Bone Substitutes

Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.

Also Known As:

Networked: 206 relevant articles (7 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roos-Jansåker, Ann-Marie: 4 articles (11/2014 - 01/2007)
2.	Renvert, Stefan: 4 articles (11/2014 - 07/2007)
3.	Lindahl, Christel: 3 articles (11/2014 - 07/2007)
4.	Jäger, M: 3 articles (04/2014 - 05/2005)
5.	Schemitsch, Emil H: 2 articles (12/2015 - 08/2010)
6.	McKee, Michael D: 2 articles (12/2015 - 08/2010)
7.	Zins, James E: 2 articles (11/2015 - 10/2009)
8.	Götz, Werner: 2 articles (09/2015 - 03/2012)
9.	Giannoudis, P V: 2 articles (02/2014 - 03/2009)
10.	Colombo, M: 2 articles (02/2014 - 09/2011)

Related Diseases

1.	Pain (Aches) 04/01/2009 - "Drilling of the necrotic area followed by OWHTO with TomoFix and artificial bone substitute is an effective treatment for SONK as it results in pain alleviation and regeneration of the fibrous cartilage tissue over the necrotic legion. " 04/01/2008 - "Using a bone substitute, the operation can be performed as an outpatient procedure and donor-site pain avoided. " 01/01/2014 - "The use of a tricortical bone graft collected from the iliac crest is associated with pain at the harvest donor site in 2.8% to 39% of the cases, and this has been an impetus for many surgeons to use bone substitutes. " 10/01/2011 - "Clinical parameters such as pain visual analog scale (VAS), swelling, infection, graft migration, rejection, radiographical interpretations at regular interval and scintigraphic evaluation were done to evaluate osteogenic potential of alloplastic bone substitute with or without PRP. " 12/01/2008 - "Because of its limited supply and complications such as pain, bleeding or infection, the development of alternative bone substitutes has been the subject of several studies. "
2.	Wounds and Injuries (Trauma) 01/01/2011 - "The aim of this study was to investigate structural and in vitro mechanical properties of nine bone substitute cements registered for use in orthopaedic trauma surgery in the Netherlands. " 04/01/2014 - "Bone defects in the spine, methaphyseal defects after trauma/tumour and diaphyseal segmental defects are typical indications for the application of bone substitutes. " 09/01/2011 - "Inclusion criteria were articles in English language focusing on the use of bone substitutes in trauma and orthopaedic surgery for the treatment of bone defects and included details on the structural, biological or biomechanical properties of the pure product. " 09/01/2011 - "This paper presents the indications and applications of bone substitutes for metaphyseal defects and subchondral support in orthopaedic trauma." 02/01/2011 - "The aim of this systematic literature review was to provide a comprehensive overview of literature data of bone substitutes registered in the Netherlands for use in trauma and orthopedic surgery. "
3.	Scoliosis 04/01/2008 - "The aim of this study was to compare bioactive glass and iliac crest autograft as bone substitutes in the treatment thoracic adolescent idiopathic scoliosis (AIS). " 02/01/2009 - " harvesting of autologous bone continues to be the accepted standard to extend the local autograft in scoliosis surgery, there is a clear trend toward the use of bone substitutes." 02/01/2009 - " bone substitutes currently used in scoliosis surgery are presented, and their clinical significance is elucidated by a review of the literature. " 02/01/2009 - "[Bone substitutes in scoliosis surgery]." 04/01/2008 - "Bioactive glass as a bone substitute for spinal fusion in adolescent idiopathic scoliosis: a comparative study with iliac crest autograft."
4.	Osteonecrosis (Kienbock's Disease) 04/01/2009 - "We evaluated the clinical outcomes, in terms of early weight bearing, of using opening wedge high tibial osteotomy (OWHTO) to treat spontaneous osteonecrosis of the medial femoral condyle of the knee (SONK) using TomoFix and artificial bone substitute. " 08/01/2012 - "The purpose of our study is to describe the rationale, the surgical technique and the early clinical and radiographic results of the treatment of patients with early stage osteonecrosis of the femoral head (ONFH) by performing: core decompression, injection of autologous bone marrow concentrate and the use of a new composite injectable bone substitute (PRO-DENSE(®)), as a mechanical supplementation associated with decompression. " 03/01/2014 - "We evaluated the effect of initial stable fixation combined with an artificial bone substitute on the mid- to long-term outcome after medial opening-wedge high tibial osteotomy (HTO) for medial compartmental osteoarthritis or spontaneous osteonecrosis of the knee in 78 knees in 64 patients available for review at a minimum of five years (mean age 68 years; 49 to 82). " 02/01/2014 - "This long-term follow-up study confirmed that CD technique combined with recombinant morphogenetic proteins, autologous MSCs and xenograft bone substitute may be an effective treatment for patients with early stage osteonecrosis of the femoral head." 02/01/2014 - "To determine the efficacy of core decompression (CD) technique combined with recombinant morphogenetic proteins, autologous mesenchymal stem cells (MSCs) and xenograft bone substitute into the necrotic lesion of the femoral head on clinical symptoms and on the progression of osteonecrosis of the femoral head. "
5.	Gingival Recession 12/01/2005 - "Treatment with rhPDGF-BB stimulated a significant increase in the rate of CAL gain, reduced gingival recession at 3 months post-surgery, and improved bone fill as compared to a beta-TCP bone substitute at 6 months."

Related Drugs and Biologics

1.	beta-tricalcium phosphate
2.	Titanium
3.	Proteins (Proteins, Gene)
4.	platelet-derived growth factor BB (becaplermin)
5.	Durapatite (Hydroxylapatite)
6.	calcium phosphate
7.	Polymethyl Methacrylate (Sol)
8.	Calcium Sulfate (Alabaster)
9.	Polymers
10.	Bio-Oss

Related Therapies and Procedures

1.	Decompression
2.	Heterologous Transplantation (Xenotransplantation)
3.	Injections
4.	Transplants (Transplant)
5.	Curettage