Retroelements (Retrotransposon)

Elements that are transcribed into RNA, reverse-transcribed into DNA and then inserted into a new site in the genome. Long terminal repeats (LTRs) similar to those from retroviruses are contained in retrotransposons and retrovirus-like elements. Retroposons, such as LONG INTERSPERSED NUCLEOTIDE ELEMENTS and SHORT INTERSPERSED NUCLEOTIDE ELEMENTS do not contain LTRs.

Also Known As:

Networked: 393 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schulz, Wolfgang A: 9 articles (01/2015 - 01/2005)
2.	Rangasamy, Danny: 6 articles (06/2014 - 01/2009)
3.	Spadafora, Corrado: 5 articles (09/2014 - 01/2006)
4.	Wabl, Matthias: 4 articles (09/2014 - 12/2009)
5.	Lee, Sung-Hun: 4 articles (01/2014 - 01/2009)
6.	Florl, Andrea R: 4 articles (01/2007 - 01/2005)
7.	Müller, Mirko: 4 articles (01/2007 - 01/2005)
8.	Belancio, Victoria P: 3 articles (06/2015 - 08/2010)
9.	Hoffmann, Michèle J: 3 articles (01/2015 - 11/2006)
10.	Sciamanna, Ilaria: 3 articles (09/2014 - 11/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "This mini-review aims to give a brief overview of the relationship that transposons and retrotransposons may have in the genetic cause of human cancer onset, or conversely creating protection against cancer. " 07/01/2015 - "The involvement of SAMHD1 in biological processes as varied as viral restriction, endogenous retroelement control, cancer, and modulation of anticancer/antiviral nucleoside drug efficacy makes it a valuable target for the development of small-molecule inhibitors. " 12/01/2014 - "Retrotransposon-based profiling of mammalian epigenomes: DNA methylation of IAP LTRs in embryonic stem, somatic and cancer cells." 07/01/2014 - "The results of this large-scale, comprehensive analysis of retrotransposon movement across tumor types suggest that somatic retrotransposon insertions may represent an important class of structural variation in cancer. " 07/01/2014 - "Finally, we developed TranspoSeq-Exome to interrogate an additional 767 tumor samples with hybrid-capture exome data and discovered 35 novel somatic retrotransposon insertions into exonic regions, including an insertion into an exon of the PTEN tumor suppressor gene. "
2.	Inflammation 01/01/2013 - "Being cell senescence, somatic DNA damage and inflammation three supposed key processes in human aging, and observing that several intracellular mechanisms normally controlling the activation of retroelements show a tendency to fade at late ages, a possible role of endogenous retroelements in organismal senescence is taken in consideration. " 09/01/2014 - "Therefore, plasmacytoma formation might occur, in part, by de novo insertion of these retroelements, induced or helped by the inflammation. " 09/01/2007 - "These results suggest that a basal level of endogenous retroelement activity exists in normal skin and that keratinocyte hyperproliferation and/or inflammation observed in psoriasis promote this activity. "
3.	Plasmacytoma 09/01/2014 - "The high frequency of de novo integrations into cancer genes suggests that endogenous retroelements are coresponsible for plasmacytoma formation and progression in BALB/c mice." 09/01/2014 - "Therefore, plasmacytoma formation might occur, in part, by de novo insertion of these retroelements, induced or helped by the inflammation. " 09/01/2014 - "We determined that mineral oil-induced plasmacytomas produce large amounts of endogenous retroelements--ecotropic and polytropic murine leukemia virus and intracisternal A particles. "
4.	Genomic Instability 12/01/2015 - "However, limited efforts have been made to study its DNA methylation, genomic instability, and long terminal repeat (LTR) retrotransposon polymorphism causing properties in different crops. " 12/01/2015 - "Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays." 10/01/2015 - "Retrotransposon expression or mobility is increased with age in multiple species and could promote genome instability or altered gene expression during aging. " 04/01/2015 - "Identification of nuclear pore, DNA replication, transcription, and repair host factors that affect retrotransposition has provided insights into how hosts and retrotransposons interact to balance genome stability and plasticity. " 05/01/2014 - "Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. "
5.	Aneuploidy (Aneuploid) 08/01/1993 - "As part of a study to identify dosage-sensitive modifiers of the white eye colour locus and the retrotransposon, copia, a segmental aneuploid screen was conducted. " 01/01/2015 - "In this study, a comparative analysis of the methylation index of LINE-1 retrotransposon, which is largely reflecting the methylation profile of the genome, is performed in placental tissues of spontaneous abortions with complete and mosaic forms of aneuploidy, and with a normal karyotype, as well as in the control group of induced abortions of the first trimester of pregnancy. " 04/01/2013 - "However, the identification of neural cells containing somatically generated mosaic aneuploidy - loss and/or gain of chromosomes from a euploid complement - and other genomic variations including LINE1 retrotransposons and regional patterns of DNA content variation (DCV), demonstrate that the brain is genomically heterogeneous. "

Related Drugs and Biologics

1.	Cytidine
2.	Biological Markers (Surrogate Marker)
3.	Cytosine
4.	Uracil
5.	Melatonin
6.	Glycine (Aminoacetic Acid)
7.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
8.	DNA (Deoxyribonucleic Acid)
9.	Retroelements (Retrotransposon)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Induced Abortion (Induced Abortions)