ATP-Binding Cassette Transporters (ABC Transporters)

A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.

Also Known As:

Networked: 676 relevant articles (15 outcomes, 63 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Zhe-Sheng: 16 articles (09/2015 - 11/2007)
2.	Bates, Susan E: 13 articles (01/2012 - 02/2002)
3.	Ambudkar, Suresh V: 12 articles (10/2013 - 11/2007)
4.	Robey, Robert W: 10 articles (01/2012 - 03/2006)
5.	Sugimoto, Yoshikazu: 9 articles (11/2015 - 01/2003)
6.	Scherrmann, Jean-Michel: 9 articles (11/2013 - 08/2006)
7.	Wink, Michael: 8 articles (02/2015 - 01/2010)
8.	Gottesman, Michael M: 8 articles (08/2011 - 08/2004)
9.	Lage, Hermann: 8 articles (12/2009 - 02/2002)
10.	Wang, Fang: 7 articles (12/2015 - 02/2011)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2013 - "Based on the knowledge of the structure, function, and distribution of MDR-related ABC transporters and the results of their preclinical and clinical evaluation, we discuss probable reasons why these inhibitors have not improved the outcome of therapy for cancer patients. " 01/15/2016 - "ABC transporters are known for driving drug efflux in many pathogens and cancer cells, therefore they are the subject of extensive studies. " 01/01/2013 - "This study investigated the expression and functions of these ABC transporters in endothelial cells in vitro and their potential contribution to cancer growth in mice. " 01/01/2013 - "Though the importance of ABC transporters for cancer cells is recognized, few studies have looked at its implications for the endothelial cells that are essential to tumor angiogenesis. " 03/01/2009 - "Inhibition of ABC-transporters by low-molecular weight compounds in cancer patients has been extensively investigated in clinical trials, but the results have been disappointing. "
2.	Alzheimer Disease (Alzheimer's Disease) 11/21/2012 - "Role of ABC transporters in the pathogenesis of Alzheimer's disease." 01/01/2012 - "ABC Transporters and the Alzheimer's Disease Enigma." 08/01/2008 - "Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease." 03/01/2008 - "Specific examples of novel treatment strategies for diseases, such as Alzheimer's disease and X-linked adrenoleukodystrophy that are based on modulation of ABC transporter function are discussed and we also examine possible functions for specific ABC transporters in human brain development." 01/01/2012 - "In addition to the known role of ABC transporters in proteopathies such as Parkinson's disease and Alzheimer's disease, our data highlight the importance of understanding the general function of ABC transporters for the brain's homeostasis and the regeneration potential."
3.	Breast Neoplasms (Breast Cancer) 10/01/2015 - "Many breast cancer cells acquire multidrug resistance (MDR) mediated by ABC transporters such as breast cancer resistance protein (BCRP/ABCG2). " 04/01/2012 - "Recent advances in pharmacogenomics of ABC transporters involved in breast cancer therapy." 01/01/2011 - "We provide possible explanations for why despite several decades of research, the precise role of ABC transporters in breast cancer MDR remains elusive." 04/15/2010 - "Liberated and cell-associated HA contributes to breast cancer initiation and progression, and therefore the inhibition of ABC transporters and consequently HA transport could provide therapeutic benefit in the treatment of breast cancer. " 07/01/2009 - "Two ATP-binding cassette transporters, multi-drug resistance-associated protein 2 and breast cancer resistance protein, are efflux transporters, expressed in various human tissues, and considered particularly important for intestinal drug absorption and hepatic drug elimination. "
4.	Carcinoma (Carcinomatosis) 04/01/2013 - "A major goal of our study was to investigate associations between the expression of ABC transporters and outcome of breast carcinoma patients. " 05/01/2010 - "Four of the examined ABC transporters are likely to play a role in the MDR of ovarian carcinoma. " 03/01/2008 - "The agents targeting the ABC transporters that are lowly expressed in both the carcinoma and normal tissues might serve as sensitivitive chemotherapeutics against NPC." 01/01/2003 - "Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines." 12/01/2011 - "ABCG2 is one of at least three so-called multidrug resistant ABC transporters expressed in humans, and its activity is associated with decreased efficacy of anti-cancer agents in several carcinomas. "
5.	Adenocarcinoma 05/01/2008 - "The aim of this study was to investigate the expression of ABC transporters in hepatoid adenocarcinomas. " 05/01/2013 - "Differences in transcript levels of ABC transporters between pancreatic adenocarcinoma and nonneoplastic tissues." 05/01/2008 - "These results support the hypothesis that ABC transporters participate in the mechanisms of multidrug resistance in hepatoid adenocarcinomas." 01/01/2002 - "[Functional activity of ABC transporters (markers of multidrug resistance) in human colon adenocarcinoma and normal colonic mucosa]." 05/01/2013 - "The aim of this study was to evaluate transcript levels of all 49 human ATP-binding cassette transporters (ABCs) in one of the most drug-resistant cancers, namely, the pancreatic ductal adenocarcinoma (PDAC). "

Related Drugs and Biologics

1.	P-Glycoprotein
2.	Adenosine Triphosphate (ATP)
3.	Enzymes
4.	Proteins (Proteins, Gene)
5.	Scavenger Receptors (Scavenger Receptor)
6.	Paclitaxel (Taxol)
7.	Peptides
8.	Curcumin
9.	Apolipoprotein A-I (Apolipoprotein A1)
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Therapeutics