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Interleukin-12 (IL 12)

A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Also Known As:
IL 12; Interleukin 12; IL12; Interleukin-12 p70; Cytotoxic Lymphocyte Maturation Factor; IL-12 p70; Interleukin 12 p70; Edodekin Alfa; IL-12; Natural Killer Cell Stimulatory Factor
Networked: 9226 relevant articles (749 outcomes, 1232 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Cemazar, Maja: 27 articles (02/2022 - 11/2009)
2. Sersa, Gregor: 27 articles (02/2022 - 11/2009)
3. Egilmez, Nejat K: 25 articles (10/2019 - 05/2002)
4. Li, Shulin: 23 articles (01/2022 - 09/2001)
5. Casanova, Jean-Laurent: 22 articles (08/2021 - 02/2002)
6. Smyth, Mark J: 22 articles (11/2019 - 02/2002)
7. Hunter, Christopher A: 21 articles (11/2019 - 04/2002)
8. Sher, Alan: 19 articles (01/2019 - 06/2002)
9. Akira, Shizuo: 18 articles (01/2017 - 01/2002)
10. Di Carlo, Emma: 17 articles (10/2010 - 07/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Infections
3. Psoriasis (Pustulosis Palmaris et Plantaris)
4. Neoplasm Metastasis (Metastasis)
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Cytokines
2. Interleukin-12 (IL 12)
3. Ustekinumab (CNTO 1275)
4. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5. Interleukin-2 (IL2)
6. Interleukin-23 (Interleukin 23)
7. Interleukin-10 (Interleukin 10)
8. Interleukins
9. Monoclonal Antibodies
10. Interferon-gamma (Interferon, gamma)

Related Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Biological Therapy
4. Drug Therapy (Chemotherapy)
5. Injections