Alphavirus Infections

01/01/2015 - "To date, no efficient and safe vaccines have been developed against any alphavirus infection. "
01/01/2013 - "While a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. "
05/01/2011 - "In spite of a continuous public health threat, to date no licensed vaccines have been developed for alphavirus infections. "
06/06/2012 - "This is the first report comparing the immunogenicity and protection against mortality for IWV vaccines and spike protein subunit and DNA vaccines against salmonid alphavirus infection in Atlantic salmon. "

06/06/2012 - "Superior protection conferred by inactivated whole virus vaccine over subunit and DNA vaccines against salmonid alphavirus infection in Atlantic salmon (Salmo salar L.)."
01/01/2001 - "The presence of the RNA replicase in the 'self-replicating' nucleic acid vaccines mimics alphavirus infection, which triggers the innate antiviral pathways of the host cells. "
06/06/2012 - "This is the first report comparing the immunogenicity and protection against mortality for IWV vaccines and spike protein subunit and DNA vaccines against salmonid alphavirus infection in Atlantic salmon. "

06/06/2012 - "This is the first report comparing the immunogenicity and protection against mortality for IWV vaccines and spike protein subunit and DNA vaccines against salmonid alphavirus infection in Atlantic salmon. "

01/01/2015 - "This study will aid future investigations in identifying host proteins as potential broad spectrum therapeutic targets for treating alphavirus infections. "
06/01/2014 - "We showed that alphavirus infection induced the formation of patches and extensions on the PM where the envelope proteins accumulate. "
04/01/2001 - "All ns proteins were associated with large cytoplasmic vacuoles (CPV), the inner surfaces of which were covered by small invaginations, or spherules, typical of alphavirus infection. "

09/01/2013 - "Together, our studies provide the first dynamic views of the alphavirus capsid protein in living cells and a system to define detailed mechanisms during alphavirus infection. "

09/01/2013 - "This investigation constitutes the first study of the midgut-specific proteome of An. gambiae in relation to alphavirus infection. "

01/01/2001 - "Role of antibodies in controlling alphavirus infection of neurons."
03/01/1984 - "Antibodies present in the colostrum and milk of immunized females play an important role in decreasing the susceptibility of sucklings to alphavirus infection."
07/01/2013 - "Under the alphavirus infection, the combined effects of the vaccine and ridostin were accompanied with increased specific humoral and cellular immune response (virus-specific antibodies and adoptive transfer of immune lymphocytes). "
01/01/2011 - "In alphavirus infection, the combined effects of the specific vaccine and ridostin were accompanied by increases in specific humoral immunity (specific antibodies) and cellular immunity (adoptive transfer of immune lymphocytes). "
01/01/1995 - "Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer."

09/11/2013 - "We validate this approach with a large-scale siRNA screen in the context of an in vivo alphavirus infection. "
01/01/2013 - "We used a genome-wide siRNA screen to identify host factors that promote or inhibit alphavirus infection in human cells. "
01/01/2012 - "We also present evidence that suggests virus-derived piRNA-like small RNAs are capable of modulating the pathogenesis of alphavirus infections in dicer-2 null mutant mosquito cell lines defective in viral siRNA production. "

09/01/2007 - "In 2005-2006 Reunion Island experienced a massive outbreak of chikungunya, a mosquito-borne alphavirus infection. "
01/01/2014 - "To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence. "
01/01/2012 - "To explore public perceptions and behaviours related to the risk of flavivirus and alphavirus infection in Southeastern regions of France following the recent colonisation of the Asian tiger mosquito, Aedes albopictus, and the identification of four autochthonous cases of dengue and chikungunya fever in these regions. "

01/01/2013 - "While there has been considerable progress in defining the structure and function of the viral proteins, relatively little is known about the host factors involved in alphavirus infection. "
05/01/1997 - "Mayaro virus (alphavirus) infection of Aedes albopictus cells results in inhibition of cell protein synthesis and viral proteins are preferably synthesized. "

10/01/2013 - "Currently, there are no licensed therapeutics for treating alphavirus infections. "

05/19/1998 - "Because Bcl-2 protein was recently found to be cleaved during apoptosis induced by Fas ligation, IL-3 withdrawal, and alphavirus infection, we assessed whether Bcl-2 protein was also cleaved during the anticancer drug (VP-16)-induced apoptotic cell death in U937 cells. "