Marginal Zone B-Cell Lymphoma (MALT Lymphoma)

Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.

Also Known As:

Networked: 968 relevant articles (80 outcomes, 82 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Lymphoma (Lymphomas)
3.	Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
4.	Infection
5.	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)

Experts

1.	Raderer, Markus: 33 articles (12/2015 - 09/2002)
2.	Yoshino, Tadashi: 19 articles (01/2015 - 04/2002)
3.	Chott, Andreas: 16 articles (06/2015 - 09/2002)
4.	Kiesewetter, Barbara: 13 articles (12/2015 - 12/2011)
5.	Du, Ming-Qing: 13 articles (05/2013 - 05/2002)
6.	Streubel, Berthold: 11 articles (05/2015 - 03/2003)
7.	Inagaki, Hiroshi: 11 articles (08/2013 - 04/2002)
8.	Ye, Hongtao: 11 articles (03/2010 - 05/2002)
9.	Nakamura, Shigeo: 11 articles (09/2009 - 02/2002)
10.	Müllauer, Leonhard: 10 articles (12/2015 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Marginal Zone B-Cell Lymphoma:

1.	rituximab (Mabthera)FDA Link 09/01/2010 - "This is the first case of rituximab treatment in a patient with SLE who developed lacrimal gland MALT lymphoma, resulting in complete durable remission." 01/01/2003 - "After reassessment of histological samples for the presence of MALT lymphoma, patients were evaluated as regards date of diagnosis, prior therapy for MALT lymphoma, sites of involvement upon treatment with rituximab, clinical response in terms of complete remission (CR), partial response (PR), stable disease (SD) and progressive disease as well as symptomatic response, duration of response and survival. " 01/01/2011 - "The 2 conjunctival MALT lymphoma patients achieved complete remission after intraconjunctival rituximab treatment, which shows that this method of administration can overcome the primary resistance to this monoclonal antibody. " 04/01/2006 - "pylori-negative gastric MALT lymphoma treated successfully with rituximab." 09/01/2005 - "This case report demonstrates the potential efficacy of rituximab as a single therapeutic agent in patients with pulmonary MALT lymphoma."
2.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/2010 - "Gastric MALT lymphomas harboring such translocations usually do not respond to Helicobacter pylori eradication, while most of those without translocation can be cured by antibiotics. " 12/01/2008 - "pylori) with antibiotics induces complete remission in 75% of patients with gastric MALT lymphoma. " 08/01/2014 - "We have performed a retrospective analysis of all patients with extragastric mucosa-associated lymphoid tissue (MALT) lymphoma treated at our institution to compare the efficacy of first-line therapeutic modalities including surgery, radiation, systemic therapy, and antibiotics. " 06/01/2013 - "Clinically, for Helicobacter pylori-positive low-grade MALT lymphoma, antibiotics have been used as the first-line treatment. " 12/01/1999 - "We report a rare case of nasal mucosal MALT lymphoma which responded to treatment with antibiotics and has since then remained in remission."
3.	CladribineFDA LinkGeneric 11/01/2006 - "Prolonged clinical remission in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type treated with cladribine: 6 year follow-up of a phase II trial." 09/15/2002 - "Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with cladribine: a phase II study." 01/01/2011 - "Surgery, radiation therapy, and/or administration of cladribine (2CdA) result in the best outcomes in treating MALT lymphomas with MALT1 disruption." 07/01/2004 - "T(11;18)-bearing pulmonary mucosa-associated lymphoid tissue lymphoma responding to cladribine." 11/01/2002 - "The patient received intravenous treatment with 0.12 mg/kg per day of 2-chlorodeoxyadenosine (2-CDA) over 5 days for management of MALT lymphoma, as it was resistant to eradication of Helicobacter pylori. "
4.	Chlorambucil (Leukeran)FDA Link 06/01/2004 - "Five patients with mucosa-associated lymphoid tissue (MALT) lymphoma (Helicobacter pylori negative) were initially treated with daily chlorambucil (Chl, 0.06-0.08 mg/kg per day) and achieved complete remission (n = 4) or partial remission (n = 1). " 02/01/2009 - "Chlorambucil versus observation after anti-Helicobacter therapy in gastric MALT lymphomas: results of the international randomised LY03 trial." 07/01/2009 - "No advantage for chlorambucil maintenance therapy in gastric MALT lymphoma." 07/01/2006 - "Medical records of all patients with histology-verified orbital MALT lymphoma treated with oral chlorambucil at the Royal Melbourne Hospital were reviewed. " 07/01/2006 - "To report the outcome of oral chlorambucil as a single treatment in patients with orbital mucosa-associated lymphoid tissue (MALT) lymphoma. "
5.	Doxycycline (Vibramycin)FDA LinkGeneric 04/01/2015 - "Long-term outcomes of first-line treatment with doxycycline in patients with previously untreated ocular adnexal marginal zone B cell lymphoma." 05/01/2010 - "This retrospective study was launched to evaluate the efficacy of doxycycline and to find independent predictors of a clinical response in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue (OAML). " 10/04/2006 - "Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial." 05/01/2010 - "First-line therapy with doxycycline in ocular adnexal mucosa-associated lymphoid tissue lymphoma: a retrospective analysis of clinical predictors." 08/01/2005 - "Nine patients with C psittaci-positive marginal-zone B-cell lymphoma of the ocular adnexa at diagnosis or relapse were treated with doxycycline 100 mg, bid orally, for 3 weeks. "
6.	Thalidomide (Thalomid)FDA Link 12/01/2011 - "This retrospective study evaluated the efficacy of thalidomide in standard therapy-failure gastric MALT lymphoma. " 12/01/2011 - "Thalidomide is an effective salvage treatment for standard therapy-failure, t(11;18)(q21;q21) translocation-negative gastric MALT lymphoma and deserves further exploration." 12/01/2011 - "t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement." 09/01/2005 - "Very good partial response in a patient with MALT-lymphoma of the lung after treatment with low-dose thalidomide." 08/01/2009 - "Absence of efficacy of thalidomide monotherapy in patients with extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma)."
7.	AntigensIBA 08/01/2004 - "The ability to manipulate experientially the presence of the bacterium in the animal model will allow further studies examining the role of antigen drive in the development of Helicobacter-associated MALT lymphoma." 01/21/2014 - "There are descriptions of MALT lymphomas affecting practically every organ and system, with a marked geographic variability partially attributable to the epidemiology of the underlying risk factors; nevertheless, the digestive system (and predominantly the stomach) is the most frequently involved location, reflecting the gastrointestinal tract's unique characteristics of contact with foreign antigens, high mucosal permeability, large extension and intrinsic lymphoid system. " 06/01/2012 - "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type (EMZL) is considered an antigen driven lymphoid malignancy associated with protracted antigenic stimulation by microbial pathogens, auto-antigens or other unknown stimuli, which trigger a sustained lymphoid proliferation at sites normally devoid of lymphoid tissue. " 06/01/2011 - "The development of MALT lymphoma temporarily depends on antigen stimulation of Helicobacter pylori. " 06/01/2010 - "In conclusion, our data suggest that B-cell receptor-derived signals cooperate with T-helper cell signals in driving the progression of MALT lymphoma, providing an explanation for the unique antigen dependence of this B-cell malignancy."
8.	Familial primary gastric lymphomaIBA 06/01/2015 - "Relatively little is known about the long-term outcome of patients with Helicobacter pylori (HP)-negative gastric lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with antibiotic therapy as sole management. " 02/01/2013 - "Twenty-one patients had gastric lymphoma, while 19 suffered from extragastric mucosa-associated lymphoid tissue lymphoma. " 07/01/2012 - "The most common gastric lymphoma was DLBCL (54.5%) followed by mucosa-associated lymphoid tissue (MALT) lymphoma (41%). " 11/15/2009 - "Twenty-two patients were studied, including 12 patients with gastric lymphoma and 10 patients with extragastric MALT lymphoma. " 01/01/2008 - "A computerized literature reach through Medline, Cancerlit and Embase were performed, applying the words: high grade gastric lymphoma, or diffuse large B cell, MALT gastric lymphoma, DLBCLL (MALT) lymphoma and Helicobacter. "
9.	Immunoglobulins (Immunoglobulin)IBA 09/01/2012 - "Three years later, she developed a second focus of extranodal marginal zone B-cell lymphoma on her left arm, but immunohistochemical studies demonstrated monotypic immunostaining of plasma cells for immunoglobulin kappa light chain confirmed after repeat analysis. " 09/01/2012 - "We present the case of a 37-year-old female who developed extranodal marginal zone B-cell lymphoma with immunohistochemical studies showing monotypic immunostaining of plasma cells for immunoglobulin lambda light chain on her right arm in 2008. " 07/20/2015 - "Immunoglobulin G4 Positive Mucosa-associated Lymphoid Tissue Lymphoma of the Lacrimal Gland." 05/01/2014 - "Close pathogenetic relationship between ocular immunoglobulin G4-related disease (IgG4-RD) and ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma." 02/01/2010 - "To our knowledge, this is the first case of thymic MALT lymphoma with marked accumulation of histiocytes with immunoglobulin inclusions in a patient with Sjögren's syndrome."
10.	Amyloid (Amyloid Fibrils)IBA 01/01/2014 - "We describe the unusual case of a patient with an adnexal mass secondary to MALT lymphoma with associated amyloid deposition. " 01/01/2014 - "We report two cases of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma with associated amyloid protein deposition. " 01/01/2014 - "Cytologic findings and differential diagnoses of primary thyroid MALT lymphoma with striking plasma cell differentiation and amyloid deposition." 04/01/2013 - "Lung biopsy demonstrated the presence of amyloid in all patients and was associated with mucosa-associated lymphoid tissue (MALT) lymphoma in three patients. " 01/01/2012 - "We describe the clinical and pathologic features of 20 cases of MALT lymphoma and associated amyloid deposition across diverse primary sites. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/2011 - "This is a unique case in that it represents relapse and dissemination of MALT lymphoma to a completely new site following a complete remission status post radiation and chemotherapy." 04/01/2001 - "Combined chemotherapy and radiation therapy for the intestinal MALT lymphoma produced complete remission that lasted for 2 years. " 08/01/2012 - "The aim of this study was to analyze the efficacy of first-line chemotherapy in treating patients with ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). " 08/01/2008 - "The purpose of this work was to study retrospectively the molecular response and outcome of 19 gastric mucosa associated lymphoid tissue (MALT) lymphoma patients achieving histological remission after chemotherapy or surgery. " 08/01/2012 - "[Efficacy of chemotherapy as a first-line treatment in patients with ocular adnexal MALT lymphoma]."
2.	Radiotherapy 09/01/2012 - "pylori eradication induces MALT lymphoma regression in most patients and tumoral recurrence in the long term is exceptional; radiotherapy is an excellent second-line option; a watch and wait approach to histologic recurrence after initial MALT lymphoma remission is a reasonable alternative. " 05/01/2012 - "Helicobacter pylori-Negative Primary Rectal MALT Lymphoma: Complete Remission after Radiotherapy." 08/01/2003 - "Localized MALT lymphomas of the orbit, conjunctiva, salivary glands, and thyroid gland are treated successfully with radiotherapy. " 05/01/2012 - "As such, we propose radiotherapy to be a safe and effective means for treating rectal MALT lymphoma." 09/01/2003 - "Radiotherapy seems a safe and effective treatment modality for low-grade MALT lymphoma of the ampulla of Vater."
3.	Gastrectomy 01/01/1992 - "The identification of these microscopic lesions may explain the development of local relapse, often after a long disease-free interval, in patients with gastric MALT lymphoma treated by partial gastrectomy where excision appears to have been complete. " 12/01/2002 - "Gastric irradiation is an effective and safe alternative to gastrectomy in the treatment of low-grade MALT lymphoma of the stomach with the added advantage of organ preservation." 01/01/1996 - "However, gastrectomy for gastric MALT lymphomas is not in favor because of the efficacy of antibiotic regimens that can eliminate H. " 11/01/2013 - "The patient was a man in his 60s and had a history of total gastrectomy with jejunal pouch ρ-interposition for mucosa-associated lymphoid tissue (MALT) lymphoma in 1994. " 07/01/2006 - "Laparoscopy-assisted total gastrectomy for a case of MALT lymphoma: a case report."
4.	Aftercare (After-Treatment) 09/01/2003 - "Thus, this method is very useful to assess not only the histological diagnosis of MALT lymphoma but also the effectiveness after treatment." 01/01/2012 - "Samples of 35 patients with gastric MALT lymphoma at diagnosis and after treatment were included. " 07/01/2011 - "We have reported the characteristics of magnified endoscopic images of gastric mucosa-associated lymphoid tissue (MALT) lymphoma before and after treatment. " 06/01/2010 - "We examined eight rectal MALT lymphomas treated with antibiotic treatments to determine whether they regressed after treatment. " 10/01/2008 - "The microstructural pattern, collecting venules, and abnormal vessels in gastric MALT lymphoma were assessed before treatment and at 4 to 7 months after treatment by using magnifying endoscopy. "
5.	Highly Active Antiretroviral Therapy (HAART) 01/01/2005 - "We describe here an original case of HIV(+) MALT lymphoma with bronchial, conjuctival and laryngeal involvement for which a clinical and histopathological remission has been obtained with HAART alone. " 01/01/2005 - "HIV+ MALT lymphoma remission induced by highly active antiretroviral therapy alone." 09/01/2001 - "Remission of a high-grade gastric mucosa associated lymphoid tissue (MALT) lymphoma following Helicobacter pylori eradication and highly active antiretroviral therapy in a patient with AIDS."