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Abdominal Abscess

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An abscess located in the abdominal cavity, i.e., the cavity between the diaphragm above and the pelvis below. (From Dorland, 27th ed)

Also Known As:

Abdominal Abscesses; Abscess, Intra Abdominal; Abscesses, Abdominal; Abscesses, Intra-Abdominal; Intra-Abdominal Abscess; Intra-Abdominal Abscesses; Abscess, Abdominal; Abscess, Intra-Abdominal

Networked: 621 relevant articles (39 outcomes, 47 trials/studies)

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses
- Infection: 328407
  - Suppuration: 1749
    - Abscess: 10073
      - Abdominal Abscess: 621
        Liver Abscess: 880
        Subphrenic Abscess: 140

Related Diseases

1.	Infection
2.	Appendicitis
3.	Abscess
4.	Wound Infection (Wound Infections)
5.	Escherichia coli Infections

Experts

1.	Ren, Jianan: 5 articles (08/2015 - 08/2011)
2.	Gu, Guosheng: 5 articles (08/2015 - 08/2011)
3.	St Peter, Shawn D: 5 articles (08/2015 - 01/2010)
4.	Li, Jieshou: 5 articles (08/2015 - 08/2011)
5.	Chen, Jun: 5 articles (01/2015 - 07/2011)
6.	Han, Gang: 4 articles (01/2015 - 07/2011)
7.	Bemelman, W A: 3 articles (09/2015 - 06/2011)
8.	Sharp, Susan W: 3 articles (08/2015 - 01/2010)
9.	Wang, Gefei: 3 articles (08/2015 - 04/2014)
10.	Liu, Song: 3 articles (08/2015 - 12/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Abdominal Abscess:

1.	Clindamycin (Cleocin)FDA LinkGeneric 09/01/1997 - "We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. " 09/01/1989 - "Effects of clindamycin and gentamicin and other antimicrobial combinations against enterococci in an experimental model of intra-abdominal abscess." 09/01/1986 - "Effects of muramyl dipeptide and clindamycin in a murine abdominal abscess model." 09/01/1986 - "Murine abdominal abscesses were created by intraperitoneal injection of Bacteroides fragilis and autoclaved fecal suspensions, and the effects of MDP and clindamycin on these abscesses were evaluated. " 01/01/1987 - "Of the 51 patients receiving clindamycin-gentamicin, two had septic complications: one was an intra-abdominal abscess requiring surgery and one was a wound abscess requiring drainage. "
2.	Anti-Bacterial Agents (Antibiotics)IBA 10/01/2000 - "Laparoscopic drainage, in combination with systemic antibiotics, is a safe and effective treatment option in patients with postoperative complicated intra-abdominal abscesses." 09/01/1982 - "Although the patient had no localizing abdominal symptoms or signs, an intra-abdominal abscess was found and cured by surgical drainage and antibiotics. " 06/01/1995 - "coli within intra-abdominal abscess were observed for most antibiotics with the doses used in this study. " 06/01/1982 - "In the present study, the prime importance of prompt drainage and the secondary role of antibiotics in the treatment of intra-abdominal abscess are confirmed." 05/01/2015 - "Eight NOM patients underwent percutaneous drainage of abdominal abscess (median total duration of intravenous + oral antibiotics = 12 days [0-55]). "
3.	trovafloxacinIBA 01/01/2001 - "coli, trovafloxacin could be beneficial in the treatment of intra-abdominal abscesses." 03/01/1997 - "In vivo efficacy of trovafloxacin (CP-99,217), a new quinolone, in experimental intra-abdominal abscesses caused by Bacteroides fragilis and Escherichia coli." 12/01/1998 - "Drug concentrations were greater in intra-abdominal abscesses than in serum, reflecting the good tissue penetration of trovafloxacin. " 12/01/1998 - "In these experimental models, trovafloxacin protected rats from lethal infection, reduced intra-abdominal abscess formation, and inhibited bacterial growth. " 09/01/1997 - "We investigated the efficacy of trovafloxacin, a new quinolone, in comparison with that of clindamycin in the treatment of intra-abdominal abscesses caused by Bacteroides fragilis in young and senescent mice. "
4.	beta-Lactamases (beta-Lactamase)IBA 08/01/2015 - "Bacteriology of Spontaneous Intra-Abdominal Abscess in Patients with Crohn Disease in China: Risk of Extended-Spectrum Beta-Lactamase-Producing Bacteria." 12/01/2012 - "Extended-spectrum beta-lactamase (ESBL) producing organisms cause wide spectrum of diseases including urinary tract infection, cholangitis, intra-abdominal abscess or pneumonia but rarely meningitis. " 06/01/1991 - "Efficacy of different beta-lactams against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain in the rat intra-abdominal abscess model." 03/01/1993 - "We examined the efficacy of ampicillin-sulbactam (2:1) and cefoxitin in the treatment of infections caused by Escherichia coli strains exhibiting increasing levels of beta-lactamase-mediated resistance to ampicillin-sulbactam in the rat intra-abdominal abscess model. " 03/01/1995 - "We carried out bacteriological and clinical studies on tazobactam/piperacillin (TAZ/PIPC), a combination drug of piperacillin with the new beta-lactamase inhibitor tazobactam, in various infectious diseases in surgical field such as intra-abdominal infections (peritonitis and intra-abdominal abscess), hepatobiliary infections (cholecystitis, cholangitis and hepatic abscess) and secondary infections in wound, etc. The total number of cases treated with the combination drug was 164. "
5.	PolysaccharidesIBA 11/01/1994 - "Structural characteristics of polysaccharides that induce protection against intra-abdominal abscess formation." 04/01/2001 - "Compositional and immunochemical studies demonstrated a zwitterionic charge motif common to all of the capsular polysaccharides that correlated with their ability to induce experimental intra-abdominal abscesses. " 09/01/2008 - "Structural features of polysaccharides that induce intra-abdominal abscesses. " 11/01/1994 - "pneumoniae type 1 capsule protected against intra-abdominal abscesses subsequent to intraperitoneal challenge with each of these polysaccharides. " 10/15/1993 - "Structural features of polysaccharides that induce intra-abdominal abscesses."
6.	Metronidazole (Metric)FDA LinkGeneric 07/01/1994 - "Intra-abdominal abscesses, fistulous disease, and metronidazole or steroid therapy have all been reported to be important predisposing factors in the pathogenesis of the disease, and the mortality has been reported to be high. " 07/01/1994 - "None of the patients had intra-abdominal abscesses, active fistulas, or metronidazole therapy before the onset of symptoms. " 01/01/1983 - "There was no statistically significant difference in the overall frequency of postoperative septic complications (wound infection or intra-abdominal abscess) between the two groups, but wound infections were significantly fewer in the patients given metronidazole. " 02/01/2015 - "Efficacy and safety of metronidazole injection for the treatment of infectious peritonitis, abdominal abscess and pelvic inflammatory diseases in Japan." 04/01/1991 - "Postoperative intra-abdominal abscess were found in 1.4% of the patients who were then treated with antibiotics (metronidazole plus amicacin). "
7.	Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric 03/01/1981 - "intra-abdominal abscesses, occurred in both Cefoxitin-treated and placebo-treated patients, but numbers were too small for meaningful analysis. " 01/01/1986 - "The results seem to indicate that a 3-day course of cefoxitin is as effective as a 5-day course in controlling the incidence of wound infection following surgery for perforated or ruptured appendicitis, whereas the 3-day course seems to be inferior to a 5-day course in controlling the incidence of intra-abdominal abscesses." 03/01/1993 - "Efficacy of ampicillin-sulbactam versus that of cefoxitin for treatment of Escherichia coli infections in a rat intra-abdominal abscess model." 02/01/1984 - "However cefoxitin was significantly superior to ampicillin + metronidazole in preventing intra-abdominal abscesses (P less than 0.05). " 03/01/1993 - "We examined the efficacy of ampicillin-sulbactam (2:1) and cefoxitin in the treatment of infections caused by Escherichia coli strains exhibiting increasing levels of beta-lactamase-mediated resistance to ampicillin-sulbactam in the rat intra-abdominal abscess model. "
8.	Ciprofloxacin (Cipro)FDA LinkGeneric 01/01/1987 - "Therapeutic efficacy and pharmacokinetic properties of ciprofloxacin in intra-abdominal abscesses caused by Bacteroides fragilis and Escherichia coli." 09/01/2014 - "Providers should consider this high rate of ciprofloxacin resistance when choosing first-line antibiotic treatment for CD-related intra-abdominal abscesses." 09/01/2014 - "Microorganisms, their ciprofloxacin resistance, and clinical outcomes were retrospectively analyzed in 78 CD patients with intra-abdominal abscesses, who underwent percutaneous drainage between March 1991, and November 2011. " 09/01/2014 - "We attempted to identify the microorganisms present in CD-related intra-abdominal abscesses, their ciprofloxacin resistance patterns, and the clinical impact. " 01/01/1989 - "Activity of ciprofloxacin in the treatment of experimental intra-abdominal abscesses in mice."
9.	Rifampin (Rifampicin)FDA LinkGeneric 12/01/1984 - "Therapeutic efficacy and pharmacokinetic properties of rifampicin in a Bacteroides fragilis intra-abdominal abscess." 01/01/1987 - "The therapeutic efficacy of ciprofloxacin was investigated in this mixed intra-abdominal abscess model and was compared with that of rifampicin. " 12/01/1984 - "The efficacy of rifampicin in treating a Bacteroides fragilis infection was investigated and compared to clindamycin and metronidazole in an experimental model of intra-abdominal abscess in mice. "
10.	GalliumIBA 01/01/2005 - "The purpose of this study was to evaluate the efficacy of sonography and gallium scan in diagnosing intra-abdominal abscess after colorectal surgery and to compare these results with CT. " 01/01/2005 - "The limited use of ultrasound in the detection of abdominal abscesses in patients after colorectal surgery: compared with gallium scan and computed tomography." 03/01/1985 - "[Diagnosis of abdominal abscesses with gallium scintigraphy]." 12/01/1978 - "Gallium scanning for the detection of abdominal abscesses." 10/01/1976 - "The localization of multiple intra-abdominal abscesses by gallium scanning."

Therapies and Procedures

1.	Appendectomy 04/01/2007 - "The results suggest that intravenous triple antibiotic therapy alone is an efficacious first-line treatment in children developing intra-abdominal abscesses following appendectomy. " 01/01/2011 - "The purpose of this study is to determine if irrigation at appendectomy decreases the postoperative intra-abdominal abscess rate. " 04/01/2007 - "This study investigates a series of 26 children from 2 to 15 years of age presenting with one or more post-appendectomy intra-abdominal abscesses. " 06/16/2015 - "There were no intra-abdominal abscesses or other major complications associated with delayed appendectomy in patients randomized to antibiotic treatment. " 02/01/2015 - "The only postoperative complication consisted of an intra-abdominal abscess after laparoscopic appendectomy. "
2.	Catheters 05/01/2007 - "The catheter permanently has been put in 14 pts and the drainage extempore of abdominal abscesses has been made in 26 pts in 28 cases the process cleared up by the one only treatment (6 catheter and 22 percutaneous drainage), in 12 cases has been necessary more drainage treatments (in 4 cases the extempore drainage and in 8 cases the drainage + catheter). " 09/01/1986 - "This paper presents a study of 45 patients who had percutaneous catheter drainage of 52 intra-abdominal abscesses. " 03/01/2015 - "Herein, we describe a novel use of a dual-lumen central venous catheter to obtain percutaneous drainage of a postoperative intra-abdominal abscess. " 12/01/2012 - "Placement of percutaneous drainage catheters has become first-line therapy in the treatment of patients with intra-abdominal abscesses. " 01/01/2012 - "One patient showed multiple intra-abdominal abscesses requiring insertion of a pigtail catheter for drainage. "
3.	Laparotomy 04/01/1994 - "Six complications occurred in the postoperative period: abdominal infiltrate in two patients, which was cured by nonoperative measures, and an abdominal abscess in another two patients (one was treated by laparoscopic drainage and the other by laparotomy). " 05/01/2015 - "The abdominal abscess was drained via laparotomy and intra-abdominal vacuum therapy was performed with an open pore double-layered film using a vacuum pressure of - 75 mmHg. " 12/01/2012 - "No patient required a re-look laparotomy following IR for haemorrhage or intra-abdominal abscess. " 06/01/2010 - "A 29-year-old man underwent an emergent laparotomy for multiple intra-abdominal abscesses. " 06/01/2008 - "Laparotomy with removal of an intra-abdominal abscess, followed by closed postoperative continuous lavage for 10 days, was performed. "
4.	Sutures (Suture) 09/01/2015 - "Suture dehiscence (peritonitis and intra-abdominal abscess) showed a significant trend towards a higher local recurrence. " 10/01/2012 - "Seven cases (30%) had complications during the VAC® therapy: 3 intra-abdominal abscesses (13%), 4 fistulas or suture dehiscence (17%), and 1 evisceration (4%). " 07/01/2003 - "To assess the outcome of primary repair in penetrating colonic injuries in terms of regional/local morbidity (suture line breakdown, intra-abdominal abscess) and mortality. " 12/01/1988 - "Postoperative sepsis was caused by intra-abdominal abscess in 16 cases (53 per cent), by suture line leakage in 9 cases (30 per cent) and by technical error in 5 cases (17 per cent). " 10/01/2010 - "No significant differences occur between suture and stapler closure with respect to the pancreatic fistula or intra-abdominal abscess after distal pancreatectomy, though there is a trend favoring stapler closure."
5.	Thrombolytic Therapy 07/01/2012 - "Fibrinolytic therapy using tPA is effective in a rat model of intra-abdominal abscesses, has recently been reported for the treatment of intra-abdominal abscesses in adults, and is commonly used in the treatment of empyema in children. " 07/01/2012 - "The objective of this study is to assess the safety of fibrinolytic therapy using tissue plasminogen activator (tPA) in children with complex intra-abdominal abscesses. " 03/01/1988 - "To test the hypothesis that local fibrinolytic therapy can prevent the formation of intra-abdominal abscess, daily injections of the fibrinolytic enzymes trypsin and tissue plasminogen activator (t-PA) were administered intraperitoneally to Wistar rats inoculated intraperitoneally with infected fibrin clots. "