Subfamily B ATP Binding Cassette Transporter

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Also Known As:

Networked: 258 relevant articles (8 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Masereeuw, Rosalinde: 4 articles (01/2020 - 12/2012)
2.	Aleksunes, Lauren M: 4 articles (09/2013 - 09/2008)
3.	Vecht, Charles J: 4 articles (05/2010 - 05/2005)
4.	Assaraf, Yehuda G: 3 articles (01/2021 - 08/2006)
5.	Chen, Zhe-Sheng: 3 articles (01/2021 - 09/2011)
6.	Liu, Shuang: 3 articles (01/2012 - 10/2008)
7.	Hagmann, Wolfgang: 3 articles (12/2010 - 11/2003)
8.	Scheper, R J: 3 articles (05/2003 - 09/2000)
9.	van den Berg, E: 3 articles (05/2003 - 09/2000)
10.	Järvinen, Erkka: 2 articles (01/2021 - 10/2017)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2016 - "This coupling of UGT and multidrug resistance proteins has been intensively studied, particularly in the case of antitumor treatment, when this resistance is "improved" by differences in UGT expression between tumor and healthy tissue. " 01/01/2019 - "Here, we report a study on the effect of a mix of natural extracts (MIX2) prepared from fresh fruits of Prunus spinosa, Crataegus monogyna, Sorbus aucuparia, and Euonymus europaeus on the classic hallmarks of cancer cells and the expression of multidrug resistance proteins. " 04/01/2000 - "The physiological function of P-glycoproteins is explored through studies of gene knockout models and expression patterns in normal tissues and tumors. " 01/01/2023 - "In this review, we also investigated the effect of AMPK on different cancer chemo-resistance mechanisms such as cancer stem cells, p-glycoproteins, OCT-4, NANOG, KLF4 and immune microenvironment." 01/01/2022 - "As the C subfamily in the ABC family, multidrug resistance proteins (MRPs/ABCCs) export a variety of antitumour drugs and are expressed in a variety of cancers. "
2.	Brain Neoplasms (Brain Tumor) 09/05/2010 - "Expression and clinical significance of multidrug resistance proteins in brain tumors." 06/01/2008 - "Genetic factors also play an important role and multidrug-resistance proteins associated with brain tumors can be a major cause of epilepsy refractoriness. " 05/01/2010 - "Future research on seizure management in brain tumor patients should focus on better insight into the influence of multidrug resistance proteins on anticonvulsant drug transport over the blood-brain barrier, efficacy of new anticonvulsants with no or few interactions with other drugs, synergistic combinations of anticonvulsants in order to limit toxicity and therapeutic drug monitoring of anticonvulsants in current clinical practice and in new drug studies, including the effects of concomitant administration of chemotherapeutic agents."
3.	Drug Resistant Epilepsy 12/26/2006 - "Refractory epilepsy is common in patients with structural brain lesions, and a role for multidrug-resistance proteins has been suggested. " 05/01/2005 - "Refractory epilepsy is common in patients with a structural brain lesion, and a role for multidrug resistance proteins has been suggested. " 02/01/2004 - "Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy." 01/01/2017 - "Multidrug resistance proteins (MRPs) and P-gp are over-represented in brain tissue of patients with drug-resistant epilepsy, suggesting their involvement in the clearance of antiepileptic medications. "
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/01/2009 - "Overexpression of multidrug resistance proteins (Mdrs) and enhanced antiapoptotic capability are two of the main mechanisms by which Bcr/Abl(+) chronic myeloid leukemia cells acquire drug resistance; however, it has been shown that Mdr-1 expression provides minimal protection against cell apoptosis induced by chemotherapeutic drugs. " 01/01/2009 - "imatinib, multidrug resistance proteins, chronic myeloid leukemia, PGP, MRP1, LRP."
5.	Breast Neoplasms (Breast Cancer) 09/01/2017 - "A Model for Transfer of P-Glycoproteins in MCF-7 Breast Cancer Cell Line with Multiple Transfer Rules." 01/01/2018 - "In the present study, with plasma membrane vesicle and cell-based transport studies, we showed that 25OHD3-G is a substrate of multidrug resistance proteins 2 and 3, OATP1B1, and OATP1B3, and that 25OHD3-S is probably a substrate of breast cancer resistance protein, OATP2B1, and OATP1B3. " 01/01/2020 - "The multidrug resistance proteins 1 (MDR; ABCB), the multi resistance protein (MRP2; ABCC) and the breast cancer resistance protein (BCRP, ABCG) along with the multidrug and toxin extrusion (MATE), which is an SLC transporter, carry out the substance efflux of the cell, However, uptake transporters seem to be more efficient than efflux transporters, leading to an accumulation of compounds in proximal tubular cells and, consequently, to renal damage. " 10/02/2017 - "Multidrug resistance proteins 2-4 (MRP2-MRP4) and the breast cancer resistance protein (BCRP) are efflux transporters that are expressed in these polarized cells, on either the basolateral or apical membranes. " 12/01/2016 - "The specific targets of BA in breast cancer are reported to be the estrogen receptor and various multidrug resistance proteins. "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Paclitaxel (Taxol)
4.	alvocidib (flavopiridol)
5.	Proteins (Proteins, Gene)
6.	multidrug resistance-associated protein 1
7.	Cations
8.	Peptides (Polypeptides)
9.	Anions
10.	Organic Anion Transporters

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Adjuvant Chemotherapy
3.	Therapeutics
4.	Neoadjuvant Therapy
5.	Immunomodulation