Interleukin-13

A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.

Also Known As:

Networked: 5629 relevant articles (244 outcomes, 623 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Puri, Raj K: 58 articles (01/2022 - 02/2002)
2.	McKenzie, Andrew N J: 39 articles (01/2021 - 02/2002)
3.	Brombacher, Frank: 38 articles (01/2021 - 10/2002)
4.	Rothenberg, Marc E: 38 articles (01/2021 - 06/2002)
5.	Izuhara, Kenji: 36 articles (09/2020 - 06/2002)
6.	Wynn, Thomas A: 36 articles (10/2019 - 01/2003)
7.	Elias, Jack A: 35 articles (01/2022 - 03/2002)
8.	Gelfand, Erwin W: 32 articles (01/2020 - 12/2002)
9.	Foster, Paul S: 30 articles (12/2021 - 06/2002)
10.	Takeda, Katsuyuki: 29 articles (01/2019 - 12/2002)

Related Diseases

1.	Asthma (Bronchial Asthma) 07/01/2002 - "To investigate the role of IL-13 in chronic asthma, using an improved experimental model of asthma that reproduces most of the morphological features of the human disease. " 10/01/2018 - "By defining a strict remission phenotype, we identified 3 SNPs to be associated with complete asthma remission, where 2 SNPs have plausible biological relevance in FRS2, CCT, IL1RL1, IL18R1 and IL13." 10/01/2023 - "Anti IL-4/IL-13 treatment significantly reduced asthma exacerbations and OCS use in the overall cohort, with a more pronounced ACT improvement in the remission group. " 03/01/2019 - "Furthermore, the serum IL-13 levels in the asthma remission group and acute asthma group were significantly higher than those in the healthy control group, and the serum IL-13 levels in acute asthma group were significantly higher than those in asthma remission group. " 09/01/2006 - "These data support the view that targeting IL-13 may be beneficial in the treatment of asthma."
2.	Inflammation (Inflammations) 11/27/2012 - "Compared to the asthmatic group, the BALF and serum levels of IL-13 were significantly lower [(34.7 ± 7.1) vs (105.0 ± 9.0) ng/L, (34.0 ± 4.7) vs (48.1 ± 6.1) ng/L] (both P = 0.000) and the number of CD4⁺CD25⁺Foxp3⁺ regulatory T cells increased in peripheral blood (8.0% ± 1.3% vs 5.1% ± 2.1%, P = 0.002) and airway inflammation was significantly relieved in the cell treatment group. " 05/10/2019 - "These results for the first time demonstrated that SBT exhibited protective effects on CS-induced airway inflammation and MUC5AC hypersecretion, which might be related to the downregulation of the IL-13/STAT6 signaling pathway." 05/01/2015 - "Ten original research articles were found, reporting promising results for some candidate genes in drug metabolism (TYMS, MTHFR), DNA repair (XRCC1, OGG1, CCND1) and inflammation (SOD2, TGFB1)/immunity (IL13) pathways, but with no firm conclusion. " 01/01/2007 - "Inhibition of IL-4/IL-13 does not enhance the efficacy of allergen immunotherapy in murine allergic airway inflammation." 08/17/2023 - "Clinical and animal studies revealed that IL-13 might be protective in the development of MASH through both the preservation of metabolic functions and Th2-polarized inflammation in the liver and the adipose tissue. "
3.	Atopic Dermatitis (Atopic Eczema) 08/31/2023 - "Targeting IL-13 is highly efficacious in patients with Th2-biased atopic dermatitis (AD), but inhibition of other inflammatory molecules might also limit disease. " 11/01/2023 - "IL-13 Activates Cutaneous Schwann Cells to Promote CCL7-Dependent Pruritic Signaling in Atopic Dermatitis." 02/08/2023 - "Targeting Interleukin 13 for the Treatment of Atopic Dermatitis." 01/01/2023 - "The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis." 11/01/2022 - "SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis."
4.	Infections 11/01/2014 - "This was due to IL-13 signaling that was advantageous for resolving MRSA infection via inhibition of IFN-γ, but was detrimental to the clearance of influenza virus. " 02/01/2014 - "IL-13 driven Th2 immunity is indispensable for host protection against infection with the gastrointestinal nematode Nippostronglus brasiliensis. " 01/01/2022 - "A human investigation and 2 mouse studies link IL-13 to protection from infection/immunopathology. " 05/01/2017 - "Quantification and expression studies of IL-13 gene in response to experimental infection with Haemonchus contortus in Garole and Sahabadi sheep." 01/01/2016 - "Collectively, our study for the first time reveals a pro-parasitic role of host Bcl-2 and the capacity of host-derived IL-13 to modulate NO levels during infection via Bcl-2. "
5.	Neoplasms (Cancer) 08/01/1995 - "Thus, anti-tumor effects of IL-13 in vivo most probably result from pleiotropic effects including recruitment of nonspecific cells and improved stimulation of immune-specific anti-tumor effectors." 11/01/2012 - "Our aim was partially realized with improved recognition of tumor and reduced but persisting activity against normal tissue IL13Rα1(+) cells by the IL13.E13K.R109K CAR. " 08/22/2017 - "Assessment of near-infrared fluorophores to study the biodistribution and tumor targeting of an IL13 receptor α2 antibody by fluorescence molecular tomography." 05/01/2015 - "This study indicates that IL13 can be efficiently delivered to the tumor neo-vasculature and that it mediates a potent anticancer activity in the two models of cancer investigated in this study. " 02/15/2013 - "Twenty studies including a total of 6713 cancer cases and 8693 controls for IL13 rs20541 polymorphism and 4081 cancer cases and 6202 controls for IL13 rs1800925 polymorphism were included in the meta-analysis. "

Related Drugs and Biologics

1.	Interleukin-4 (Interleukin 4)
2.	Cytokines
3.	Interleukin-5 (Interleukin 5)
4.	Immunoglobulin E (IgE)
5.	dupilumab
6.	Interleukins
7.	Monoclonal Antibodies
8.	Interleukin-10 (Interleukin 10)
9.	Interleukin-13
10.	Interleukin-17 (Interleukin 17)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Aftercare (After-Treatment)
5.	Injections