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Multiple Chemical Sensitivity (Idiopathic Environmental Intolerance)

An acquired disorder characterized by recurrent symptoms, referable to multiple organ systems, occurring in response to demonstrable exposure to many chemically unrelated compounds at doses below those established in the general population to cause harmful effects. (Cullen MR. The worker with multiple chemical sensitivities: an overview. Occup Med 1987;2(4):655-61)
Also Known As:
Idiopathic Environmental Intolerance; Chemical Sensitivities, Multiple; Chemical Sensitivity, Multiple; Multiple Chemical Sensitivities; Multiple Chemical Sensitivity Syndrome; Sensitivities, Multiple Chemical; Sensitivity, Multiple Chemical; Environmental Intolerance, Idiopathic; Environmental Intolerances, Idiopathic; Intolerance, Idiopathic Environmental; Intolerances, Idiopathic Environmental; Idiopathic Environmental Intolerances
Networked: 131 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)
2. Fibromyalgia (Fibrositis)
3. Hypertension (High Blood Pressure)
4. Heart Failure
5. Genetic Predisposition to Disease (Genetic Predisposition)

Experts

1. Caccamo, Daniela: 6 articles (12/2021 - 01/2013)
2. De Luca, Chiara: 6 articles (12/2021 - 11/2010)
3. Pall, Martin L: 6 articles (09/2010 - 09/2002)
4. Currò, Monica: 4 articles (12/2021 - 01/2013)
5. Ientile, Riccardo: 4 articles (12/2021 - 01/2013)
6. van Thriel, Christoph: 4 articles (02/2020 - 02/2002)
7. Raskovic, Desanka: 4 articles (01/2015 - 11/2010)
8. Kunugita, Naoki: 4 articles (01/2007 - 06/2003)
9. Korkina, Liudmila: 3 articles (12/2021 - 01/2011)
10. Alessandrini, Marco: 3 articles (10/2021 - 04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Chemical Sensitivity:
1. CitalopramFDA LinkGeneric
2. SolventsIBA
3. Formaldehyde (Formol)FDA Link
4. Gasoline (Diesel Fuel)IBA
05/01/1998 - "The cohort was unique in several ways: (a) contact with gasoline was made by the workers at a time when no one had complained of multiple chemical sensitivities syndrome; (b) all were males of low socioeconomic status; (c) the exposure was well documented; (d) the cohort could be considered "naive" because, at the time of the study, the men were not members of support groups and were not being seen by clinical ecologists, and they were not labeled, either by self or others, as having multiple chemical sensitivities syndrome or any related diagnosis; and (e) at the time of interview, all workers we contacted appeared to be either gainfully employed or laid off temporarily and seeking gainful employment. "
07/01/1999 - "Re: Davidoff et al. Development of multiple chemical sensitivities in laborers after acute gasoline fume exposure in an underground tunnelling operation."
05/01/1998 - "Development of multiple chemical sensitivities in laborers after acute gasoline fume exposure in an underground tunneling operation."
05/01/1998 - "The workers were chronically overexposed to gasoline fumes, after which approximately one-fourth (26.7%) of our random sample of relatively naive, low-socioeconomic-status male laborers-although neither disabled nor generally litigious-reported the new onset of chemical hypersensitivities and other characteristics that fit conservative criteria for multiple chemical sensitivities syndrome."
03/01/2001 - "Sensitive subgroups include subjects who met Cullen's 1987 criteria for multiple chemical sensitivity (MCS), Gulf War veterans with chronic fatigue syndrome and chemical sensitivity (CFS/CS), and subjects with specific self-reported sensitivities to methyl terbutyl ether (MTBE) in gasoline (MTBE-sensitive). "
5. Caffeine (No Doz)FDA LinkGeneric
6. tyramine-deoxysorbitolIBA
7. Indicators and Reagents (Reagents)IBA
8. Immunologic Factors (Immunomodulators)IBA
9. Biomarkers (Surrogate Marker)IBA
10. Volatile Organic CompoundsIBA

Therapies and Procedures

1. Therapeutics
2. Transcranial Magnetic Stimulation
3. Steam Bath (Sauna)
4. Hypnosis (Mesmerism)
5. Anesthesia and Analgesia