ras Proteins

Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.

Also Known As:

Networked: 224 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kloog, Yoel: 6 articles (06/2008 - 01/2003)
2.	Downward, Julian: 5 articles (04/2015 - 12/2008)
3.	Der, Channing J: 4 articles (09/2014 - 04/2004)
4.	Prior, Ian A: 3 articles (01/2015 - 04/2012)
5.	Hancock, John F: 3 articles (06/2013 - 04/2012)
6.	Sasazuki, Takehiko: 3 articles (09/2012 - 02/2005)
7.	Shirasawa, Senji: 3 articles (09/2012 - 02/2005)
8.	Castellano, Esther: 3 articles (03/2011 - 01/2010)
9.	Shannon, Kevin: 3 articles (04/2008 - 02/2007)
10.	Adjei, Alex A: 3 articles (11/2005 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2006 - "This study investigated the effects of RIG1, and the mechanisms responsible for these effects, on the activation of Ras proteins in HtTA cervical cancer cells. " 02/26/2000 - "Ras proteins exert substantial control on cell proliferation and gene-transcription events, and prenylation inhibitors are now included in clinical trials for cancer. " 12/01/1997 - "The information gained from this study should be useful both for study of the complicated functions of ras proteins and clinical detection of ras oncogenes in human tumor cells." 12/20/1995 - "Previous studies have demonstrated that T-cell immunity against some forms of mutant Ras proteins could be elicited, and some effectiveness against tumors expressing activated Ras has been reported. " 08/15/1995 - "Although previous studies have shown that FT inhibitors can block the growth of tumor cells carrying mutant Ras proteins, it remained unclear how this class of inhibitors would affect tumor cells such as in NF1, whose malignant growth appears to be mediated by up-regulation of wild-type Ras activity. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2015 - "We find that in a panel of isogenic SW48 colorectal cancer cells, endogenous Ras proteins are highly abundant with ≥260,000 total Ras protein copies per cell and the rank order of isoform abundance is KRAS>NRAS≥HRAS. " 12/01/1995 - "Aims-To determine possible associations between p53 allelic deletion, c-Ki-ras mutational activation, immunohistochemical detection of p53 and ras proteins, various clinicopathological variables, and patient outcome in 168 Dukes' stage B colorectal carcinomas.Methods" 08/01/1989 - "Detection of ras gene alterations and ras proteins in colorectal cancer." 08/15/2014 - "Constitutive activation of Ras-proteins plays an important role in the development of aggressive colorectal carcinomas and several other types of cancer. " 08/21/1998 - "Western blots used to characterize ras protein patterns in the same cancer/normal pairs have demonstrated that N-ras protein is more highly expressed in colon tissues than H- or K-ras proteins and that N-ras overexpression occurs in almost 70% of colorectal cancers, with or without a concurrent change in electrophoretic mobility of N-ras protein. "
3.	Melanoma (Melanoma, Malignant) 02/01/2009 - "B-Raf and N-Ras proteins are often activated in melanoma, yet their roles in producing inherent survival signals are not fully understood. " 09/01/1996 - "The present paper describes mutational analysis by polymerase chain reaction-single-strand conformation polymorphism (PCR/SSCP) and nucleotide sequence analysis of the genes coding for the p15, p53 and N-ras proteins in 26 metastases from 25 melanoma patients. " 01/01/1995 - "Mutated RAS genes as well as increased expression of wild-type ras proteins are common features in human tumors including melanoma. " 11/23/1999 - "Besides oncogenic Ras, wild-type Ras gene products also play a key role in receptor tyrosine kinase growth factor signaling, known to be of importance in oncogenesis and tumor progression of a variety of human neoplasms, including malignant melanoma; therefore, it is reasonable to speculate that a pharmacological approach that curtails Ras activity may represent a sensible approach to inhibit melanoma growth. " 01/15/2013 - "In this study, we demonstrate that unlike oncogenic Ras proteins, which are primarily activated by mutations that eliminate GTPase activity, the activated melanoma RAC1(P29S) protein maintains intrinsic GTP hydrolysis and is spontaneously activated by substantially increased inherent GDP/GTP nucleotide exchange. "
4.	Colonic Neoplasms (Colon Cancer) 08/12/1993 - "Preliminary human studies show that some patients with colon cancer have existent antibody responses to p21ras protein, implying the possible existence of autochthonous T-cell immunity to mutated ras proteins in those patients. " 10/31/1997 - "One function of oncogenic c-Ki-Ras proteins in colon cancer progression may be to up-regulate CEA and thus to prevent the lateral adhesion of adjacent colon epithelial cells that normally form a monolayer in vivo." 10/01/1995 - "Antibody to ras proteins in patients with colon cancer."
5.	Noonan Syndrome (Female Pseudo-Turner Syndrome) 11/01/2007 - "We performed detailed biochemical and functional studies of three mutant K-Ras proteins (P34R, D153V, and F156L) found in individuals with Noonan syndrome and cardiofaciocutaneous syndrome. "

Related Drugs and Biologics

1.	GTP Phosphohydrolases (GTPases)
2.	Phosphotransferases (Kinase)
3.	Guanosine Triphosphate (GTP)
4.	Guanosine Diphosphate (GDP)
5.	Proteome
6.	Proto-Oncogene Proteins c-raf
7.	Cardiofaciocutaneous syndrome
8.	Proteins (Proteins, Gene)
9.	Farnesyltranstransferase (Farnesyltransferase)
10.	Transferases

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Therapeutics