 04/2007)
7.	Bobeva, Yoana: 1 article (01/2022)
8.	Henson, Sian Mari: 1 article (01/2022)
9.	Lombardi, Vittoria: 1 article (01/2022)
10.	Malaspina, Andrea: 1 article (01/2022)

Related Diseases

1.	Infarction (Infarctions) 12/04/2001 - "This study was designed to define the safety and efficacy of a recombinant, humanized, monoclonal antibody to the CD18 subunit of the beta2 integrin adhesion receptors (rhuMAb CD18), in reducing infarct size in patients treated with a thrombolytic agent. "
2.	Periodontitis 01/01/2017 - "Null mutations of genes required for leukocyte cell-cell recognition and extravasation (e.g., Icam-1, P-selectin, Beta2-integrin/Cd18), for pathogen recognition and killing (e.g., Tlr2, Tlr4, Lamp-2), immune modulatory molecules (e.g., Cxcr2, Ccr4, IL-10, Opg, IL1RA, Tnf-α receptor, IL-17 receptor, Socs3, Foxo1), and proteolytic enzymes (e.g., Mmp8, Plasmin) cause periodontitis, most likely due to an inefficient clearance of bacteria and bacterial products. "
3.	Neoplasms (Cancer) 08/22/2006 - "This study therefore sought to investigate the effect of sFn on beta2 integrin mediated monocyte adherence and killing of tumor cells. " 08/15/2006 - "Flow cytometric expression of common antigens CD18/CD45 in blood from dogs with lymphoid malignancies: a semi-quantitative study." 09/01/2006 - "These tumors arose from splenic red pulp and bone marrow macrophages, which expressed major histocompatibility complex class II and the beta2 integrin, CD11d. " 08/01/2004 - "beta2 Integrin expression was not inducible on these tumour cell lines, but Western blotting demonstrated CD43 expression in all the cancer cell lines examined and cell surface expression was confirmed by flow cytometry. " 03/31/1999 - "To clarify the underlying mechanisms, we examined effects of Dex on the binding avidity of beta2 integrin on the neutrophil surface and how these might in turn affect neutrophil-to-tumor cell binding. "
4.	Graves Disease (Basedow Disease) 05/01/1995 - "In this study we evaluated the possible expression of CD11a and CD18 antigens on thyrocytes of patients with Hashimoto's thyroiditis and on thyrocytes of patients with Graves' disease and simple goiter as controls; we used both alkaline phosphatase immunostaining and indirect immunofluorescence on cryostatic tissue sections. " 10/01/2002 - "The aim of the study was to estimate the expression of beta1 integrin CD49d (very late antigen-4), beta2 integrin CD11a (lymphocyte function-associated antigen 1 alpha), L-selectin (CD62L), and intercellular adhesion molecule-1 [ICAM-1 (CD54)] on peripheral blood mononuclear cells in patients with Graves disease (GD) (n = 45, mean age 15.9 +/- 5.9 y), in patients with nontoxic nodular goiter (NTNG) (n = 25, mean age 15.2 +/- 5.7 y), and in sex- and age-matched healthy control subjects (n = 25, mean age 15.9 +/- 2.4 y). "
5.	Asthma (Bronchial Asthma) 04/01/2007 - "To provide further insight into the role of alpha4beta1/VCAM-1 pathway and to compare this to the role of beta2 integrin in the development of acute asthma phenotype, we used genetically deficient mice, in contrast to previous studies with anti-functional antibodies yielding ambiguous results. " 11/01/1998 - "In the present study, we examined the effect of ibudilast (KC-404), a novel anti-asthma agent, on beta2 integrin expression induced by PAF. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	adhesion receptor
3.	Fibrinolytic Agents (Antithrombotic Agents)
4.	P-Selectin
5.	Interleukin-17 Receptors
6.	Peptide Hydrolases (Proteases)
7.	Fibrinolysin
8.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
9.	Ligands
10.	Lymphocyte Function-Associated Antigen-1 (LFA-1)

Related Therapies and Procedures

1.	Diet Therapy (Therapy, Diet)
2.	Aftercare (After-Treatment)