Calcifying Odontogenic Cyst

A mixed radiolucent-radiopaque lesion of the jaws with features of both a cyst and a solid neoplasm. It is characterized microscopically by an epithelial lining showing a palisaded layer of columnar basal cells, presence of ghost cell keratinization, dentinoid, and calcification. (Stedman, 25th ed)

Also Known As:

Networked: 59 relevant articles (0 outcomes, 11 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Odontogenic Cysts (Keratocyst)
2.	Odontogenic Tumors (Dental Tissue Neoplasm)
3.	Ameloblastoma
4.	Cysts
5.	Odontoma

Experts

1.	Gomes, Carolina Cavalieri: 3 articles (03/2019 - 11/2007)
2.	Gomez, Ricardo Santiago: 3 articles (03/2019 - 11/2007)
3.	Koutlas, Ioannis G: 2 articles (12/2018 - 03/2012)
4.	Souza, Ana Cristina Rodrigues Antunes: 2 articles (01/2018 - 11/2007)
5.	Souza, Leandro Napier: 2 articles (01/2018 - 11/2007)
6.	Salehinejad, Jahanshah: 2 articles (05/2011 - 12/2010)
7.	Nikai, H: 2 articles (08/2000 - 04/2000)
8.	Takata, T: 2 articles (08/2000 - 04/2000)
9.	Uchida, T: 2 articles (08/2000 - 04/2000)
10.	Wang, T: 2 articles (08/2000 - 04/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Calcifying Odontogenic Cyst:

1.	Keratins (Keratin)IBA 07/01/1997 - "Calcifying odontogenic cyst: a clinicopathologic study of 57 cases with immunohistochemical evaluation for cytokeratin." 03/01/2005 - "Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst." 11/01/1983 - "The keratinizing and calcifying odontogenic cyst (KCOC), a lesion that features proliferating ameloblastic epithelium, ghost keratin, calcification, and cyst formation, may more precisely mimic the craniopharyngioma. " 03/01/2003 - "Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. " 12/01/2020 - "The aim of our study was to ascertain the true nature of ghost cells (GCs) by immunolocalization of cytokeratin (CK) 6, CK19, and amelogenin in calcifying odontogenic cysts (COCs) and dentinogenic ghost cell tumors (DGCTs) in an attempt to determine the nature of this unique cell. "
2.	AmelogeninIBA 09/01/2001 - "In odontogenic tumors, positive reactions for amelogenin were localized in limited areas in adenomatoid odontogenic tumor, calcifying odontogenic cyst, primary intraosseous carcinoma and odontoma. " 12/01/2020 - "The aim of our study was to ascertain the true nature of ghost cells (GCs) by immunolocalization of cytokeratin (CK) 6, CK19, and amelogenin in calcifying odontogenic cysts (COCs) and dentinogenic ghost cell tumors (DGCTs) in an attempt to determine the nature of this unique cell. " 03/01/1992 - "Amelogenin and enamelin were demonstrated in small mineralized foci and in the tumor cells surrounding them in adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), and calcifying odontogenic cyst (COC). " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. " 01/01/2021 - "The aim of this study was to evaluate if the expression of amelogenin, cytokeratin AE1/AE3 (CKAE1/AE3) and cytokeratin 14 (CK14) in cysts and odontogenic tumors with calcified matrices such as calcifying odontogenic cyst (COC), compound (CdO) and complex (CxO) odontomas, adenomatoid odontogenic tumor (AOT) and calcifying epithelial odontogenic tumor (CEOT) as an aggressiveness indicator. "
3.	AntibodiesIBA 12/01/2018 - "Fourteen ameloblastomas, 7 adenomatoid odontogenic tumors, 6 calcifying epithelial odontogenic tumors, 1 squamous odontogenic tumor, 4 primary intraosseous odontogenic carcinomas, 5 calcifying odontogenic cysts, 4 glandular odontogenic cysts, 3 odontogenic keratocysts, 3 dentigerous cysts, and 1 each radicular and orthokeratinized cysts were stained for p63 (4A4) and p40 (BC28) antibodies. " 05/01/2003 - "The purpose of this study was to investigate a case of calcifying odontogenic cyst (COC) in which numerous calcifications were observed not only in the lining epithelium, but also in the cyst wall, using cytokeratins 13 (CK13), 19 (CK19), and core binding factor a-1 (cbfa-1) as primary antibodies. " 10/01/2002 - "Specimens of five tooth germs, 34 ameloblastomas, three calcifying epithelial odontogenic tumors (CEOTs), two clear cell odontogenic tumors (CCOTs), five adenomatoid odontogenic tumors (AOTs), six calcifying odontogenic cysts (COCs) and six malignant ameloblastomas were examined immunohistochemically with the use of antibodies against HGF, TGF-beta and their receptors. " 03/01/2005 - "To examine the properties of shadow and ghost cells, 3 kinds of antibodies were raised against human hair proteins and their immunoreactivity was examined in tumors expressing those cells: pilomatrixoma, 14 cases; craniopharyngioma, 17 cases; and calcifying odontogenic cyst (COC), 14 cases. " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. "
4.	Proteins (Proteins, Gene)FDA Link 04/01/2000 - "Ghost cells in calcifying odontogenic cyst express enamel-related proteins." 10/16/2020 - "This work showcases 24 ameloblastoma cases, 10 calcifying odontogenic cysts, and 9 dental follicles, used to investigate the expression of these proteins by immunohistochemistry. " 09/01/2005 - "A total of 123 cases of odontogenic cysts, distributed as follows: 30 follicular (FC), 35 radicular (RC), 53 keratocysts, 1 glandular odontogenic and 4 calcifying odontogenic cysts, were analysed by immunohistochemistry for expression of p63, a component of p53 protein family. " 04/01/2000 - "The results indicate that the ghost cells in calcifying odontogenic cysts, as opposed to ghost cells in dermal calcifying epitheliomas, contain enamel-related proteins in their cytoplasm accumulated during the process of pathological transformation." 04/01/2000 - "The cytoplasm of ghost cells in calcifying odontogenic cysts demonstrated distinct immunolocalization of the enamel-related proteins, while similar in the calcifying epitheliomas of the skin showed a negative reaction. "
5.	Matrix Metalloproteinase 20IBA 08/01/2000 - "Furthermore, enamelysin was also detected in globular amyloid masses and calcified foci in calcifying epithelial odontogenic tumors, hyaline droplets, small and large mineralized areas in adenomatoid odontogenic tumors, and a portion of ghost cells in calcifying odontogenic cysts. " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. "
6.	LectinsIBA 01/01/1985 - "[Histochemical studies on lectin-binding of the ghost cells in calcifying odontogenic cysts and odontomas]." 01/01/2000 - "Dentinogenic ghost cell tumor accompanied with calcifying odontogenic cyst (COC) was described in terms of its clinical, histological, immunohistochemical, lectin binding and biophysical properties. "
7.	tuftelin (enamelin)IBA 03/01/1992 - "Amelogenin and enamelin were demonstrated in small mineralized foci and in the tumor cells surrounding them in adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), and calcifying odontogenic cyst (COC). " 04/01/2000 - "In the present study, we examined the immunoreactivity of ghost cells in calcifying odontogenic cysts and dermal calcifying epitheliomas, with antibodies against amelogenin, enamelin, sheath protein (sheathlin) and enamelysin, in an attempt to clarify the nature of this unique cell. "
8.	Claudin-1IBA 05/01/2022 - " This study aimed to analyze claudin-1, -4, and -7 expression in different types of odontogenic cysts (odontogenic keratocysts [OKCs], dentigerous cysts [DCs], calcifying odontogenic cysts [COCs], and radicular cysts [RCs]) as well as its association with OKC recurrence. "
9.	MART-1 AntigenIBA 03/01/2012 - "Melan-A/Mart-1- or HMB-45-positive melanocytes are not present in calcifying cystic odontogenic tumors (calcifying odontogenic cysts): a study in 13 Caucasian patients."
10.	Versicans (Versican)IBA 09/01/2002 - "The present study investigated the localization of versican in odontogenic tumors by immunohistochemistry, using paraffin-embedded sections obtained from 27 patients with odontogenic tumors (17 ameloblastomas, 1 adenomatoid odontogenic tumor, 4 odontogenic keratocysts, 1 calcifying odontogenic cyst, 2 ameloblastic fibromas, and 2 malignant ameloblastomas). "

Therapies and Procedures

1.	Oral Pathology 07/01/1997 - "A clinicopathologic study of all cases accessioned as calcifying odontogenic cyst (COC) from 1971 to 1996 from the files of the Oral Pathology Laboratory at Temple University School of Medicine was undertaken. " 05/01/2011 - "To reevaluate all cases previously diagnosed as calcifying odontogenic cyst (COC) from the archives of the Department of Oral Pathology at Mashhad Faculty of Dentistry from 1978 to 2008. " 01/01/2005 - "Oral pathology quiz # 47: case number 4. Calcifying odontogenic cyst." 01/01/2020 - "With IRB approval, cases from the following entities were identified from archives of the UF Oral Pathology Biopsy Service (2005-2015): benign incidental odontogenic rest, dentigerous cyst, lateral periodontal cyst, calcifying odontogenic cyst, glandular odontogenic cyst, odontogenic keratocyst, orthokeratinized odontogenic cyst, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, and ameloblastoma. " 06/01/2018 - "To identify the prevalence and clinicopathological profile of calcifying odontogenic cysts (COC) stored at an oral pathology service, and to analyze the immunoexpression of cyclooxygenase 2 (COX-2) and cyclin D1 (CD1) in these cysts. "
2.	Decompression 03/01/2021 - "In this paper, we employ a patient with an enormous calcifying odontogenic cyst to review both the pathology and active decompression and distraction sugosteogenesis, a novel technique employed to treat odontogenic entities. " 03/01/2021 - "Active decompression and distraction sugosteogenesis for the treatment of calcifying odontogenic cyst." 01/01/2018 - "Tube Decompression for Staged Treatment of a Calcifying Odontogenic Cyst." 01/01/2018 - "Regarding "Tube Decompression for Staged Treatment of a Calcifying Odontogenic Cyst-A Case Report"." 09/01/2017 - "Tube Decompression for Staged Treatment of a Calcifying Odontogenic Cyst-A Case Report."
3.	Lasers (Laser) 05/01/2011 - "Calcifying odontogenic cysts associated with odontomas: confocal laser scanning microscopy analysis of 13 cases."
4.	Curettage 09/01/1996 - "18 Patients with calcifying odontogenic cyst underwent surgery in our Department from 1977 to 1993 were reported.8 male and 10 female aged from 11 to 52 with medium or 33 years were included.16 cases were pathologically confirmed as primary intraosseous cyst(central),and 2 as extraosseous cyst(peripheral).There was no recurrence after the local excision for preripheral calcifying odontogenic cyst and local curettage for central one.There"
5.	Conservative Treatment 11/01/2007 - "Conservative treatment of calcifying odontogenic cyst: report of 3 cases."