Transcription Factor AP-1 (Transcription Factor AP 1)

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

Also Known As:

Transcription Factor AP 1; AP-1; Activator Protein-1; AP-1 Enhancer Binding Protein; AP 1 Enhancer Binding Protein; Activator Protein 1; Enhancer-Binding Protein, AP-1; AP-1 Enhancer-Binding Protein

Networked: 2940 relevant articles (42 outcomes, 295 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic-Leucine Zipper Transcription Factors: 187
      - Transcription Factor AP-1: 2940
        NFAB complex: 2
  - DNA-Binding Proteins: 2009
    - Basic-Leucine Zipper Transcription Factors: 187
      - Transcription Factor AP-1: 2940
        NFAB complex: 2

Experts

1.	Wagner, Erwin F: 25 articles (12/2021 - 03/2002)
2.	Tang, Chih-Hsin: 19 articles (08/2021 - 09/2007)
3.	Colburn, Nancy H: 19 articles (01/2012 - 05/2002)
4.	Surh, Young-Joon: 14 articles (05/2013 - 05/2002)
5.	Dong, Zigang: 12 articles (01/2018 - 01/2003)
6.	Young, Matthew R: 12 articles (01/2012 - 06/2002)
7.	Cho, Jae Youl: 11 articles (04/2022 - 03/2013)
8.	Bakiri, Latifa: 11 articles (12/2021 - 01/2005)
9.	Brown, Powel H: 11 articles (01/2016 - 10/2002)
10.	Ding, Min: 10 articles (02/2022 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2008 - "However, this regulation was dramatically reduced in tumor cells and completely abolished in primary cells transfected with an HO-1 promoter construct containing mutations in both the E-box and the AP-1 site, suggesting that AP-1 factors and USF-2 may act in a cooperative manner. " 03/21/2017 - "Our findings demonstrate that the combination of HDACi's with chemical inhibitors of the AP-1 signaling pathway attenuate the inflammatory phenotype of fibroblasts and may improve the efficacy of HDACi in PDAC and, potentially, in other solid tumors rich in stroma." 01/31/2019 - "Our study found a linear trend relationship between the expression of AP-1 and tumor size. " 01/01/2017 - "Murine macrophage (RAW 264.7) and epidermal (JB6) cells stably transfected with AP-1 to study tumor promoting potential, were used to differentiate between the toxicological profiles of sintered ITO (SITO) and unsintered mixture (UITO). " 01/01/2017 - "Recent studies have suggested that JDP2 may function as a tumor suppressor through its suppressive action against the AP-1 complex, which is known to drive oncogenic signals in several human malignancies. "
2.	Inflammation (Inflammations) 01/15/2023 - "Conclusively, AP-1 played a more critical role in the inflammation cascade than STAT3 in ANIT-induced CLI. " 01/01/2023 - "This review discusses the role of four key TFs in inflammation, namely NF-κB, STATs, AP-1 and IRFs, and their potential for being targeted to treat RA." 01/01/2023 - "In sum, we showed that the aging-related transcriptional activation of Jun and Fos family members in AP-1 complex is conserved across immune tissues and long- and short-living mouse strains, possibly contributing to increased inflammation with age." 12/01/2022 - "Furthermore, KEGG pathway enrichment analysis revealed that the genes including DDO, GOT1, IDH1 and BBOX1 involved in energy metabolism and were significantly down-regulated, while some apoptosis- and inflammation-related genes such as DRONC, AP-1, and COX-2 were significantly up-regulated under AC + WD stress in comparison with those at normal control (all p < 0.05 or 0.01). " 03/24/2022 - "FOS, JUN, ATF3, and EGR1 and the AP-1 pathway may play key roles in inflammation and complications caused by CPB."
3.	Carcinogenesis 01/01/2019 - "In this study, we demonstrate that miR-155 expression is modulated by a feedback loop between Pdcd4, AP-1, and miR-155 which results in enhanced expression of miR-155 with a consequent progression of tongue tumorigenesis. " 09/15/2014 - "In the current study, we show for the first time that EISO-treatment of HaCaT keratinocytes results in a blockade of cell cycle progression as well as a concentration-dependent inhibition of UV-induced AP-1 activity, two major cellular effects known to drive skin carcinogenesis. " 06/01/2011 - "In this study, the experimental approach was to express a dominant negative p38α MAPK (p38DN) in the epidermis of SKH-1 hairless mice and assess UVB-induced AP-1 activation, COX-2 expression, and the skin carcinogenesis response in these mice compared to wild-type littermates. " 06/01/2010 - "In summary, our study supports potential roles for jun D, jun B, and fra-1 in the DER regulation of AP-1 function in the Sencar mouse skin carcinogenesis model." 03/01/2001 - "Our study examined the expression of AP-1 family members in keratinocytes derived from the rat-4NQO model of oral carcinogenesis in which extremes of epithelial differentiation and tumour cell aggressiveness are evident. "
4.	Prostatic Neoplasms (Prostate Cancer) 01/01/2021 - "In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun." 01/01/2019 - "JunD, a member of the AP-1 family, is essential for cell proliferation in prostate cancer (PCa) cells. " 11/01/2011 - "These results suggest that Egr-1 may promote prostate cancer development by modulating the activity of factors NF-κB and AP-1, which are involved in cell proliferation and apoptosis." 11/01/2009 - "The importance of AP-1 as a mediator of proliferation and radiation responses is demonstrated by the findings that the expression of JunD, Fra-1 and Fra-2 siRNAs in prostate cancer cells suppress these cellular responses. " 11/01/2009 - "Transcription factor AP-1 promotes growth and radioresistance in prostate cancer cells."
5.	Lung Neoplasms (Lung Cancer) 01/01/2023 - "Overall, the tailored CRISPRi screen profiled the impact of over 2000 genes on the survival of eight LUAD cell lines and identified the CASP8AP2 - AP-1 axis mediating lung cancer viability." 01/01/2022 - "AP-1 leads the way in lung cancer transformation." 01/01/2016 - "In addition, we confirmed that miR-663a could inhibit AP-1 activity and AP-1 component JunD was a direct target of miR-663a in lung cancer cells. " 01/01/2012 - "LOX-PP reduced expression of Blimp1 by binding to c-Raf and inhibiting activation of AP-1, thereby attenuating the migratory phenotype of lung cancer cells. " 05/17/2002 - "H(2)O(2)-induced AP-1 activation and its effect on p21(WAF1/CIP1)-mediated G2/M arrest in a p53-deficient human lung cancer cell."

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Transcription Factors (Transcription Factor)
3.	Proteins (Proteins, Gene)
4.	Cytokines
5.	Interleukin-6 (Interleukin 6)
6.	DNA (Deoxyribonucleic Acid)
7.	Antioxidants
8.	Phosphotransferases (Kinase)
9.	Mitogen-Activated Protein Kinases
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Acupuncture Points (Acupuncture Point)
5.	Renal Dialysis (Hemodialysis)