Coronavirus Infections

Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).

Also Known As:

Networked: 104 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Pancreatitis
2.	Severe Acute Respiratory Syndrome
3.	Infection
4.	Pneumonia (Pneumonitis)
5.	Coronavirus Infections

Experts

1.	Bergmann, Cornelia C: 5 articles (03/2010 - 04/2005)
2.	Stohlman, Stephen A: 5 articles (03/2010 - 04/2005)
3.	Baric, Ralph S: 3 articles (01/2015 - 05/2014)
4.	Rottier, Peter J M: 3 articles (01/2011 - 01/2009)
5.	de Haan, Cornelis A M: 3 articles (01/2011 - 01/2009)
6.	Hinton, David R: 3 articles (03/2010 - 04/2005)
7.	Atkinson, Roscoe: 3 articles (03/2010 - 01/2008)
8.	Perlman, Stanley: 3 articles (01/2010 - 09/2005)
9.	Makino, Shinji: 3 articles (06/2009 - 02/2007)
10.	Huang, Cheng: 3 articles (06/2009 - 02/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Coronavirus Infections:

1.	Antiviral Agents (Antivirals)IBA 05/01/2015 - "However, no studies have previously reported a structural platform for the design of antiviral drugs with activities against these viruses or on the efficacy of 3CLpro inhibitors against coronavirus infection in experimental animals. " 11/01/2014 - "New viral respiratory tract infections with epidemic potential, such as severe acute respiratory syndrome, swine-origin influenza A H1N1, and Middle East respiratory syndrome coronavirus infection, require development of new antiviral agents. "
2.	Neutralizing AntibodiesIBA 01/01/1998 - "Protection against coronavirus infections can be provided by the oral administration of virus neutralizing antibodies. " 12/01/2014 - "Broadly neutralizing antibodies (nAbs) that prevent infection of related viruses represent an important immunostrategy for combating coronavirus infections; however, for this strategy to succeed, it is essential to uncover nAb-mediated escape pathways and to pioneer strategies that prevent escape. " 01/01/2009 - "Serology results, from a neutralizing antibody assay, were considered positive if the sera inhibited the development of a severe acute respiratory syndrome-associated coronavirus-specific cytopathic effect at a dilution of > or =1:8. Neutralizing antibody to severe acute respiratory syndrome-associated coronavirus was demonstrated in 8 of 25 children admitted with suspect severe acute respiratory syndrome-associated coronavirus infection. " 01/01/2007 - "Inhibition of severe acute respiratory syndrome-associated coronavirus infection by equine neutralizing antibody in golden Syrian hamsters." 01/01/2005 - "Protection of mammalian cells from severe acute respiratory syndrome coronavirus infection by equine neutralizing antibody."
3.	InterferonsIBA 11/01/1983 - "Intranasal interferon as protection against experimental respiratory coronavirus infection in volunteers." 01/01/2010 - "Autocrine interferon priming in macrophages but not dendritic cells results in enhanced cytokine and chemokine production after coronavirus infection." 01/01/1983 - "Interferon induction in rotavirus and coronavirus infections: a review of recent results."
4.	Proteasome Endopeptidase Complex (Proteasome)IBA 12/01/2010 - "The results further suggest that targeting the proteasome may be an effective new treatment for severe coronavirus infections." 08/01/2010 - "The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle."
5.	FOY 305 (camostat)IBA 04/01/2015 - "Camostat has been clinically used to treat chronic pancreatitis, and thus represents an exciting potential therapeutic for respiratory coronavirus infections. "
6.	Proteins (Proteins, Gene)IBA 10/01/1995 - "The aim of this study was to evaluate the use of recombinant, bacterial expressed proteins in the serodiagnosis of coronavirus infections. " 01/01/2015 - "Investigation of the functional roles of host cell proteins involved in coronavirus infection using highly specific and scalable RNA interference (RNAi) approach." 09/01/2014 - "In contrast, the role of IFITM proteins in coronavirus infection is less well defined. " 01/01/2011 - "Indeed, depletion of a small subset of the affected proteins by using small interfering RNAs identified several host factors involved in coronavirus infection. " 04/01/2008 - "The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has led to a renewed interest in studying the role of accessory proteins in regulating coronavirus infections in the natural host. "
7.	Nucleocapsid ProteinsIBA 02/01/2013 - "Previous studies have reported that a prokaryotic-expressed recombinant nucleocapsid protein (NP) is a suitable reagent for the epidemiological screening of coronavirus infection. " 11/01/2015 - "Antibody against nucleocapsid protein predicts susceptibility to human coronavirus infection." 02/01/2014 - "Use of recombinant nucleocapsid proteins for serological diagnosis offeline coronavirus infection by three immunochromatographic tests." 02/01/2013 - "Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: implications for the diagnosis of coronavirus infection." 07/01/2005 - "Evaluation of inapparent nosocomial severe acute respiratory syndrome coronavirus infection in Vietnam by use of highly specific recombinant truncated nucleocapsid protein-based enzyme-linked immunosorbent assay."
8.	Interferon Type IIBA 02/01/2007 - "This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. " 01/01/2008 - "Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells." 02/01/2007 - "Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon." 05/01/2012 - "Protective role of Toll-like Receptor 3-induced type I interferon in murine coronavirus infection of macrophages."
9.	Staphylococcal Protein A (A, Protein)IBA 04/01/2012 - "This study reveals that pRb and its interaction with Nsp15 can affect coronavirus infection and adds coronaviruses to a small but growing family of RNA viruses that encode a protein to interact with pRb." 10/14/2014 - "The MERS-CoV spike (S) protein, a characteristic structural component of the viral envelope, is considered as a key target of vaccines against coronavirus infection. "
10.	Retinaldehyde (Retinal)IBA 05/01/1991 - "Moreover, these studies show that long-lasting retinal disorders ranging in intensity from mild to severe can occur after coronavirus infection."

Therapies and Procedures

1.	Oral Administration 01/01/1998 - "Protection against coronavirus infections can be provided by the oral administration of virus neutralizing antibodies. "
2.	Therapeutics 08/01/2014 - "Registered therapeutics for the treatment of coronavirus infections are not available. " 01/01/2013 - "As a definitive treatment regimen has never been thoroughly evaluated for coronavirus infections, there is an urgent need to rapidly identify potential therapeutics to address future cases of nCoV. "
3.	Dental Care 12/20/2003 - "Maintaining dental education and specialist dental care during an outbreak of a new coronavirus infection. " 11/22/2003 - "Maintaining dental education and specialist dental care during an outbreak of a new coronavirus infection. "
4.	Transplants (Transplant) 05/01/2003 - "Little is known about the impact of human rhinovirus (HRV) and coronavirus infections in hematopoietic stem cell transplant (HSCT) recipients. "
5.	Transplantation (Transplant Recipients) 07/01/2015 - "The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients."