Cryptogenic Organizing Pneumonia (BOOP)

An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Also Known As:
BOOP; Cryptogenic Organizing Pneumonias; Organizing Pneumonia, Cryptogenic; Organizing Pneumonias, Cryptogenic; Pneumonia, Cryptogenic Organizing; Pneumonias, Cryptogenic Organizing; Bronchiolitis Obliterans Organizing Pneumonia
Networked: 375 relevant articles (23 outcomes, 20 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Cryptogenic Organizing Pneumonia (BOOP)
2. Crohn Disease (Crohn's Disease)
3. Pneumonia (Pneumonitis)
4. Sarcoidosis (Schaumann Disease)
5. Pulmonary Fibrosis (Hamman Rich Syndrome)


1. Lappi-Blanco, Elisa: 4 articles (05/2013 - 02/2002)
2. Müller, Nestor L: 4 articles (04/2006 - 07/2005)
3. Kohno, S: 4 articles (01/2003 - 09/2000)
4. Kadota, J: 4 articles (01/2003 - 09/2000)
5. Mukae, Hiroshi: 3 articles (05/2015 - 01/2008)
6. Kohno, Shigeru: 3 articles (05/2015 - 01/2008)
7. Sakamoto, Noriho: 3 articles (05/2015 - 01/2008)
8. Guzman, Josune: 3 articles (09/2013 - 02/2011)
9. Costabel, Ulrich: 3 articles (09/2013 - 02/2011)
10. Sarria, Rafael: 3 articles (09/2013 - 02/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cryptogenic Organizing Pneumonia:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
2. Prednisolone (Predate)FDA LinkGeneric
3. SteroidsIBA
4. Amiodarone (Amiodarona)FDA LinkGeneric
5. MethylprednisoloneFDA LinkGeneric
6. Cyclosporine (Ciclosporin)FDA LinkGeneric
7. Methotrexate (Mexate)FDA LinkGeneric
01/01/2001 - "Complete remission of BOOP was achieved by long-term treatment with low-dose methotrexate (5-20 mg/week, i.v.)."
01/01/2001 - "Successful treatment of bronchiolitis obliterans organizing pneumonia with low-dose methotrexate in a patient with Hodgkin's disease."
10/01/2001 - "Surgical lung biopsies disclosed nonspecific interstitial pneumonia (NSIP) in 18 of 22 patients (81.8%), organizing diffuse alveolar damage (DAD) in 2, bronchiolitis obliterans organizing pneumonia (BOOP) in 1, and usual interstitial pneumonia (UIP) in 1. Treatment usually included prednisone in 40-60 mg/d dosages for initial control, followed by lower dose prednisone plus an immunosuppressive agent such as azathioprine or methotrexate for disease suppression. "
03/01/2002 - "Studies evaluating (2) the use of serum eosinophilic cationic protein as a marker for development of subsequent persistent wheezing infants; (3) parental bronchial responsiveness as an indicator of genetic susceptibility to acute bronchiolitis; (4) prophylactic use of monoclonal antibody (Palivizumab) to control an outbreak of RSV in a hospital nursery; (5) a controlled clinical trial of ribaviron in acutely ill children; (6) reports of new associations with bronchiolitis obliterans organizing pneumonia (BOOP); (7) case reports of use of methotrexate as an alternate to corticosteroids in treatment of BOOP; (8) a newly described entity, eosinophilic bronchiolitis."
09/01/2000 - "BOOP, which is commonly caused by bleomycin and cyclophosphamide (as well as gold salts and methotrexate), appears on radiographs as hetero- and homogeneous peripheral opacities in both upper and lower lobes and on CT scans as poorly defined nodular consolidation, centrilobular nodules, and bronchial dilatation. "
8. Erythromycin (Erycette)FDA LinkGeneric
9. Prednisone (Sone)FDA LinkGeneric
10. FibrinIBA

Therapies and Procedures

1. Bone Marrow Transplantation (Transplantation, Bone Marrow)
2. Drug Therapy (Chemotherapy)
3. Transplants (Transplant)
4. Transplantation (Transplant Recipients)
5. Radiotherapy