Multiple Endocrine Neoplasia Type 2b (MEN 3)

Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Also Known As:
MEN 3; MEN2b; MEA 2b; MEA IIb; MEN III; MEN IIb; Mucosal Neuroma Syndrome; Multiple Endocrine Neoplasia, Type 2b; Multiple Endocrine Neoplasms Type 2b; Mucosal Neuroma Syndromes; Neuroma Syndrome, Mucosal; MEN 2b; Neoplasia, Multiple Endocrine Type 2b; Neoplasms, Multiple Endocrine Type 2b
Networked: 474 relevant articles (5 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Multiple Endocrine Neoplasia Type 2a (MEN 2)
2. Myocardial Infarction
3. Coronary Artery Disease (Coronary Atherosclerosis)
4. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
5. Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)


1. Takahashi, M: 5 articles (04/2014 - 01/2000)
2. Santoro, Massimo: 5 articles (08/2013 - 06/2002)
3. Wells, Samuel A: 5 articles (08/2013 - 01/2007)
4. Iwashita, T: 4 articles (04/2014 - 01/2000)
5. Moley, Jeffrey F: 4 articles (09/2013 - 05/2002)
6. Miccoli, Paolo: 3 articles (06/2015 - 12/2007)
7. Stratakis, C A: 3 articles (09/2014 - 05/2000)
8. Ichihara, M: 3 articles (04/2014 - 02/2000)
9. Qiao, S: 3 articles (04/2014 - 02/2000)
10. Saarma, Mart: 3 articles (08/2011 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Endocrine Neoplasia Type 2b:
1. N- (4- bromo- 2- fluorophenyl)- 6- methoxy- 7- ((1- methylpiperidin- 4- yl)methoxy)quinazolin- 4- amine (ZD6474)IBA
2. CholesterolIBA
3. Vitamin EFDA LinkGeneric
4. Factor IX (PTC)FDA LinkGeneric
5. bendamustineFDA Link
6. Codon (Codons)IBA
7. Protein Isoforms (Isoforms)IBA
8. Phosphotransferases (Kinase)IBA
9. DNA (Deoxyribonucleic Acid)IBA
10. Calcitonin (Calcitonin, Eel)FDA LinkGeneric

Therapies and Procedures

1. Transplants (Transplant)
2. Prostatectomy (Retropubic Prostatectomy)
05/01/1994 - "It is the cause of the commonest surgical procedure in older men (3 men in 10 may ultimately undergo prostatectomy). "
06/01/2015 - "The purpose of this study is to study the influence of radical prostatectomy (RP) for prostate cancer on work status and working life in men 3 years after surgery. "
01/01/1999 - "The twelve projects studied included: (1) a mass screening study using PSA as the initial test in 21,079 volunteers; (2) an investigation of the usefulness of normal and age-referenced PSA cut-offs in 1,618 men; (3) a PSA-based screening study of 2,272 asymptomatic blood donors; (4) an investigation of the evidence and significance of transition zone carcinoma in 340 men with negative digital rectal examination findings; (5) determination of percent free PSA in one retrospective and two prospective studies to determine the appropriate cutpoints for percent free PSA; (6) evaluation of the diagnostic benefit of PSA transition zone density in 308 screening volunteers; (7) a study of the impact of PSA-based screening on the percentage of incidental prostate carcinoma in 1, 543 men undergoing transurethral resection of the prostate; (8) an evaluation of the changes in total PSA and pathologic stages in radical prostatectomy over 5 years in a PSA-based mass screening program; (9) a study evaluating the probability of having prostate cancer given the patient's age, total PSA and digital rectal examination findings; (10) an evaluation of the correlation between preoperative predictors and pathologic features in radical prostatectomy specimens; (11) an investigation of the correlation of total PSA with pathologic stage and tumor volume in patients undergoing radical prostatectomy with low PSA cut-off level, and (12) a study whether age has an impact on the extension of prostate cancer. "
07/01/1993 - "In the present study these relationships were explored with nitric oxide synthase immunohistochemistry and reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemistry of select pelvic tissue specimens obtained from 4 men (3 at radical prostatectomy and 1 at autopsy). "
3. Thyroidectomy
4. Homologous Transplantation (Allograft)
5. Coronary Artery Bypass (Coronary Artery Bypass Surgery)