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GABA Agonists (GABA Receptor Agonists)

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Endogenous compounds and drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).

Also Known As:

GABA Receptor Agonists; GABA Agonist; GABA Receptor Agonist; gamma-Aminobutyric Acid Agonist; Acid Agonist, gamma-Aminobutyric; Acid Agonists, gamma-Aminobutyric; Agonist, GABA; Agonist, GABA Receptor; Agonist, gamma-Aminobutyric Acid; Agonists, GABA; Agonists, GABA Receptor; Agonists, gamma-Aminobutyric Acid; Receptor Agonist, GABA; Receptor Agonists, GABA; gamma Aminobutyric Acid Agonist; gamma Aminobutyric Acid Agonists; gamma-Aminobutyric Acid Agonists

Networked: 269 relevant articles (19 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Molecular Mechanisms of Pharmacological Action: 7
    - Neurotransmitter Agents: 7915
      - GABA Agents: 47
        GABA Agonists: 269
        GABA-B Receptor Agonists: 110
        GABA-A Receptor Agonists: 88
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 7915
      - GABA Agents: 47
        GABA Agonists: 269
        GABA-B Receptor Agonists: 110
        GABA-A Receptor Agonists: 88

Experts

1.	Parent, Marise B: 3 articles (06/2009 - 05/2003)
2.	McCarson, Kenneth E: 2 articles (10/2014 - 01/2006)
3.	Enna, S J: 2 articles (10/2014 - 01/2006)
4.	Liu, Jia: 2 articles (01/2014 - 01/2013)
5.	Wang, Lu-Ning: 2 articles (01/2014 - 01/2013)
6.	Warburton, Elizabeth: 2 articles (01/2011 - 01/2008)
7.	Morris, Rhiannon S: 2 articles (01/2011 - 01/2008)
8.	Alawneh, Josef A: 2 articles (01/2011 - 01/2008)
9.	Clatworthy, Philip L: 2 articles (01/2011 - 01/2008)
10.	Cubeddu, Alessandra: 2 articles (09/2009 - 07/2009)

Related Diseases

1.	Movement Disorders (Movement Disorder) 01/01/2011 - "For the outcome of 'no clinically important improvement in tardive dyskinesia' GABA agonist drugs were not clearly better than placebo (n = 108, 3 RCTs, RR 0.83 CI 0.6 to 1.1). " 01/01/2004 - "For the outcome of 'no clinically important improvement in tardive dyskinesia' GABA agonist drugs were not clearly better than placebo (n = 108, RR 0.83 CI 0.6 to 1.1). " 01/01/2001 - "For the outcome of 'no clinically important improvement in tardive dyskinesia' GABA agonist drugs were not clearly better than placebo (n=108, RR 0.83 CI 0.6 to 1.1). " 01/01/2011 - "Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia." 01/01/2004 - "Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia."
2.	Seizures (Seizure) 02/09/2006 - "Therefore, the present study was performed to investigate whether seizure activity or GABA receptor agonist treatment changes KCC expression in the gerbil hippocampus. " 01/01/2013 - "Here, we review the use of current GABA agonist therapies for neonatal seizures and suggest other treatment strategies given recent developments in the understanding of disease pathogenesis. " 10/01/2009 - "Proconvulsant effects of GABA agonists on spontaneous neuronal activity and seizure like activity were never observed. " 11/01/1993 - "Both GABA agonists produced significant reductions in myoclonic, clonic, and tonic seizure thresholds. " 11/01/1993 - "Role of the fastigial nucleus in generalized seizures as demonstrated by GABA agonist microinjections."
3.	Pain (Aches) 01/01/2006 - "The discovery that GABA receptor agonists display antinociceptive properties in a variety of animal models of pain has provided an impetus for developing such agents for this purpose. " 05/15/2012 - "The current study evaluated the antinociceptive effects of lumbar intrathecal (i.t.) administration of GABA receptor agonists and NMDA receptor antagonists alone and in combination in rats with neuropathic SCI pain. " 05/31/2010 - "The current study evaluated the effects of the opioids and GABA agonists and antagonists in the RVM on an affective-motivational pain model. " 10/01/2000 - "Prevention of perpetuation of a somatosensory pain memory might also be possible through pharmacological agents such as N-methyl-D-aspartate antagonists and gamma-aminobutyric acid agonists, substances that have been shown to influence and prevent cortical reorganization." 08/01/1999 - "Those results suggest a clinical relevance of the coadministration of mu-opioids and GABA receptor agonists for pain control. "
4.	Schizophrenia (Dementia Praecox) 12/01/2003 - "In several clinical studies, the use of adjunctive GABA agonists was associated with greater improvement in core schizophrenia symptoms. " 01/01/2000 - "The inclusion criteria for all relevant randomised studies were that they should focus on people with schizophrenia or other chronic mental illnesses, with neuroleptic-induced TD and compare the use of GABA agonist drugs to placebo or no intervention. " 01/01/2011 - "We included reports if they were controlled trials dealing with people with neuroleptic-induced TD and schizophrenia or other chronic mental illness who had been randomly allocated to either non-benzodiazepine GABA agonist drugs with placebo or no intervention. " 01/01/2004 - "Randomised controlled trials comparing use of non-benzodiazepine GABA agonist drugs with placebo or no intervention, involving people with schizophrenia or other chronic mental illnesses with signs of antipsychotic-induced TD. " 01/01/2001 - "The inclusion criteria for all relevant randomised studies were that they should focus on people with schizophrenia or other chronic mental illnesses, with neuroleptic-induced TD and compare the use of non-benzodiazepine GABA agonist drugs to placebo or no intervention. "
5.	Epilepsy (Aura) 11/01/1993 - "Comparative study of the anticonvulsant effect of gamma-aminobutyric acid agonists in the feline kindling model of epilepsy." 10/24/1983 - "The available experimental evidence suggests that in bilaterally synchronous spike and wave epilepsies, GABA agonists are either ineffective or pejorative." 01/01/1983 - "This suggests that GABA-agonists will be of potential use in epilepsy. " 01/01/1992 - "GABA agonists aggravate seizures in several mutants, ranging from the photosensitive baboon to the genetically epilepsy-prone rat. " 01/01/1983 - "Furthermore GABA agonists are active in animal models for dyskinesia, epilepsy and depression, amongst others. "

Related Drugs and Biologics

1.	Baclofen
2.	gamma-Aminobutyric Acid (GABA)
3.	Muscimol
4.	progabide (Gabrene)
5.	Benzodiazepines
6.	4,5,6,7- tetrahydroisoxazolo(5,4- c)pyridin- 3- ol (THIP)
7.	Bicuculline
8.	GABA Antagonists
9.	Glutamic Acid (Glutamate)
10.	Clonazepam (Rivotril)

Related Therapies and Procedures

1.	Ligation
2.	Catheters
3.	Injections
4.	Analgesia
5.	Investigational Therapies (Experimental Therapy)