Proliferating Cell Nuclear Antigen (PCNA)

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

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Networked: 4700 relevant articles (114 outcomes, 648 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Wei: 16 articles (05/2015 - 01/2002)
2.	Rao, Chinthalapally V: 12 articles (12/2015 - 06/2006)
3.	Agarwal, Rajesh: 11 articles (08/2012 - 03/2002)
4.	Mohammed, Altaf: 9 articles (12/2015 - 12/2011)
5.	Malkas, Linda H: 9 articles (03/2015 - 09/2006)
6.	Myung, Kyungjae: 9 articles (01/2015 - 12/2006)
7.	Singh, Rana P: 9 articles (02/2014 - 03/2002)
8.	Katiyar, Santosh K: 9 articles (11/2010 - 03/2005)
9.	Agnantis, N J: 9 articles (09/2005 - 07/2000)
10.	Steele, Vernon E: 8 articles (10/2015 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2004 - "MCM3 antibody was the most specific for multiple human cancers, whereas proliferating cell nuclear antigen was relatively less effective in specificity, and Ki-67 failed to detect several human cancers. " 04/01/2013 - "Tumor growth was 94 % inhibited, with a marked decrease in both cellular proliferation (PCNA immunostaining) and angiogenesis (tumor microvessel density via CD31 immunostaining). " 09/01/1997 - "When patients with compromised skull and/or cranial nerves (T4 tumors), who had a very short survival, were eliminated from the analysis, only the mitotic index and proliferating cell nuclear antigen allowed discrimination of a subset of patients with poor prognoses. " 03/01/2005 - "Treated tumors showed a threefold smaller volume (P < 0.025) and a significant reduction of the mitotic index and of PCNA expression. " 06/01/2002 - "The mean tumor weight in the MCT group (222.6+/-51.5 mg, mean+/-SD) was significantly greater than that in the control group (126.7+/-19.7 mg, P<0.01) at postoperative day (POD) 5. Immunohistochemistry for anti-proliferating cell nuclear antigen showed the labeling index in the MCT group (90.4%) to be higher than that in the control group (76.7%, P<0.01). "
2.	Carcinoma (Carcinomatosis) 04/01/2005 - "In this study PCNA proved to be an independent prognostic indicator in predicting disease-free and overall survival in breast carcinoma patients." 01/01/2014 - "In the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and PCNA immunoreactivity in bladder urothelial carcinomas (UC). " 04/01/2009 - "The aim of our study was to determine the importance of p53, PCNA and Ki-67, evaluated by immunohistochemistry, in the treatment and prediction of the laryngeal carcinoma. " 07/01/2008 - "[Study of gastric carcinoma and PCNA and c-met gene abnormality]." 07/01/2002 - "[The study of expression of proliferating cell nuclear antigen and its gene in hypopharyngeal carcinoma]."
3.	Neoplasm Metastasis (Metastasis) 06/01/2009 - "A multivariate analysis identified two independent factors that significantly affected both disease-free and overall survival: lymph node metastasis and PCNA index. " 04/15/1996 - "Three variables including deep invasion, liver metastasis, and advanced stages were significantly greater for patients with high PCNA LI ( > 49.4%) than for patients with low PCNA LI ( < 49.4%). " 04/01/2009 - "The values of p53, PCNA and Ki-67 in the patients from this study are strongly correlated with the absence of the loco-regional lymph node metastases, by means of descriptive statistics (confidence level 95%). " 04/01/2003 - "In our study, there was some correlation in the grade of PCNA proliferating index(PI) with the clinical stages or cervical lymph node metastasis of NPCs. " 08/01/2001 - "This study showed that p53-negative or low-PCNA index patients have relatively good prognoses despite extensive lymph node metastasis."
4.	Inflammation 10/01/2002 - "However, further studies are needed to elucidate whether the PCNA expression within MALT in the eustachian tube and middle ear is associated with a mucosal immune response to inflammation as in OM." 11/01/2015 - "In addition, PRDX1 knockdown in astrocytes and microglia resulted in the decrease of PCNA expression after LPS stimulation, showing that PRDX1 promoted astrocyte and microglia proliferation after inflammation. " 09/01/2014 - "The digastric muscles had no abnormal tissue or inflammation, and PAX7, MyoD, and PCNA expression had returned to the baseline levels. " 10/01/2013 - "Correlation between inflammation and PCNA expression was not statistically significant (P ≥ 0.05). " 05/15/2012 - "For the evaluation of inflammation-induced cell proliferation in the bone marrow, proliferating cell nuclear antigen immunostaining was carried out in the bone marrow of mice. "
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/01/2015 - "Present study concluded that PCNA index can be used to assess the proliferation and aggressiveness in dysplasia and different grades oral squamous cell carcinoma." 03/01/2009 - "In this study, the expressions of Ror2 in the normal mucosa, the epithelium dysplasia, and squamous cell carcinoma (SCC) of the oral cavity were investigated, and possible differences in the expression patterns of Ror2 and of p53, Ki67, or PCNA were examined. " 01/01/2009 - "The present study compared the expression of proliferative (COX-2, Ki67 and PCNA) and angiogenic markers (CD34 and NG2) between preneoplastic bronchial squamous dysplasia lesions and invasive squamous cell carcinoma. " 08/01/2008 - "Expression of PCNA and bcl-2 in basaloid squamous cell carcinoma of the larynx: a controlled study." 11/01/2001 - "[A study on expression of CD44V6 and PCNA in squamous cell carcinomas]."

Related Drugs and Biologics

1.	Proliferating Cell Nuclear Antigen (PCNA)
2.	Biological Markers (Surrogate Marker)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Phosphotransferases (Kinase)
5.	DNA (Deoxyribonucleic Acid)
6.	Antigens
7.	Proteins (Proteins, Gene)
8.	Cyclins
9.	Caspase 3 (Caspase-3)
10.	Transferases

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Lasers (Laser)
4.	Transplantation (Transplant Recipients)
5.	Photochemotherapy (Photodynamic Therapy)