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erbB-2 Receptor (Receptor, erbB 2)

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A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members.

Also Known As:

Receptor, erbB 2; Receptor, erbB-2; Oncogene Protein HER-2; Proto-Oncogene Proteins c-erbB-2; Receptors, erbB-2; p185(c-neu); HER 2 Proto Oncogene Protein; Oncogene Protein HER 2; Proto Oncogene Protein HER 2; Proto Oncogene Proteins c erbB 2; Proto-Oncogene Protein, HER-2; Proto-Oncogene Protein, erbB-2; Proto-Oncogene Protein, neu; Receptors, erbB 2; c erbB 2 Protein; erbB 2 Proto Oncogene Protein; erbB 2 Receptor Protein Tyrosine Kinase; erbB-2 Receptors; neu Proto Oncogene Protein; HER-2 Proto-Oncogene Protein; Proto-Oncogene Protein HER-2; Proto-Oncogene Protein p185(neu); Receptor, neu; c-erbB-2 Protein; erbB-2 Proto-Oncogene Protein; erbB-2 Receptor Protein-Tyrosine Kinase; neu Proto-Oncogene Protein; neu Receptor

Networked: 459 relevant articles (7 outcomes, 58 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Kerin, Michael J: 4 articles (01/2014 - 01/2009)
2.	Miller, Nicola: 3 articles (01/2014 - 01/2009)
3.	Lowery, Aoife J: 3 articles (06/2012 - 01/2009)
4.	Ooi, Akishi: 3 articles (07/2002 - 01/2002)
5.	Tsuda, H: 3 articles (01/2001 - 01/2000)
6.	Fukutomi, T: 3 articles (01/2001 - 01/2000)
7.	Nanni, Patrizia: 2 articles (01/2014 - 11/2010)
8.	Cavallo, Federica: 2 articles (01/2014 - 06/2006)
9.	Ball, Graham: 2 articles (01/2014 - 01/2009)
10.	Errihani, Hassan: 2 articles (01/2014 - 01/2011)

Related Diseases

1.	Carcinoma (Carcinomatosis) 03/01/2008 - "The expression of the HER2/neu receptor is related to a reduction of the disease-free interval and global survival in patients with infiltrating ductal breast carcinoma locally advanced, confirming, in this work, to be a good prognostic factor." 11/01/2010 - "The prevention of mammary carcinoma by immunological strategies targeting the HER-2/neu receptor has proved to be effective in preclinical models. " 06/01/2000 - "Consequently, the purpose of this study was to assay the c-erbB-2 protein in the saliva and serum of women with and without carcinoma of the breast and to determine whether the protein possesses any diagnostic value. " 01/01/1994 - "c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma--an immunocytochemical study." 01/01/1993 - "[Immunohistochemical study of the c-erbB-2 protein in human gastric carcinoma]."
2.	Breast Neoplasms (Breast Cancer) 06/01/2013 - "In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. " 01/01/2012 - "The objective of this study was to compare the salivary protein profiles from individuals diagnosed with breast cancer that were either HER2/neu receptor positive or negative. " 02/15/2011 - "The results of the study showed that the lead drug tested significantly inhibited the growth of HER2/neu-positive breast cancer cells in vitro and in vivo by enhanced apoptosis and inhibition of HER2/neu receptor signaling with suppression of Akt phosphorylation. " 09/01/2000 - "The present study was initiated to determine the prognostic significance of c-erbB-2 protein overexpression in early onset breast cancer. " 11/01/1996 - "In addition, this study demonstrated that the c-erbB-2 protein over-expression was an effective independent prognostic indicator in patients with breast cancer."
3.	Neoplasms (Cancer) 08/01/1992 - "Patients with tumors containing high amounts of the c-erbB-2 protein had a significantly shorter (P less than 0.001) disease-free interval and overall survival rate than did patients with low amounts. " 08/01/2011 - "The aim of the study was to evaluate the role of c-erbB-2 protein expression in various groups of astrocytic tumors. " 09/15/2005 - "In the present study, we demonstrate that a physical association between the extracellular domain of human HER2/neu receptor (ECDHER2) plus anti-HER2/neu IgG3-(IL-2) or anti-HER2/neu IgG3-(GM-CSF) was required to elicit the most effective anti-tumor immune response against a syngeneic tumor expressing rat HER2/neu. " 01/01/1998 - "Immunohistochemical studies of the tumor revealed overexpression of p53 protein, but not that of c-erbB-2 protein. " 07/01/1997 - "In the present study, we evaluated the expression of EGFR and c-erbB-2 protein in 33 astrocytic tumors with immunohistochemistry. "
4.	Adenocarcinoma 06/14/1995 - "The ErbB-2 receptor (ErbB-2R) is overproduced in a high percentage of adenocarcinomas arising in the breast, ovary, lung and stomach, when compared to normal cells. " 07/01/1994 - "p53 protein and c-erbB-2 protein (p185) expression in endometrial adenocarcinoma of endometrioid type. " 01/01/1994 - "Out of 40 adenocarcinomas, only 2 samples showed weak immunoreaction, while 38 samples were moderately or strongly positive for c-erbB-2 protein. " 01/01/1994 - "High c-erbB-2 protein level in colorectal adenocarcinomas correlates with clinical parameters." 01/01/1994 - "c-erbB-2 protein expression could be an important prognostic indicator in Barrett's adenocarcinoma."
5.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2000 - "The present study was undertaken to examine the significance of c-erbB-2 protein expression as a prognostic factor in colorectal cancer. " 11/01/1998 - "Immunohistochemical study of c-erbB-2 protein in colorectal cancer and the correlation with patient survival." 02/12/2002 - "In terms of prognosis, no association was seen between either c-erbB-2 protein expression or the presence of the Val allele and patient survival (P>0.05 in each case), suggesting that c-erbB-2 is not a prognostic marker in colorectal cancer." 01/01/2002 - "Overexpression of the c-erbB-2 protein (also called HER-2/neu) is observed in a variety of malignancies including colorectal cancer (CRC). " 01/01/2002 - "Overexpression of c-erbB-2 protein correlates with chromosomal gain at the c-erbB-2 locus and patient survival in advanced colorectal carcinomas."

Related Drugs and Biologics

1.	Epidermal Growth Factor Receptor (EGF Receptor)
2.	trastuzumab (Herceptin)
3.	Paraffin
4.	DNA (Deoxyribonucleic Acid)
5.	Protein-Tyrosine Kinases (Tyrosine Kinase)
6.	Formaldehyde (Formol)
7.	Estrogens (Estrogen)
8.	Progesterone Receptors (Progesterone Receptor)
9.	Hormones
10.	Progesterone

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Neoadjuvant Therapy
4.	Adjuvant Chemotherapy
5.	Gastrectomy