Right Ventricular Dysfunction

A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.

Also Known As:

Networked: 491 relevant articles (19 outcomes, 41 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pulmonary Embolism
2.	Pulmonary Hypertension (Ayerza Syndrome)
3.	Shock
4.	Septic Shock (Toxic Shock Syndrome)
5.	Sepsis (Septicemia)

Experts

1.	Pruszczyk, Piotr: 8 articles (06/2014 - 06/2005)
2.	Goldhaber, Samuel Z: 7 articles (10/2015 - 03/2002)
3.	Lankeit, Mareike: 6 articles (09/2014 - 05/2008)
4.	Konstantinides, Stavros: 6 articles (09/2014 - 09/2005)
5.	Kostrubiec, Maciej: 6 articles (06/2014 - 07/2007)
6.	Henzler, Thomas: 4 articles (12/2015 - 01/2011)
7.	Schoenberg, Stefan O: 4 articles (12/2015 - 11/2012)
8.	Jiménez, David: 4 articles (04/2015 - 12/2010)
9.	Hetzer, Roland: 4 articles (01/2012 - 09/2003)
10.	Meyer, Mathias: 3 articles (12/2015 - 11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Right Ventricular Dysfunction:

1.	Idiopathic pulmonary hypertensionIBA 06/01/2015 - "What does the time constant of the pulmonary circulation tell us about the progression of right ventricular dysfunction in pulmonary arterial hypertension?" 04/01/2015 - "If the defect remains untreated, however, the rates of exercise intolerance, supraventricular arrhythmias, right ventricular dysfunction and pulmonary arterial hypertension (PAH) increase with patient age, and life expectancy is reduced. " 09/01/2014 - "Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction." 06/01/2014 - "Pulmonary arterial hypertension (PAH) is associated with aberrant pulmonary vascular remodeling that leads to increased pulmonary artery pressure, pulmonary vascular resistance, and right ventricular dysfunction. " 12/06/2011 - "Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy."
2.	Fibrinolytic Agents (Antithrombotic Agents)IBA 12/01/2002 - "Recent studies suggest the use of thrombolytic drugs in patients with normal systemic blood pressure who show right ventricular dysfunction at echocardiographic examination. " 09/01/2008 - "Current evidence does not support the use of thrombolytic agents in most hemodynamically stable patients with right ventricular dysfunction. " 12/01/1999 - "Recent reports have suggested that thrombolytic agents could be clinically useful in a subgroup who have right ventricular dysfunction on echocardiography. " 05/01/1994 - "The use of thrombolytic agents has decreased the incidence of right ventricular dysfunction after acute myocardial infarction. " 09/01/2001 - "The indications for the use of thrombolytic agents in massive pulmonary embolism (MPE) remain controversial and it has been suggested that transthoracic echocardiographic (TTE) examination, which is able to detect an associated right ventricular dysfunction, may cast light on this question. "
3.	sildenafil (Viagra)FDA Link 06/01/2013 - "The purpose of this study was to determine whether sildenafil improves 6-min walk distance (6MWD) in subjects with IPF and right ventricular dysfunction. " 07/01/2008 - "Role of sildenafil in acute posttransplant right ventricular dysfunction: successful experience in 13 consecutive patients." 02/01/2014 - "The use of oral sildenafil for management of right ventricular dysfunction after pediatric heart transplantation." 05/01/2009 - "Role of oral sildenafil in the treatment of right ventricular dysfunction after heart transplantation." 02/01/2014 - "Oral sildenafil was associated with a significant improvement in right ventricular dysfunction and invasive hemodynamic measurements in pediatric heart transplant recipients with high PVRI early after transplant."
4.	Heparin (Liquaemin)FDA LinkGeneric 01/01/2014 - "We included prospective, randomized, and clinical trials in thrombolysis with heparin alone in adults who had evidence of right ventricular dysfunction and normotension. " 12/01/2000 - "If there is no right ventricular dysfunction a treatment with heparin is indicated. " 02/27/1993 - "Data from a non-randomised study have hinted that in patients with acute pulmonary embolism (PE), thrombolysis followed by heparin more rapidly reverses right-ventricular dysfunction and restores pulmonary tissue perfusion than does heparin alone. " 05/01/2004 - "The combined with antithrombotic therapy using heparin sodium, was successfully treated the patient from cardiogenic shock due to APE with right ventricular dysfunction after cesarean section." 10/01/2005 - "In normotensive patients with right ventricular dysfunction at echocardiography, who represent about 30% of PE patients, the debate regarding the optimal therapy is still open and further studies are required to document a clinically relevant improvement in the benefit-risk ratio of thrombolytic agents over heparin alone: young people, with a very low risk of bleeding and a concomitant reduction of cardiopulmonary reserve might be the best candidates to systemic thrombolysis. "
5.	Biological Markers (Surrogate Marker)IBA 01/01/2010 - "The aim of the present study was to evaluate biomarkers of right ventricular dysfunction (RVD) in order to predict a complicated clinical course and long-term respiratory complications in acute PE.We" 12/01/2012 - "Among the 409 (70%) patients with biomarkers or echocardiography, 210 (51%) had at least one positive test and 67 (16%) had positive biomarkers and right ventricular dysfunction. " 04/01/2012 - "The debate has recently focused right ventricular dysfunction detected by echocardiography or spiral computed tomography (CT) and cardiac biomarkers. " 01/01/2012 - "Several parameters have been proposed and investigated to identify low-risk PE: clinical prediction rules, imaging tests, and laboratory markers of right ventricular dysfunction or injury. " 12/01/2011 - "In this review the clinical parameters and biomarkers of myocardial injury and right ventricular dysfunction (RVD) that have been suggested to play an important role in the risk stratification of PE are described first. "
6.	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/15/2015 - "Inhaled nitric oxide (iNO) therapy as a selective pulmonary vasodilator in cardiac surgery has been one of the most significant pharmacological advances in managing pulmonary hemodynamics and life threatening right ventricular dysfunction and failure. " 08/01/2011 - "Used frequently for right ventricular dysfunction (RVD), the clinical benefit of inhaled nitric oxide (iNO) is still unclear. " 01/01/1998 - "[Value of nitric oxide (NO) in neonatal right ventricular dysfunction]." 11/04/1997 - "Nitric oxide inhalation in the treatment of right ventricular dysfunction following left ventricular assist device implantation." 10/01/2006 - "We report the use of inhaled nitric oxide in a patient with acute right-ventricular dysfunction after extrapleural pneumonectomy."
7.	simendan (Levosimendan)IBA 03/01/2007 - "In an experimental model of acute right ventricular dysfunction, levosimendan improved global hemodynamics and optimized right ventriculovascular coupling via a moderate increase in right ventricular contractility and a mild reduction of right ventricular afterload." 01/01/2014 - "Preoperative use of levosimendan in cardiac surgery patients is one of the most attractive therapeutic alternatives in subjects with left or right ventricular dysfunction. " 12/01/2013 - "Preoperative levosimendan for right ventricular dysfunction before heart valve replacement surgery." 01/01/2012 - "We investigated the effect of preoperative levosimendan treatment in LVAD patients with moderate right ventricular dysfunction and right ventricular dilatation. " 03/01/2007 - "Experimental data suggest that levosimendan has pulmonary vasodilatory properties which, in combination with its positive inotropic effects, would render it particularly attractive for the treatment of right ventricular dysfunction. "
8.	Norepinephrine (Noradrenaline)FDA LinkGeneric 06/01/1989 - "The data suggested that in this model of right ventricular dysfunction, norepinephrine consistently improved myocardial performance without provoking further vasoconstriction in either the pulmonary or renal circulations." 12/01/2013 - "Sensibility analyses were conducted after exclusion of patients with a low perfusion index, patients receiving norepinephrine, and patients with right ventricular dysfunction. " 03/01/2000 - "Hyperdynamic septic shock with decreased vascular resistance is treated with norepinephrine to restore mean arterial pressure and to improve right ventricular dysfunction induced by pulmonary hypertension." 01/01/1987 - "Volume expansion, dobutamine and noradrenaline for treatment of right ventricular dysfunction in porcine septic shock: a combined invasive and radionuclide study."
9.	OxygenIBA 09/01/2014 - "Patients with high hematocrit, lower oxygen saturation, right ventricular dysfunction, aortopulmonary collaterals, and high preoperative right ventricular outflow tract gradients have a prolonged postoperative course." 10/01/2006 - "Postoperative right ventricular dysfunction may be characterized by elevated right atrial pressure and decreased systemic oxygen saturation owing to right-to-left shunting at the atrial level. " 02/01/2000 - "Supplemental oxygen may also improve right ventricular dysfunction in patients with underlying right ventricular dysfunction. " 05/01/1985 - "100) throughout exercise and at maximal effort: this corresponds to a lower stroke volume secondary to the absence of physical activity during childhood and/or residual cardiac lesions; abnormal chronotropism: the test was stopped at a lower heart rate corresponding to a fall in oxygen uptake during exercise, or to an increase in the systolic ejection period probably due to right ventricular dysfunction or to the patient reaching maximal ventilation; decreased maximal ventilation capacity due to a lower tidal volume and a higher respiratory rate. " 05/01/1996 - "In conclusion, right ventricular dysfunction is common in obstructive sleep apnoea, but it is reversible with nasal continuous positive airway pressure treatment and appears to be related to nocturnal oxygen desaturation."
10.	Endothelin Receptors (Endothelin Receptor)IBA 09/01/2007 - "While long-term oxygen therapy in patients with COPD and cor pulmonale and for example the administration of endothelin receptor antagonists in patients with idiopathic pulmonary hypertension is beneficial, the therapeutic use of drugs effective for left-sided heart failure is very limited in patients with right ventricular dysfunction."

Therapies and Procedures

1.	Thrombolytic Therapy 03/01/2014 - "Both right-ventricular dysfunction and pulmonary artery systolic pressure were improved significantly following thrombolytic therapy from baseline (49 vs. 28 mmHg; P = 0.01; 95% confidence interval -13 to -56). " 11/01/1994 - "A recent study described a subset of hemodynamically stable patients with right-ventricular dysfunction who also might benefit from thrombolytic therapy." 12/01/2010 - "Though some evidence suggests that a subset of high-risk normotensive patients with PE may have a reasonable risk to benefit ratio for thrombolytic therapy, single markers of right ventricular dysfunction (e.g. " 04/01/2010 - "When PE is fatal, right ventricular failure usually occurs within the first few hours, so right ventricular dysfunction (RVD) should be diagnosed rapidly to identify patients who could benefit from fibrinolytic therapy. " 09/01/2009 - "With proper risk assessment selected patients with stable hemodynamics and right ventricular dysfunction may also benefit from fibrinolytic therapy. "
2.	Catheters 03/01/2014 - "Ultrasound-assisted catheter-directed thrombolysis is more effective in reversing right ventricular dysfunction and dilatation in comparison with anticoagulation alone in patients at intermediate risk. " 02/15/2014 - "Right ventricular dysfunction in chronic thromboembolic obstruction of the pulmonary artery: a pressure-volume study using the conductance catheter." 03/01/2011 - "Rotation of the arterial cannula may represent a simple means of resuscitating patients who have suffered right ventricular dysfunction that is unrelieved by other, conventional methods." 07/01/1986 - "Intraoperative right ventricular dysfunction detected with a right ventricular ejection fraction catheter." 02/01/2007 - "When major right ventricular dysfunction is found due to central massive PE, immediate performance of surgical or catheter-guided embolectomy or thrombolysis should be considered."
3.	Transplantation (Transplant Recipients) 06/01/2009 - "Approximately 10% to 20% of heart transplant recipients experience potentially life-threatening right ventricular dysfunction intraoperatively and early postoperatively due to an elevated pulmonary vascular resistance. " 06/01/2005 - "Choice of transplantation procedure should be made after thorough evaluation, taking the potential reversibility of right ventricular dysfunction after the operation into account (Figure 1). " 06/01/1995 - "Only the right lung could be incorporated into the cardiopulmonary circulation at transplantation, resulting in transient right ventricular dysfunction, which resolved with vasodilator therapy. " 07/01/1990 - "Radionuclide ventriculography performed early after transplantation can identify patients both with abnormal biventricular function resulting from preservation injury and with isolated right ventricular dysfunction. " 04/01/1990 - "The high prevalence of RBBB morphology in heart transplant recipients appears to be related to posterior rotation of the long axis of the heart in the transverse plane, probably resulting from the surgical technique, and to right ventricular dysfunction."
4.	Transplants (Transplant) 06/01/1995 - "Mechanisms of transplant right ventricular dysfunction." 10/06/2011 - "The impact of preoperative right ventricular dysfunction on early hemodynamic instability after coronary artery bypass graft surgery." 05/01/2010 - "The administration of iNO during these lung transplant procedures could decrease right ventricular dysfunction by reducing PVR and help to avoid the use of cardiopulmonary bypass." 09/01/2008 - "Early graft failure, particularly right ventricular dysfunction, remains a significant determinant of early morbidity and mortality in heart transplant recipients. " 04/01/2007 - "Haemodynamic compromise was evident with lateral positioning of greater than 60 degrees to the right side in patients requiring vasopressors and/or with right ventricular dysfunction; or with lateral positioning in postoperative coronary artery bypass graft patients. "
5.	Lung Transplantation 08/01/2013 - "Right-sided heart size and right ventricular dysfunction measured by echocardiography and higher pulmonary vascular resistance by invasive hemodynamic assessment predict mortality in patients with IPF evaluated for lung transplantation." 07/01/1992 - "Experience with single-lung transplantation for other conditions suggested that associated severe right ventricular dysfunction resulting from increased afterload would recover after placement of a satisfactory lung allograft. " 05/01/2006 - "Some lung transplantation (LT) recipients suffer from pulmonary hypertension and right ventricular dysfunction or failure requiring extracorporeal circulation (ECC) to avoid catastrophic complications during surgery. " 12/01/1991 - "In patients with moderate pulmonary hypertension and right ventricular dysfunction secondary to end stage fibrosing lung disease single lung transplantation was followed by an improvement in pulmonary haemodynamic variables and right ventricular function." 10/01/2011 - "Combining tricuspid valve repair with double lung transplantation in patients with severe pulmonary hypertension, tricuspid regurgitation, and right ventricular dysfunction."