Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)

Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.

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Networked: 852 relevant articles (3 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Safe, Stephen: 15 articles (05/2015 - 06/2002)
2.	Lawrence, B Paige: 14 articles (12/2015 - 04/2004)
3.	Perdew, Gary H: 11 articles (06/2015 - 05/2008)
4.	Fujii-Kuriyama, Yoshiaki: 9 articles (08/2015 - 11/2002)
5.	Matsumura, Fumio: 9 articles (05/2015 - 01/2004)
6.	El-Kadi, Ayman O S: 9 articles (02/2012 - 09/2004)
7.	Gonzalez, Frank J: 9 articles (01/2011 - 01/2004)
8.	Safe, S: 9 articles (05/2001 - 04/2000)
9.	Vorderstrasse, Beth A: 8 articles (08/2015 - 04/2004)
10.	Machala, Miroslav: 8 articles (07/2015 - 04/2006)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2002 - "This study shows that ICZ may possess tumor promoter activity down-regulating GJIC by mechanisms, which seem to include activation of the Ah receptor and/or Cyp1 activity. " 07/01/1988 - "In the studies reported here, we show that the in vivo generation of cytotoxic T lymphocytes (CTL) in response to allogeneic tumor challenge is sensitive to suppression by 3,4,5,3',4',5'-hexachlorobiphenyl[(345)2-HxCB], a poorly metabolized, toxic, Ah receptor-binding PCB isomer. " 10/01/2015 - "The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor." 01/01/2015 - "The expression of these CYPs is regulated by aryl hydrocarbon receptors (AHR), the cellular target of PAH, and an important player in various diseases including cancer. " 01/01/2015 - "The aryl hydrocarbon receptor (AhR) is a heterodimeric transcriptional regulator with pleiotropic functions in xenobiotic metabolism and detoxification, vascular development and cancer. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "Previous studies showed anti-metastatic roles of agonist-activated aryl hydrocarbon receptor (Ahr) in various breast cancer cell lines. " 02/01/2010 - "In the current study, we report that ligand activation of the aryl-hydrocarbon receptor (AhR) inhibits multiple aspects of the metastatic process in a panel of breast cancer cell lines that represent the major breast cancer subtypes. " 05/18/2015 - "Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells." 05/01/2015 - "The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells." 02/01/2015 - "A novel compound, NK150460, exhibits selective antitumor activity against breast cancer cell lines through activation of aryl hydrocarbon receptor."
3.	Inflammation 12/15/2015 - "Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells." 08/01/2015 - "Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade." 07/01/2015 - "Aryl hydrocarbon receptor (AHR) is believed to control the chronic inflammation in the gut. " 06/02/2015 - "Activation of aryl hydrocarbon receptor (AhR) and Nrf2-mediated oxidative stress response were found to be the most prominent effects, while the p53-mediated DNA damage response and NF-κB-mediated response to inflammation were not significantly affected. " 01/01/2014 - "The aryl hydrocarbon receptor (AhR) has gradually emerged as a regulator of inflammation in the lung and other tissues. "
4.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2013 - "The aryl hydrocarbon receptor (AhR) has been attributed with anti-inflammatory effects in the development of pathological immune responses leading to experimental autoimmune encephalomyelitis (EAE) via the induction of regulatory T cells. " 11/30/2010 - "An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis." 12/01/2007 - "Resveratrol (trans-3,5,4'-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor." 10/01/2013 - "The activation of aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alleviates inflammation in experimental autoimmune encephalomyelitis (EAE), the best available model of MS. Therefore, we predicted that TCDD could attenuate EAE by inducing miRNA(s) targeting inflammatory mediators. "
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/1990 - "In this study we compare the subunit composition of two forms of the dioxin receptor, sedimenting at approximately 9S and approximately 6S respectively, which are present in nuclear extract from wild-type Hepa 1c1c7 mouse hepatoma cells following treatment in vivo with dioxin. " 01/01/1988 - "In this study we used a rat hepatoma cell line, H4IIE, to investigate the effect of such substances on an enzyme system, aryl hydrocarbon hydroxylase (AHH), which is regulated via the TCDD receptor. " 03/04/2015 - "We examined the expression kinetics of some of the aryl hydrocarbon receptor (AhR)-regulated genes in LA1 variant cells compared to wild type (WT) Hepa-1 mouse hepatoma cell lines, and we investigated the stability of AhR protein as a key step in the function of this receptor. " 12/01/2013 - "The interleukin-6-type cytokine oncostatin M induces aryl hydrocarbon receptor expression in a STAT3-dependent manner in human HepG2 hepatoma cells." 06/01/2013 - "The aryl-hydrocarbon-receptor (AhR) reporter system was utilized to transport a dioxin-responsive-element (DRE) via an adenovirus vector into rat hepatoma (H4IIE) cells before each experiment; these DRE-H4IIE cells were utilized in the Ad-DR bioassay. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Tetrachlorodibenzodioxin (TCDD)
3.	resveratrol
4.	Ethanol (Ethyl Alcohol)
5.	Arachidonic Acid (Vitamin F)
6.	Cytochrome P-450 CYP1A1 (CYP1A1)
7.	Cytochrome P-450 Enzyme System (Cytochrome P450)
8.	Cytochromes
9.	Transcription Factors (Transcription Factor)
10.	Enzymes

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Aftercare (After-Treatment)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Chemoprevention
5.	Drug Therapy (Chemotherapy)