Cholinergic Agonists

11/01/1988 - "However, exposure of preparations showing electrical seizures to blockers of synaptic transmission or to cholinergic agonists abolished interictal spiking in all hippocampal fields but did not impede the initiation of ictal episodes in area CA1. "
05/01/2001 - "The efficacy of the cholinergic agonist pilocarpine to evoke generalized seizures in rats was examined over the 24-h photocycle. "
01/01/1991 - "In contrast, bilateral microinjection of BMI into the rat striatum confers protection against seizures induced by the cholinergic agonist pilocarpine (380 mg/kg, i.p.), with an ED50 of 94 fmol (range 45-195 fmol). "
03/01/1987 - "We used limbic seizures induced in rats by systemic injection of the cholinergic agonist pilocarpine (380 mg/kg; i.p.) to study the neuronal pathways within the basal ganglia that modulate seizure threshold. "
01/01/2013 - "In vivo, 3-channel EEG measurements in freely behaving mice revealed that Slc10a4 null mice had frequent epileptiform spike-activity before treatment, and developed epileptic seizures, detected by EEG and accompanied by observable behavioral components, more rapidly after injection of the cholinergic agonist pilocarpine. "

04/01/2002 - "Ultimately, cholinergic agonists may prove useful in the treatment of Alzheimer's disease."
11/01/2006 - "In Alzheimer's disease, cholinergic agonists have shown modest clinical benefits on cognitive and behavioural symptoms. "
04/01/2002 - "Cholinergic agonists and the treatment of Alzheimer's disease."
08/01/1991 - "The relative failure of symptomatic therapeutic trials for Alzheimer's disease using non-selective cholinergic agonists brings about the need for longitudinal studies with parallel designs aimed at disease stabilization, using trophic substances or amyloid suppressors."
04/01/1987 - "In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effects on cognitive function. "

04/01/2011 - "This study indicates that vagus nerve and cholinergic agonists activate the sympathetic noradrenergic splenic nerve to control systemic inflammation. "
01/01/2021 - "In a variety of inflammatory diseases, the classic cholinergic anti-inflammatory pathway lately received a lot of attention as via this pathway cholinergic agonists can reduce inflammation. "
10/01/2020 - "We conclude that lacrimal gland MEC function is altered by inflammation because the functions regulated by cholinergic agonists, VIP, and purinergic receptors are decreased in TSP1-/- compared with WT mice."
06/01/2020 - "Clarification of the role of cholinergic agonists in modulation of inflammation and immune system reactions is progressively ongoing. "
07/15/2011 - "Likewise, vagus nerve and cholinergic agonists fail to control inflammation in splenectomized and nude animals. "

01/01/2012 - "In vivo experiments using neonatal mice model of Pemphigus have demonstrated that cholinergic agonists reduce these lesions. "
01/01/2000 - "The antiacantholytic activity of cholinergic agonists suggests a novel avenue for the development of a nonhormonal treatment of pemphigus."
03/01/2004 - "Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists."
10/01/2000 - "Treatment of keratinocyte monolayers with anti-alpha9 antibody induced pemphigus-like acantholysis, which could be reversed either spontaneously or by using the cholinergic agonist carbachol. "
02/08/2008 - "Previous studies showed that activation of Src and protein kinase C are the earliest events in the PV IgG-induced intracellular phosphorylation cascades and that cholinergic agonists are effective for treating patients with pemphigus. "

05/01/1990 - "Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B."
04/01/1991 - "(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease."
02/01/2005 - "Cholinergic deficits are thought to underlie the postural instability and cognitive impairment of PSP, but trials of cholinergic agonists and cholinesterase inhibitors have failed to show improvement in motor function, quality of life and cognitive impairment. "