P-Glycoproteins

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Also Known As:

Networked: 190 relevant articles (6 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aleksunes, Lauren M: 4 articles (01/2013 - 09/2008)
2.	Vecht, Charles J: 4 articles (05/2010 - 05/2005)
3.	Masereeuw, Rosalinde: 3 articles (03/2014 - 12/2012)
4.	Liu, Shuang: 3 articles (01/2012 - 10/2008)
5.	Hagmann, Wolfgang: 3 articles (01/2010 - 11/2003)
6.	Pieters, R: 3 articles (07/2006 - 05/2002)
7.	Scheper, R J: 3 articles (05/2003 - 09/2000)
8.	van den Berg, E: 3 articles (05/2003 - 09/2000)
9.	Wang, Lijun: 2 articles (10/2015 - 10/2008)
10.	Nowicki, Michał: 2 articles (08/2015 - 08/2013)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2004 - "Relevance of multidrug resistance proteins on the clinical efficacy of cancer therapy." 07/01/2015 - "Multidrug Resistance Proteins (MRPs) and Cancer Therapy." 01/01/2014 - "The effect ofT-DM1 may also be compromised by multidrug resistance proteins that pump DM1 out of cancer cells. " 01/01/2013 - "Possible roles of the xenobiotic transporter P-glycoproteins encoded by the MDR1 3435 C>T gene polymorphism in differentiated thyroid cancers." 09/01/2011 - "Nine ABCC subfamily members, the so-called multidrug resistance proteins (MRPs) 1-9, have been implicated in mediating multidrug resistance in tumor cells to varying degrees as the efflux extrude chemotherapeutic compounds (or their metabolites) from malignant cells. "
2.	Seizures (Seizure) 11/01/2009 - "One of the candidate mechanisms of pharmacoresistance is the limitation of AED access to the seizure focus by overexpression of efflux transporters, including P-glycoprotein (Pgp) and multidrug resistance proteins (MRPs).In this respect, it is important to know which AEDs are substrates for such drug transporters in humans. " 05/01/2007 - "Multidrug-resistance proteins prevent the access of antiepileptic drugs into brain parenchyma, which partly explains why seizures are frequently refractory to treatment. " 05/01/2010 - "Future research on seizure management in brain tumor patients should focus on better insight into the influence of multidrug resistance proteins on anticonvulsant drug transport over the blood-brain barrier, efficacy of new anticonvulsants with no or few interactions with other drugs, synergistic combinations of anticonvulsants in order to limit toxicity and therapeutic drug monitoring of anticonvulsants in current clinical practice and in new drug studies, including the effects of concomitant administration of chemotherapeutic agents." 03/01/2008 - "Yet many herbs may increase the risk for seizures, through intrinsic proconvulsant properties or contamination by heavy metals, as well as via effects on the cytochrome P450 enzymes and P-glycoproteins, altering antiepileptic drug (AED) disposition. "
3.	Brain Neoplasms (Brain Tumor) 01/01/2010 - "Expression and clinical significance of multidrug resistance proteins in brain tumors." 06/01/2008 - "Genetic factors also play an important role and multidrug-resistance proteins associated with brain tumors can be a major cause of epilepsy refractoriness. " 05/01/2010 - "Future research on seizure management in brain tumor patients should focus on better insight into the influence of multidrug resistance proteins on anticonvulsant drug transport over the blood-brain barrier, efficacy of new anticonvulsants with no or few interactions with other drugs, synergistic combinations of anticonvulsants in order to limit toxicity and therapeutic drug monitoring of anticonvulsants in current clinical practice and in new drug studies, including the effects of concomitant administration of chemotherapeutic agents."
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/01/2009 - "Overexpression of multidrug resistance proteins (Mdrs) and enhanced antiapoptotic capability are two of the main mechanisms by which Bcr/Abl(+) chronic myeloid leukemia cells acquire drug resistance; however, it has been shown that Mdr-1 expression provides minimal protection against cell apoptosis induced by chemotherapeutic drugs. " 01/01/2009 - "imatinib, multidrug resistance proteins, chronic myeloid leukemia, PGP, MRP1, LRP."
5.	Breast Neoplasms (Breast Cancer) 01/01/2008 - "In this review a comprehensive assessment and annotation of recent findings in relation to genetic variation in the Multidrug Resistance Proteins 1-5 (ABCC1-5) and Breast Cancer Resistance Protein (ABCG2) are described, with particular emphasis on the impact of such transporter genetic variation to drug disposition or efficacy." 03/02/2004 - "Previously, we showed that multidrug resistance proteins MRP1 and MRP3 attenuate cytotoxic and transactivating activities of 15-d-PGJ(2) in MCF7 breast cancer cells. " 09/01/2013 - "The multidrug resistance proteins, P-glycoprotein (P-gp, encoded by the ABCB1 gene) and breast cancer resistance protein (BCRP, encoded by ABCG2) are highly expressed in the first trimester placenta. " 11/01/2011 - "The aim of this work was to investigate the possibility of BT being transported by P-glycoprotein (MDR1), multidrug resistance proteins (MRPs), or breast cancer resistance protein (BCRP). " 04/01/2011 - "Such transporters include P-glycoprotein (P-gp, gene symbol ABCB1), the breast cancer resistance protein (BCRP, gene symbol ABCG2), and the multidrug resistance proteins (MRPs, gene symbol ABCCs). "

Related Drugs and Biologics

1.	P-Glycoprotein
2.	Anticonvulsants (Antiepileptic Drugs)
3.	Paclitaxel (Taxol)
4.	flavopiridol
5.	Proteins (Proteins, Gene)
6.	Organic Anion Transporters
7.	Messenger RNA (mRNA)
8.	Cyclosporine (Ciclosporin)
9.	Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
10.	Valproic Acid (Valproate, Semisodium)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Adjuvant Chemotherapy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Investigational Therapies (Experimental Therapy)