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Cutaneous Leukocytoclastic Vasculitis (Hypersensitivity Angiitis)

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Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.

Also Known As:

Hypersensitivity Angiitis; Vasculitis, Leukocytoclastic, Cutaneous; Allergic Cutaneous Angiitis; Allergic Cutaneous Vasculitis; Angiitis, Allergic Cutaneous; Cutaneous Allergic Vasculitis; Cutaneous Leukocytoclastic Angiitis; Vasculitis, Allergic Cutaneous; Allergic Cutaneous Angiitides; Allergic Cutaneous Vasculitides; Allergic Vasculitides, Cutaneous; Allergic Vasculitis, Cutaneous; Angiitides, Allergic Cutaneous; Angiitides, Cutaneous Leukocytoclastic; Angiitides, Hypersensitivity; Angiitis, Cutaneous Leukocytoclastic; Cutaneous Allergic Vasculitides; Cutaneous Angiitides, Allergic; Cutaneous Angiitis, Allergic; Cutaneous Leukocytoclastic Angiitides; Cutaneous Leukocytoclastic Vasculitides; Cutaneous Vasculitides, Allergic; Cutaneous Vasculitis, Allergic; Hypersensitivity Angiitides; Hypersensitivity Vasculitides; Leukocytoclastic Angiitides, Cutaneous; Leukocytoclastic Angiitis, Cutaneous; Leukocytoclastic Vasculitides, Cutaneous; Leukocytoclastic Vasculitis, Cutaneous; Vasculitides, Allergic Cutaneous; Vasculitides, Cutaneous Allergic; Vasculitides, Cutaneous Leukocytoclastic; Vasculitides, Hypersensitivity; Vasculitis, Cutaneous Allergic; Vasculitis, Cutaneous Leukocytoclastic; Angiitis, Hypersensitivity; Hypersensitivity Vasculitis; Vasculitis, Hypersensitivity

Networked: 163 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Systemic Vasculitis
2.	Vasculitis (Vasculitides)
3.	Purpura
4.	Polyarteritis Nodosa (Periarteritis Nodosa)
5.	Infection

Experts

1.	Garcia-Porrua, Carlos: 3 articles (10/2002 - 05/2002)
2.	Gonzalez-Gay, Miguel A: 3 articles (10/2002 - 05/2002)
3.	Kawakami, Tamihiro: 2 articles (02/2010 - 04/2008)
4.	Yee, Karen W L: 2 articles (09/2006 - 05/2006)
5.	Giles, Francis J: 2 articles (09/2006 - 05/2006)
6.	Hein, Gert: 2 articles (05/2003 - 01/2003)
7.	Stein, Günter: 2 articles (05/2003 - 01/2003)
8.	Kaufmann, Jörg: 2 articles (05/2003 - 01/2003)
9.	Amoli, Mahsa M: 2 articles (07/2002 - 05/2002)
10.	Hajeer, Ali H: 2 articles (07/2002 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cutaneous Leukocytoclastic Vasculitis:

1.	Colchicine FDA LinkGeneric 08/01/1985 - "Colchicine is effective in controlling chronic cutaneous leukocytoclastic vasculitis." 08/01/1985 - "Thus colchicine appears to be a safe and effective therapy for chronic cutaneous leukocytoclastic vasculitis." 12/01/1995 - "Colchicine in the treatment of cutaneous leukocytoclastic vasculitis. " 12/01/1995 - "To determine the efficacy of colchicine in cutaneous leukocytoclastic vasculitis, 41 patients were randomly selected to receive oral colchicine, 0.5 mg twice daily, or topical emollients. "
2.	EmollientsIBA 12/01/1995 - "To determine the efficacy of colchicine in cutaneous leukocytoclastic vasculitis, 41 patients were randomly selected to receive oral colchicine, 0.5 mg twice daily, or topical emollients. "
3.	CortisoneIBA 03/26/1999 - "By a process of exclusion, a hypersensitivity vasculitis was diagnosed and treated successfully with a high-dose cortisone regime."
4.	Erythema elevatum diutinumIBA 08/01/1989 - "An electron microscopic study was made of a patient with erythema elevatum diutinum, a rare variant of cutaneous leukocytoclastic vasculitis. " 03/01/2012 - "Erythema elevatum diutinum is a chronic and rare cutaneous leukocytoclastic vasculitis, characterized by red, purple and yellow papules, plaques and nodules, distributed symmetrically on the extensor surfaces of the limbs. " 01/01/2009 - "Hypersensitivity vasculitis with leukocytoclastic vasculitis associated with alpha-1-proteinase inhibitor." 06/01/2006 - "Cutaneous allergic vasculitis (CAV) is characterized clinically by purpuric patches with secondary ulcerations, and histologically by leukocytoclastic vasculitis with neutrophil infiltrates. " 04/01/2005 - "Erythema elevatum diutinum (EED) is a rare and chronic cutaneous leukocytoclastic vasculitis. "
5.	Immunoglobulins (Immunoglobulin)IBA 09/01/2014 - "To study the diagnostic utility and clinical associations of immunoglobulin deposition, determined by direct immunofluorescence (DIF) in cutaneous leukocytoclastic vasculitis (LCV). "
6.	Glyburide (Glibenclamide)FDA LinkGeneric 10/25/1980 - "The second case in the medical literature of hypersensitivity vasculitis induced by glybenclamide is reported, and for the first time vasculitic lesions are demonstrated in the histopathological study of liver tissue. " 10/25/1980 - "[Hypersensitivity vasculitis and granulomatous hepatitis induced by glybenclamide: a case report (author's transl)]."
7.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 05/01/2007 - "The sural nerve biopsy results showed a decrease of myelinated fibers with axonal degeneration and severe hypersensitivity vasculitis, with deposition of C1q on vessel walls. " 11/01/2009 - "It is known by a variety of names, including leukocytoclastic vasculitis, cutaneous small-vessel vasculitis (CSVV), allergic vasculitis. " 10/01/2006 - "Cutaneous leukocytoclastic vasculitis (CLV) is a small-vessel vasculitis localized to the skin. " 09/01/1999 - "Small vessel primary vasculitis (hypersensitivity vasculitis and Henoch-Schönlein purpura) was the second most common group. " 10/01/1995 - "Forty-two cases of vasculitis coincident with hairy cell leukemia (HCL) have been reported, of which 17 had panarteritis nodosa (PAN), 21 had cutaneous leukocytoclastic vasculitis (LCV), and 4 had vessel wall infiltration by hairy cells. "
8.	Immunoglobulin A (IgA)IBA 11/01/2007 - "Negative immunoglobulin A immunofluorescence staining and clinical exclusion of other disorders narrowed her diagnosis to cutaneous pulmonary hypersensitivity vasculitis." 07/01/2007 - "Histologic examination of the skin lesion confirmed cutaneous leukocytoclastic vasculitis with IgA-containing immune deposits. " 09/01/1996 - "We have demonstrated a clear association between IgA ACAs and cutaneous leukocytoclastic vasculitis. " 09/01/1996 - "ACAs restricted to the IgA isotype were present in 6 of 10 patients with cutaneous leukocytoclastic vasculitis. " 04/01/2013 - "[Paraneoplastic cutaneous leukocytoclastic vasculitis disclosing IgA multiple myeloma]."
9.	Antigen-Antibody Complex (Immune Complex)IBA 04/01/1994 - "The presence of circulating immune complexes at high titer supported the diagnosis of hypersensitivity vasculitis." 01/01/1989 - "Human hypersensitivity angiitis is a disease involving deposition of immune complexes in which patients present with palpable purpuric lesions most often on the lower extremities and sometimes associated with multiple organ involvement. " 04/01/1987 - "Cutaneous leukocytoclastic vasculitis is a reaction pattern possibly due to circulating immune complexes. " 01/01/1987 - "The histo-pathological lesions of hypersensitivity vasculitis (HV) consist in an inflammatory reaction to circulating immune complexes deposited on the vascular endothelium. " 04/01/1998 - "Immune complexes are involved in the pathogenesis of Henoch-Schönlein purpura, essential mixed cryoglobulinemia, hepatitis B-associated periarteritis nodosa and hypersensitivity vasculitis (related to infection or medications). "
10.	Streptokinase FDA Link 02/01/1992 - "Cutaneous leukocytoclastic vasculitis in relation to streptokinase." 12/01/1986 - "Hypersensitivity vasculitis associated with streptokinase." 07/01/1985 - "Hypersensitivity vasculitis associated with streptokinase." 02/01/1992 - "The case history is presented of a patient who developed a cutaneous leukocytoclastic vasculitis after he had been treated with intravenous streptokinase because of an acute myocardial infarction. " 10/01/1988 - "Hypersensitivity vasculitis complicating intravenous streptokinase therapy in acute myocardial infarction."

Therapies and Procedures

1.	Immunotherapy 04/01/1991 - "Hypersensitivity vasculitis occurring in a patient receiving immunotherapy." 06/01/1989 - "Allergy immunotherapy (hyposensitization) injections or ibuprofen were implicated as causes of hypersensitivity vasculitis in a dog suffering from probable food allergy. "
2.	Transplants (Transplant) 09/01/2006 - "One patient developed a cutaneous leukocytoclastic vasculitis requiring a skin graft. "
3.	Heart Transplantation (Grafting, Heart) 12/01/1993 - "Vasculitis may also be an iatrogenic complication of a therapeutic intervention, such as an IC-mediated hypersensitivity vasculitis after streptokinase treatment or an anti-endothelial cell antibody-associated coronary vasculitis after heart transplantation."
4.	Thrombolytic Therapy 04/01/1994 - "[Hypersensitivity vasculitis after thrombolytic therapy with APSAC (anisoylated plasminogen streptokinase activator complex). "
5.	Plasma Exchange 08/01/1998 - "She was diagnosed with acute fatty liver and hypersensitivity vasculitis and was successfully treated with whole plasma exchange, methylprednisolone pulse therapy, and transcatheter arterial embolization. "