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Cryptogenic Organizing Pneumonia

An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Also Known As:
Cryptogenic Organizing Pneumonias; Organizing Pneumonia, Cryptogenic; Organizing Pneumonia, Primary; Organizing Pneumonias, Primary; Pneumonia, Cryptogenic Organizing; Pneumonia, Primary Organizing; Primary Organizing Pneumonias; BOOP Bronchiolitis Obliterans Organizing Pneumonia; Bronchiolitis Obliterans Organizing Pneumonia; Primary Organizing Pneumonia
Networked: 346 relevant articles (16 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Crohn Disease (Crohn's Disease)
2. Pneumonia (Pneumonitis)
3. Organizing Pneumonia
4. Fibrosis (Cirrhosis)
5. Hemorrhage

Experts

1. Mukae, Hiroshi: 6 articles (04/2017 - 04/2007)
2. Kohno, Shigeru: 5 articles (05/2015 - 04/2007)
3. Suda, Takafumi: 4 articles (01/2022 - 10/2004)
4. Epler, Gary R: 4 articles (05/2020 - 03/2004)
5. Sakamoto, Noriho: 4 articles (05/2015 - 11/2008)
6. Kadota, J: 4 articles (12/2000 - 08/2000)
7. Kohno, S: 4 articles (12/2000 - 08/2000)
8. Chorostowska-Wynimko, Joanna: 3 articles (01/2017 - 01/2015)
9. Radzikowska, E: 3 articles (01/2016 - 12/2009)
10. Ishimatsu, Yuji: 3 articles (05/2015 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cryptogenic Organizing Pneumonia:
1. Adrenal Cortex Hormones (Corticosteroids)IBA
2. SteroidsIBA
3. Amiodarone (Amiodarona)FDA LinkGeneric
4. MacrolidesIBA
5. Erythromycin (Erycette)FDA LinkGeneric
6. Prednisolone (Predate)FDA LinkGeneric
7. Immunoglobulins (Immunoglobulin)IBA
8. Anti-Inflammatory Agents (Anti-Inflammatories)IBA
9. Triamcinolone (Aristocort)FDA Link
10. Proteins (Proteins, Gene)FDA Link
08/01/2001 - "In both patients, purified protein derivative and microbiologic testing excluded TB, and tissue examination yielded typical histologic changes of bronchiolitis obliterans organizing pneumonia (BOOP). "
05/01/2013 - "The aim of this study was to characterize the tight junction and adherens junction proteins in normal human lung, IPF, cryptogenic organizing pneumonia, and asbestosis. "
02/01/1995 - "Chronic eosinophilic pneumonia and idiopathic bronchiolitis obliterans organizing pneumonia: comparison of eosinophil number and degranulation by immunofluorescence staining for eosinophil-derived major basic protein."
01/01/2004 - "In this study we have studied the extent of reepithelialization of newly formed intraluminal connective tissue, the immunohistochemical expression and ultrastructural localization of the laminin-5 gamma2 chain protein, and the synthesis of the laminin-5 gamma2 chain mRNA in regenerating epithelial cells in cryptogenic organizing pneumonia (COP) and IPF. "
07/01/2016 - "Included in the calculation are cellular findings of the BAL, in addition the protein and albumin content of the BAL, the nicotine history (pack years), and spirometry (FEV1, IVC).Using linear discriminant analysis and creating classification trees, the relevance of the characteristics of 806 patients with ILK was examined (183 IPF, 191 cryptogenic organizing pneumonia, 147 lung involvement in autoimmune disease, 97 respiratory bronchiolitis interstitial lung disease, 118 extrinsic allergic alveolitis, 41 lymphocytic interstitial pneumonia (LIP), 23 non-specific interstitial pneumonia (NSIP), 88 controls).There was a close positive relationship between protein levels and lymphocytes in the group as a whole. "

Therapies and Procedures

1. Therapeutics
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)
3. Drug Therapy (Chemotherapy)
4. Segmental Mastectomy (Lumpectomy)
5. Radiotherapy