Neurotransmitter Agents (Neurotransmitter)

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.

Also Known As:

Networked: 7915 relevant articles (146 outcomes, 779 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Straub, Rainer H: 15 articles (01/2015 - 02/2005)
2.	Entschladen, Frank: 14 articles (02/2012 - 11/2002)
3.	Schuller, Hildegard M: 13 articles (12/2015 - 01/2007)
4.	Zubieta, Jon-Kar: 13 articles (03/2015 - 06/2002)
5.	Butterworth, Roger F: 13 articles (06/2013 - 08/2002)
6.	Kang, Yu-Ming: 11 articles (10/2015 - 09/2009)
7.	Zaenker, Kurt S: 11 articles (06/2008 - 11/2002)
8.	Nurse, Colin A: 10 articles (01/2015 - 12/2002)
9.	Clauw, Daniel J: 10 articles (06/2012 - 01/2004)
10.	Rogawski, Michael A: 10 articles (07/2011 - 01/2002)

Related Diseases

1.	Seizures (Seizure) 06/01/2005 - "Modulation of the AN-specific serotonergic activity may be critical in altering PTZ seizure threshold and be an important neurotransmitter system underlying the efficacy of AN DBS." 10/01/2011 - "A statistically significant improvement in SLE mitigation for the RBF interictal modulation case versus the periodic and random cases was observed, suggesting that the use of biologically-inspired neuromodulators may achieve better results for the purpose of electrical control of seizures in a clinical setting." 09/01/1990 - "These results indicated the cAMP level elevated by seizure activity was associated with monoamine neurotransmitter activity, and the seizure-induced accumulation of cAMP might take part in the process which eliminated the spread of seizure discharges and speeded up the termination of seizures." 06/01/2011 - "In rodents, KA injection resulted in recurrent seizures, behavioral changes and subsequent degeneration of selective populations of neurons in the brain, which has been widely used as a model to study the mechanisms of neurodegenerative pathways induced by excitatory neurotransmitter. " 05/01/2011 - "In this study, we measured VNS-induced changes in hippocampal neurotransmitter levels and determined their potential involvement in the anticonvulsive action of VNS, to elucidate the mechanism of action responsible for the seizure suppressing effect of VNS in an animal model for limbic seizures. "
2.	Pain (Aches) 01/15/2010 - "Non-invasive in vivo detection of cortical neurotransmitter concentrations and their changes in the presence of pain may help to better understand the biochemical principles of pain processing in the brain. " 01/01/2012 - "Meta-analyses were used to examine the efficacy of a neuromodulator on pain, depression and function as well as their safety. " 08/01/2015 - "Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission. " 03/02/2015 - "Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems. " 02/01/2015 - "This study demonstrates the presence of relationships between inflammatory factors and a specific central neurotransmitter system and circuitry, of relevance to understanding interindividual variations in regulation of responses to pain and other physical and emotional stressors. "
3.	Alzheimer Disease (Alzheimer's Disease) 05/26/2000 - "These findings extend the neurochemical profile of ENA713 and suggest that it could be useful for the treatment of Alzheimer-type dementia which is associated with multiple neurotransmitter abnormalities in the brain." 01/01/2006 - "Further studies are needed to examine the relationship between the neurotransmitter level changes and the Alzheimer's Disease (AD)." 01/01/2001 - "Based on radioligand binding studies, it has long been assumed that the neurochemical pathology of Alzheimer's disease (AD) does not involve widespread changes in post-synaptic neurotransmitter function. " 12/01/1992 - "Monoamine neurotransmitters and their metabolites in brain regions in Alzheimer's disease: a postmortem study." 01/01/1991 - "These results may suggest a relatively greater involvement of other neurotransmitter systems in younger, nonresponding Alzheimer's disease patients, and the results differ from those of a previous study."
4.	Heart Failure 01/01/2005 - "Recent studies have suggested that these neurohormones are reliably elevated in the setting of congestive heart failure and may be very helpful in its diagnosis. " 01/01/2010 - "Serial measurements of neurohormones have been shown to improve prognostication in the setting of acute heart failure (HF) or chronic HF without therapeutic intervention. " 08/01/2007 - "Serial neurohormones may serve as markers of efficacy of congestive heart failure (CHF) therapy. " 11/01/2011 - "In this study, we determined whether NF-κB activation within the PVN contributes to sympathoexcitation via interaction with neurotransmitters in the PVN during the pathogenesis of heart failure. " 07/01/2011 - "The aim of our study was to measure Mstn plasma concentrations in patients with congestive heart failure (CHF) and to evaluate their relationship with other neurohormones released in CHF. "
5.	Epilepsy (Aura) 01/01/2011 - "It is suggested that neurosteroid replacement with natural or synthetic neurosteroids may be useful in the treatment of epilepsy. " 01/01/2011 - "Synthetic analogs of neurosteroids that are devoid of hormonal side effects show promise in the treatment of diverse seizure disorders. " 01/01/2012 - "In recent years, many studies aimed to identify the pattern of gene expression of neurotransmitters involved in molecular mechanisms of epilepsy. " 01/01/1995 - "Subsequently, recognition of the importance of neurotransmitters in epilepsy prompted ligand binding studies of receptor distributions in the epileptic brain. " 02/23/1988 - "The potential use of this neurotransmitter-induced phenomenon in the study of brain plasticity in general, and of epilepsy in particular, is discussed."

Related Drugs and Biologics

1.	gamma-Aminobutyric Acid (GABA)
2.	Glutamic Acid (Glutamate)
3.	Dopamine (Intropin)
4.	Serotonin (5 Hydroxytryptamine)
5.	Acetylcholine (Acetylcholine Chloride)
6.	Antipsychotic Agents (Antipsychotics)
7.	Neurotransmitter Agents (Neurotransmitter)
8.	Norepinephrine (Noradrenaline)
9.	N-Methylaspartate (NMDA)
10.	Histamine (Histamine Dihydrochloride)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Immunotherapy
4.	Transplantation (Transplant Recipients)
5.	Ketogenic Diet