Hantavirus Infections

Infections with viruses of the genus HANTAVIRUS. This is associated with at least four clinical syndromes: HEMORRHAGIC FEVER WITH RENAL SYNDROME caused by viruses of the Hantaan group; a milder form of HFRS caused by SEOUL VIRUS; nephropathia epidemica caused by PUUMALA VIRUS; and HANTAVIRUS PULMONARY SYNDROME caused by SIN NOMBRE VIRUS.

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Networked: 155 relevant articles (5 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Leptospirosis
3.	Hemorrhagic Fever with Renal Syndrome (HFRS)
4.	Sepsis (Septicemia)
5.	Systemic Inflammatory Response Syndrome (Sepsis Syndrome)

Experts

1.	Vaheri, Antti: 23 articles (12/2015 - 03/2003)
2.	Vapalahti, Olli: 14 articles (07/2015 - 03/2003)
3.	Mustonen, Jukka: 11 articles (12/2015 - 10/2003)
4.	Mäkelä, Satu: 10 articles (12/2015 - 08/2010)
5.	Lundkvist, Ake: 8 articles (11/2015 - 10/2002)
6.	Yoshimatsu, Kumiko: 8 articles (07/2014 - 04/2009)
7.	Arikawa, Jiro: 8 articles (07/2014 - 04/2009)
8.	Laine, Outi: 6 articles (12/2015 - 08/2010)
9.	Henttonen, Heikki: 6 articles (07/2015 - 10/2003)
10.	Huhtala, Heini: 5 articles (12/2015 - 08/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hantavirus Infections:

1.	AntibodiesIBA 01/01/1989 - "The protective effects of passively administered antibodies against hantavirus infection were studied in newborn rats. " 11/20/2015 - "The aim of this study was to investigate the presence of Hantavirus antibodies in patients who had clinical and laboratory findings that were potentially associated with Hantavirus infection prior to the epidemic in Bartin in 2009. " 07/01/1999 - "To study the epidemiology of hantavirus infections in Austria, 1215 humans and 596 rodents of different species were tested for the presence of antibodies against Puumala and Hantaan virus. " 08/01/2015 - "This assay offers a new approach to evaluating and measuring neutralising antibodies produced during hantavirus infections and it can be adapted to other hantaviruses, including viruses that will be isolated in the future. " 07/01/2015 - "Serological survey of Seewis virus antibodies in patients suspected for hantavirus infection in Finland; a cross-reaction between Puumala virus antiserum with Seewis virus N protein?"
2.	Ribavirin (Virazole)FDA LinkGeneric 01/01/2013 - "Although highly effective in preventing ANDV replication and suppressing activation of select inflammatory mediators, the therapeutic efficacy of ribavirin is limited due to its inability to fully inhibit cytokine outburst triggered by hantavirus infection." 01/01/2014 - "Effectiveness of the ribavirin in treatment of hantavirus infections in the Americas and Eurasia: a meta-analysis." 10/01/2006 - "Recent studies have defined the incubation period of new world hantavirus infections, provided additional evidence for person-to-person transmission of Andes virus, described a rapid method for the presumptive diagnosis of infection in the cardiopulmonary phase through a review of the peripheral smear, and suggested that intravenous ribavirin is probably not effective for the treatment of new world hantavirus infections when started in the cardiopulmonary phase. "
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2006 - "In our study, genetically determined low production of TNF-alpha was associated with some parameters indicating a more severe clinical course of Puumala Hantavirus infection in humans, possibly by impaired activation of TNF-alpha-dependent antiviral mechanisms, which could in turn result in decreased clearance of Hantavirus." 01/01/2006 - "We studied a TNF-alpha single-nucleotide promoter polymorphism (SNP) at position -238 (a guanine [G]-to-adenine [A] transition) and ex vivo TNF-alpha production in a recall study of 36 Belgian patients who had a serologically proven form of Puumala virus-induced Hantavirus infection with the kidney as main target organ. "
4.	Hemagglutinins (Hemagglutinin)IBA 07/01/1999 - "Use of hemagglutinins of functionally active Hantaan strains in serologic studies notably improves the diagnostic efficacy of the hemagglutination test in Hantavirus infection."
5.	Nucleocapsid ProteinsIBA 10/01/2012 - "Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection." 02/01/2012 - "Application of truncated nucleocapsid protein (N) for serotyping ELISA of murinae-associated hantavirus infection in rats." 10/01/2011 - "The nucleocapsid protein (NP) of hantavirus has been shown to be highly immunogenic in laboratory animals and humans, and it induces an early and long-lasting humoral immune response during hantavirus infection. " 05/01/2010 - "Truncated hantavirus nucleocapsid proteins for serotyping Sin Nombre, Andes, and Laguna Negra hantavirus infections in humans and rodents." 01/01/2006 - "Serological assays for the detection of human andes hantavirus infections based on its yeast-expressed nucleocapsid protein."
6.	Immunoglobulin G (IgG)IBA 01/01/2012 - "An antibody prevalence study conducted in the region as part of the outbreak investigation showed 45 (9.1%) of 494 persons to be IgG positive, illustrating that hantavirus infection is common in Santa Cruz Department. " 07/01/2009 - "Seroconversion and rising anti-hantavirus IgG titers were taken as evidence of hantavirus infection. " 01/13/2007 - "This first survey on hantavirus-specific IgG in populations of eastern Switzerland revealed low seroprevalence-rates not significantly different among populations with higher risk for hantavirus infection (0.0%-1.9%) and the average adult population (0.5%). " 01/01/2007 - "No one from the group of patients with renal disorders was positive for hantavirus Puumala IgG. Moreover, none of the forest workers had evidence of hantavirus infection. " 09/01/1995 - "Five had IgG titers consistent with a previous hantavirus infection: 3 of these 5 were among the 43 patients who had illnesses similar to the HPS prodrome (P < .05). "
7.	AntigensIBA 12/01/2001 - "Using a more extensive range of hantavirus antigens, we conducted a seroprevalence study of rodents and humans and found further evidence of hantavirus infections. " 07/17/2014 - "Serological diagnosis with recombinant N antigen for hantavirus infection." 01/01/2014 - "These results indicated that the ICG test with the three representative antigens is an effective serodiagnostic tool for screening and typing of hantavirus infection in humans." 01/01/2014 - "Detection of Puumala hantavirus antigen in human intestine during acute hantavirus infection." 10/01/2013 - "Intriguingly, human DCs acquired the capacity to cross-present antigen upon hantavirus infection. "
8.	Indicators and Reagents (Reagents)IBA 09/01/2012 - "Antigenic diversity among different hantaviruses requires a variety of reagents for diagnosis of hantavirus infection. " 10/01/2003 - "The purpose of this study was to identify the optimal secondary antibodies or reagents for specific serodiagnosis of hantavirus infection in various rodent species. " 09/01/2012 - "To develop a diagnostic method applicable to various hantavirus infections with a single set of reagents, we developed an enzyme-linked immunosorbent assay (ELISA) using recombinant nucleocapsid proteins of three hantaviruses, Amur, Hokkaido, and Sin Nombre viruses. "
9.	Monoclonal AntibodiesIBA 01/01/2005 - "In order to study if passive immunization could inhibit hantavirus infection and/or symptoms, we inoculated two cynomolgus macaques with neutralizing monoclonal antibodies and subsequently challenged them with wild-type Puumala virus (PUUV), recently shown to induce typical signs of milder HFRS in cynomolgus macaques. " 12/01/2009 - "To improve the detection of hantavirus infection, we developed monoclonal antibodies (Mabs) against the nucleoprotein (rNDelta85) of the Araucaria hantavirus strain (ARAUV). "
10.	Transcription Factors (Transcription Factor)IBA 09/01/2013 - "Using human umbilical vein endothelial cells (HUVECs), this study investigates the molecular finger-print of nuclear transcription factors during hantavirus infection. " 09/01/2013 - "Death-domain associated protein-6 (DAXX) mediated apoptosis in hantavirus infection is counter-balanced by activation of interferon-stimulated nuclear transcription factors."

Therapies and Procedures

1.	Quantum Dots (Quantum Dot) 12/01/2011 - "[A study of immunoassay by using quantum dots to detect Hantavirus infection]."
2.	Blood Component Removal (Apheresis) 07/01/1995 - "Clinical studies are currently being performed in asthma, postoperative pain, anaphlyactoid reactions during low density lipoprotein apheresis, systemic inflammatory response syndrome, and suspected sepsis, head injury, and hantavirus infections to investigate the utility of kinin antagonists as therapeutic agents."
3.	Renal Dialysis (Hemodialysis) 08/01/1994 - "Management of hantavirus infections may require bed-rest, sedation, circulatory and ventilatory support and renal dialysis. " 05/01/2005 - "Acute sin nombre hantavirus infection complicated by renal failure requiring hemodialysis." 02/01/2010 - "Although hantaviruses are known to cause primarily acute renal damage (interstitial nephritis) in Eurasia, chronic effects of hantavirus infection and the detection of specific antibodies in hemodialysis patients have also been reported. "
4.	Transplants (Transplant) 09/01/2007 - "We describe the case of a 44-year-old kidney transplant recipient with acute renal transplant failure associated with acute hantavirus infection."
5.	Transplantation (Transplant Recipients) 09/01/2007 - "We describe the case of a 44-year-old kidney transplant recipient with acute renal transplant failure associated with acute hantavirus infection." 09/01/2007 - "In contrast to the mostly benign or even asymptomatic course of hantavirus infections in previously healthy individuals, the acute hantavirus infection in kidney transplant recipients represents an exceptional situation regarding diagnosis and therapy. "