Cholinergic Agonists

11/01/1988 - "However, exposure of preparations showing electrical seizures to blockers of synaptic transmission or to cholinergic agonists abolished interictal spiking in all hippocampal fields but did not impede the initiation of ictal episodes in area CA1. "
05/01/2001 - "The efficacy of the cholinergic agonist pilocarpine to evoke generalized seizures in rats was examined over the 24-h photocycle. "
01/01/1991 - "In contrast, bilateral microinjection of BMI into the rat striatum confers protection against seizures induced by the cholinergic agonist pilocarpine (380 mg/kg, i.p.), with an ED50 of 94 fmol (range 45-195 fmol). "
03/01/1987 - "We used limbic seizures induced in rats by systemic injection of the cholinergic agonist pilocarpine (380 mg/kg; i.p.) to study the neuronal pathways within the basal ganglia that modulate seizure threshold. "
01/01/2010 - "The systemic administration of pilocarpine, a cholinergic agonist, increased dramatically the cortical discharges with five characteristic seizures patterns and concomitantly decreased the frequency and duration of absence crisis. "

04/01/2002 - "Ultimately, cholinergic agonists may prove useful in the treatment of Alzheimer's disease."
11/01/2006 - "In Alzheimer's disease, cholinergic agonists have shown modest clinical benefits on cognitive and behavioural symptoms. "
04/01/2002 - "Cholinergic agonists and the treatment of Alzheimer's disease."
04/01/1991 - "(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease."
08/01/1990 - "In patients with Alzheimer's disease (AD), greatly diminished REM sleep might be expected because of the cholinergic deficit in this disease and because cholinergic agonists stimulate REM sleep in humans and animals. "

04/01/2011 - "This study indicates that vagus nerve and cholinergic agonists activate the sympathetic noradrenergic splenic nerve to control systemic inflammation. "
07/15/2011 - "Likewise, vagus nerve and cholinergic agonists fail to control inflammation in splenectomized and nude animals. "
09/01/2009 - "Because cholinergic modalities, acting through vagus nerve- and/or alpha7nAChR-mediated mechanism, have been confirmed to suppress excessive inflammation during the I/R injury in kidney, liver, lung and intestine, therefore, we hypothesize that cholinergic agonists may also provide a protection for the myocardial I/R injury."
09/01/2009 - "Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation."
01/01/2008 - "The vagus nerve system has also been shown to suppress innate immune response through endogenous release and exogenous administration of cholinergic agonists, ameliorating inflammation and lethality in sepsis models."

01/01/2012 - "In vivo experiments using neonatal mice model of Pemphigus have demonstrated that cholinergic agonists reduce these lesions. "
01/01/2000 - "The antiacantholytic activity of cholinergic agonists suggests a novel avenue for the development of a nonhormonal treatment of pemphigus."
03/01/2004 - "Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists."
10/01/2000 - "Treatment of keratinocyte monolayers with anti-alpha9 antibody induced pemphigus-like acantholysis, which could be reversed either spontaneously or by using the cholinergic agonist carbachol. "
02/08/2008 - "Previous studies showed that activation of Src and protein kinase C are the earliest events in the PV IgG-induced intracellular phosphorylation cascades and that cholinergic agonists are effective for treating patients with pemphigus. "

03/01/2007 - "The paper presents aspects managed by dental professionals (use of cholinergic agonists and other saliva stimulants, prevention of hyposalivation-induced rampant caries, and use of saliva substitutes), as well as the role of the radiation oncologist in minimizing salivary gland damage (parotid-sparing RT; cytoprotectants). "
05/01/2014 - "This analysis indicated that cholinergic agonists were more effective in treating radiation-induced hyposalivation compared with salivary substitutes, hyperbaric oxygen, and acupuncture. "
01/01/2009 - "Pilocarpine is a cholinergic agonist that increases salivary flow rate and has been used to treat xerostomia. "
03/01/2006 - "Cholinergic agonists and cytoprotective agents, specifically amifostine, can address xerostomia. "
01/01/2002 - "Pilocarpine is a cholinergic agonist that increases salivary flow and has been used to treat xerostomia. "